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Articles 1 - 9 of 9
Full-Text Articles in Developmental Neuroscience
Empathy-Based Conservation: An Interdisciplinary Approach To Conservation Policy And Decision-Making, Kaitlyn Delashmutt
Empathy-Based Conservation: An Interdisciplinary Approach To Conservation Policy And Decision-Making, Kaitlyn Delashmutt
Department of Environmental Studies: Undergraduate Student Theses
In the late 20th century, neuroscientists in Italy discovered a neuron in the brain capable of mentally mimicking the emotions derived from the actions of others (Rizzolatti and Craighero, 2004). It is the process that makes your elbow ache when someone else knocks their elbow on the counter or the uncontrollable smile that creeps up when someone smiles at you. No questions asked, people intuitively sense what others are feeling. The old school of thought was that humans deduced through logic and reason the actions of others and interpreted the emotions through a rational process (Carew et al, 2008). …
In Search Of The Neurobiological Substrates For Social Playfulness In Mammalian Brains, Stephen M. Siviy, Jaak Panksepp
In Search Of The Neurobiological Substrates For Social Playfulness In Mammalian Brains, Stephen M. Siviy, Jaak Panksepp
Psychology Faculty Publications
Play behavior is a fundamental and intrinsic neurobehavioral process in the mammalian brain. Using rough-and-tumble play in the juvenile rat as a model system to study mammalian playfulness, some of the relevant neurobiological substrates for this behavior have been identified, and in this review this progress. A primary-process executive circuit for play in the rat that includes thalamic intralaminar nuclei, frontal cortex and striatum can be gleaned from these data. Other neural areas that may interact with this putative circuit include amygdala, ventral hypothalamus, periaqueductal gray (PAG), and deep tectum, as well as ascending dopamine systems which participate in all …
Serotonin, Motivation, And Playfulness In The Juvenile Rat, Stephen M. Siviy, Loren M. Deron, Chelsea R. Kasten
Serotonin, Motivation, And Playfulness In The Juvenile Rat, Stephen M. Siviy, Loren M. Deron, Chelsea R. Kasten
Psychology Faculty Publications
The effects of the selective 5HT1A agonist 8-OH-DPAT were assessed on the play behavior of juvenile rats. When both rats of the test pair were comparably motivated to play, the only significant effect of 8-OH-DPAT was for play to be reduced at higher doses. When there was a baseline asymmetry in playful solicitation due to a differential motivation to play and only one rat of the pair was treated, low doses of 8-OH-DPAT resulted in a collapse of asymmetry in playful solicitations. It did not matter whether the rat that was treated initially accounted for more nape contacts or fewer …
Bone Morphogenetic Protein Inhibition Promotes Neurological Recovery After Intraventricular Hemorrhage, Krishna Dummula, Govindaiah Vinukonda, Philip Chu, Yiping Xing, Furong Hu, Sabrina Mailk, Anna Csiszar, Caroline Chua, Peter Mouton, Robert J. Kayton, Joshua C. Brumberg, Rashmi Bansal, Praveen Ballabh
Bone Morphogenetic Protein Inhibition Promotes Neurological Recovery After Intraventricular Hemorrhage, Krishna Dummula, Govindaiah Vinukonda, Philip Chu, Yiping Xing, Furong Hu, Sabrina Mailk, Anna Csiszar, Caroline Chua, Peter Mouton, Robert J. Kayton, Joshua C. Brumberg, Rashmi Bansal, Praveen Ballabh
Publications and Research
Intraventricular hemorrhage (IVH) results in neural cell death and white matter injury in premature infants. No therapeutic strategy is currently available against this disorder. Bone morphogenetic protein (BMP) signaling suppresses oligodendrocyte development through basic-helix-loop-helix (bHLH) transcription factors and promotes astrocytosis. Therefore, we hypothesized that IVH in premature newborns initiates degeneration and maturation arrest of oligodendrocyte lineage and that BMP inhibition alleviates hypomyelination, gliosis, and motor impairment in the survivors of IVH. To test the hypotheses, a rabbit model of IVH was used in which premature rabbit pups (E29) are treated with intraperitoneal glycerol at 2 hours of age to induce …
Dysfunctional Play And Dopamine Physiology In The Fischer 344 Rat, Stephen M. Siviy, Cynthia A. Crawford, Garnik Akopian, John P. Walsh
Dysfunctional Play And Dopamine Physiology In The Fischer 344 Rat, Stephen M. Siviy, Cynthia A. Crawford, Garnik Akopian, John P. Walsh
Psychology Faculty Publications
Juvenile Fischer 344 rats are known to be less playful than other inbred strains, although the neurobiological substrate(s) responsible for this phenotype is uncertain. In the present study, Fischer 344 rats were compared to the commonly used outbred Sprague-Dawley strain on several behavioral and physiological parameters in order to ascertain whether the lack of play may be related to compromised activity of brain dopamine (DA) systems. As expected, Fischer 344 rats were far less playful than Sprague-Dawley rats, with Fischer 344 rats less likely to initiate playful contacts with a playful partner and less likely to respond playfully to these …
Investigation Of Mirnas Expression In A Citron-Kinase Mutant Model Of Microcephaly, Shan Parikh
Investigation Of Mirnas Expression In A Citron-Kinase Mutant Model Of Microcephaly, Shan Parikh
Master's Theses
Mutation of Citron-Kinase (Cit-K) in rodents causes substantial reductions in the number of neurons generated in the CNS and results in a primary microcephaly-like phenotype. Evidence from drosophila genetics has further established a genetic link between Cit-K and a protein Argonaut 1 (AGO1), which is required for proper functioning of the miRNA machinery (2). Experiments characterizing the role of miRNAs in the developing cortex demonstrate the requirement of miRNAs for differentiation of neural progenitor cells starting at embryonic day 12.5 (3). Together, this evidence links the role of miRNAs to neurogenesis and thus this relationship warrants further investigation. Here miRNA …
Family Art Therapy: A Case Report Of A Family With A Child With Autism, E. Lange Eve
Family Art Therapy: A Case Report Of A Family With A Child With Autism, E. Lange Eve
EVMS School of Health Professions Theses & Dissertations
Children diagnosed with an Autism Spectrum Disorder can experience a wide range of difficulties due to social and communication impairments. These challenges also affect the child’s family and can cause stress and disturbances within the family system. This case report describes an eight-week art therapy experience with a family who has a child with autism. A Projective Imagery Family Evaluation (PIFE) was conducted, followed by a discussion session with the family and then six one-hour art therapy sessions. The sessions occurred once a week and were implemented to address the specific concerns demonstrated by the family. Participants included a mother, …
Nico-Teen: Neural Substrates That Mediate Adolescent Tobacco Abuse., Laura O'Dell
Nico-Teen: Neural Substrates That Mediate Adolescent Tobacco Abuse., Laura O'Dell
Selected Works Temporary Series
No abstract provided.
Nico-Teen: Neural Substrates That Mediate Adolescent Tobacco Abuse., Laura O'Dell
Nico-Teen: Neural Substrates That Mediate Adolescent Tobacco Abuse., Laura O'Dell
Departmental Papers (Psych)
No abstract provided.