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Articles 1 - 4 of 4
Full-Text Articles in Developmental Neuroscience
D1 Dopamine Receptor Regulation Of Microtubule-Associated Protein-2 Phosphorylation In Developing Cerebral Cortical Neurons, Z.-M. Song, Ashiwel S. Undieh, Y.-Y. Fang, L. Zhang, S. Dracheva, S.C. Sealfon, M.S. Lidow
D1 Dopamine Receptor Regulation Of Microtubule-Associated Protein-2 Phosphorylation In Developing Cerebral Cortical Neurons, Z.-M. Song, Ashiwel S. Undieh, Y.-Y. Fang, L. Zhang, S. Dracheva, S.C. Sealfon, M.S. Lidow
Publications and Research
This study addresses the hypothesis that the previously described capacity of D1 dopamine receptors (D1Rs) to regulate dendritic growth in developing cortical neurons may involve alterations in the phosphorylation state of microtubuleassociated protein-2 (MAP2). The changes in phosphorylation of this protein are known to affect its ability to stabilize the dendritic cytoskeleton. The study involved two systems: primary cultures of mouse cortical neurons grown in the presence of the D1R agonists, SKF82958 or A77636, and the cortex of neonatal transgenic mice overexpressing the D1A subtype of D1R. In both models, a decrease in dendritic extension corresponded with an elevation in …
Enhanced Locomotor, Reinforcing, And Neurochemical Effects Of Cocaine In Serotonin 5-Hydroxytryptamine 2c Receptor Mutant Mice, Laura O'Dell
Enhanced Locomotor, Reinforcing, And Neurochemical Effects Of Cocaine In Serotonin 5-Hydroxytryptamine 2c Receptor Mutant Mice, Laura O'Dell
Selected Works Temporary Series
No abstract provided.
Enhanced Locomotor, Reinforcing, And Neurochemical Effects Of Cocaine In Serotonin 5-Hydroxytryptamine 2c Receptor Mutant Mice, Laura O'Dell
Enhanced Locomotor, Reinforcing, And Neurochemical Effects Of Cocaine In Serotonin 5-Hydroxytryptamine 2c Receptor Mutant Mice, Laura O'Dell
Departmental Papers (Psych)
No abstract provided.
Domain-Specific Olivocerebellar Projection Regulated By The Epha-Ephrin-A Interaction, Kazuhiko Nishida, John Flanagan, Masaru Nakamoto
Domain-Specific Olivocerebellar Projection Regulated By The Epha-Ephrin-A Interaction, Kazuhiko Nishida, John Flanagan, Masaru Nakamoto
Biology Faculty Publications
Neural maps in the vertebrate central nervous system often show discontinuously segregated, domain-to-domain patterns. However, the molecular mechanism that establishes such maps is not well understood. Here we show that in the chicken olivocerebellar system, EphA receptors and ephrin-As are expressed with distinct levels and combinations in mapping domains. When ephrin-A2 is retrovirally overexpressed in the cerebellum, the olivocerebellar map is disrupted, excluding axons with high receptor activity from ectopic expression domains. Conversely, overexpression of a truncated EphA3 receptor in the cerebellum reduces endogenous ligand activity to undetectable levels and causes aberrant mapping, with high receptor axons invading high ligand …