Developmental Neuroscience Commons^™

Neural Efficiency Hypothesis In Motor Actions; Spectral Power Of Balancing Ballet Dancers, Carter G. Disantis

Senior Theses

Reduced activity observed during functional imaging of motor experts led to the Neural Efficiency Hypothesis (NEH) in motor skills, which posits that expert performers use fewer neural resources during motor execution than novices, reflecting greater neural efficiency.

This pilot study compared EEG recordings from five novices and four expert ballet dancers during standing and one-leg balance. Whole-brain theta (4–8 Hz) and alpha (8–12 Hz) power were quantified, and topographic maps were generated. In addition to testing the primary hypotheses, the experimental design was evaluated as a practical and scalable approach for investigating the NEH in motor skills. Novices showed significantly …

Early Motor And Language Development In Infants At Elevated Likelihood For Autism, Natalie C. Deal

Senior Theses

During the early stages of infant development, various emerging skills set the foundation for more complex abilities. One such connection is the development of motor skills, which play a crucial role in influencing language outcomes later in the infants' first year. Although these developmental cascades are well understood in typically-developing populations, less is known about the cascade in infants at elevated likelihood for autism spectrum disorder (ASD). Many infants who are later diagnosed with ASD have motor delays or language delays, suggesting that the cascade from motor to language may not be typical in this population. Additionally, little is known …

Analysis Of Genes Responsible For Neuronal Morphological Changes In Down Syndrome Hipsc-Derived Neurons, Juhi Patel

Senior Theses

Down syndrome (DS) is a complex neurodevelopmental disorder caused by the trisomy of chromosome 21. DS is the largest genetic cause of intellectual disability, which occurs in varying severity among affected individuals. It is associated with a variety of developmental and cognitive defects, including reduced brain size, impaired synaptic function, and altered neuronal morphology. A number of genes have been identified to play critical roles in the development and maintenance of neuronal morphology, and alterations in the expression of some of these genes are implicated in the morphological changes observed in DS. Knocking out or altering their expression leads to …

The Effect Of Physical Activity And S-Equol On Neurogenesis In The Hiv-1 Transgenic Rat, Jeremy M. Lapointe

Senior Theses

The aim of this thesis is to investigate the effect of physical activity and the administration of s-equol on rates of neurogenesis in HIV-1 transgenic rats. HIV-1 is a neurodegenerative disease that leads to the wide range of cognitive impairment described as HAND. Neurogenesis is a newly discovered process that involves the birth of new neurons during our adult life within the dentate gyrus of the hippocampus. Therefore, inducing neurogenesis may be a proper therapeutic that can mitigate some of the cognitive destruction seen as a result of HIV-1 infection. Physical activity has shown to increase the rate of neurogenesis …

The Role Of Ash1l During Human Neurodevelopment, Anna Bagnell

Senior Theses

Autism spectrum disorders (ASD) are associated with defects in neuronal connectivity and are highly heritable. A significant proportion of ASD cases are of complex genetic etiology; complexity which might reflect the impact of gene-environment interactions. However, there is a gap in our understanding of the mechanisms that underlie the gene-environment interaction in autism complex etiology. Genome wide association studies in large ASD cohorts identified high risk variants associated with autism in genes that regulate histone modifications and remodel chromatin. These findings highlight the relevance of chromatin regulatory mechanisms in the pathology of ASD. Changes in Histone H3 methylation have been …