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Articles 1 - 5 of 5
Full-Text Articles in Developmental Neuroscience
Gabaergic Interneurons And Prenatal Ethanol Exposure: From Development To Aging, Adelaide R. Tousley
Gabaergic Interneurons And Prenatal Ethanol Exposure: From Development To Aging, Adelaide R. Tousley
Dartmouth College Ph.D Dissertations
Fetal Alcohol Spectrum Disorders are the most common non-genetic cause of neurodevelopmental disability worldwide. Individuals with Fetal Alcohol Spectrum Disorder experience clinical symptoms including differences in physical, cognitive and behavioral development beginning in early childhood, but continue to face challenges into adulthood. There is a critical need to examine the effects of prenatal ethanol exposure across early development, and to establish how the developmental effects of prenatal ethanol exposure may or may not progress in aging individuals. To contribute to these two areas, I asked how a binge-type prenatal ethanol exposure might affect: (1) early postnatal development of striatal neurons …
Acth Prevents Deficits In Fear Extinction Associated With Early Life Seizures, Andrew T. Massey, David K. Lerner, Gregory L. Holmes, Rod C. Scott, Amanda Hernan
Acth Prevents Deficits In Fear Extinction Associated With Early Life Seizures, Andrew T. Massey, David K. Lerner, Gregory L. Holmes, Rod C. Scott, Amanda Hernan
Dartmouth Scholarship
Objective: Early life seizures (ELS) are often associated with cognitive and psychiatric comorbidities that are detrimental to quality of life. In a rat model of ELS, we explored long-term cognitive outcomes in adult rats. Using ACTH, an endogeneous HPA-axis hormone given to children with severe epilepsy, we sought to prevent cognitive deficits. Through comparisons with dexamethasone, we sought to dissociate the corticosteroid effects of ACTH from other potential mechanisms of action.
Results: Although rats with a history of ELS were able to acquire a conditioned fear learning paradigm and controls, these rats had significant deficits in their ability to extinguish …
Prenatal Predictors Of Infant Self-Regulation: The Contributions Of Placental Dna Methylation Of Nr3c1 And Neuroendocrine Activity, Elisabeth Conradt, Mary Fei, Linda Lagasse, Edward Tronick, Dylan Guerin, Daniel Gorman, Carmen J. Marsit, Barry M. Lester
Prenatal Predictors Of Infant Self-Regulation: The Contributions Of Placental Dna Methylation Of Nr3c1 And Neuroendocrine Activity, Elisabeth Conradt, Mary Fei, Linda Lagasse, Edward Tronick, Dylan Guerin, Daniel Gorman, Carmen J. Marsit, Barry M. Lester
Dartmouth Scholarship
We examined whether placental DNA methylation of the glucocorticoid receptor gene, NR3C1 was associated with self-regulation and neuroendocrine responses to a social stressor in infancy. Placenta samples were obtained at birth and mothers and their infants (n = 128) participated in the still-face paradigm when infants were 5 months old. Infant self-regulation following the still-face episode was coded and pre-stress cortisol and cortisol reactivity was assessed in response to the still-face paradigm. A factor analysis of NR3C1 CpG sites revealed two factors: one for CpG sites 1-4 and the other for sites 5-13. DNA methylation of the factor comprising NR3C1 …
The Mammalian Neocortex New Pyramidal Neuron: A New Conception, Miguel Marín-Padilla
The Mammalian Neocortex New Pyramidal Neuron: A New Conception, Miguel Marín-Padilla
Dartmouth Scholarship
The new cerebral cortex (neocortex) and the new type of pyramidal neuron are mammalian innovations that have evolved for operating their increasing motor capabilities while essentially using analogous anatomical and neural makeups. The human neocortex starts to develop in 6-week-old embryos with the establishment of a primordial cortical organization, which resembles the primitive cortices of amphibian and reptiles. From the 8th to the 15th week of age, new pyramidal neurons, of ependymal origin, are progressively incorporated within this primordial cortex forming a cellular plate that divides its components into those above it (neocortex first layer) and those below it (neocortex …
Effects Of Socioeconomic Status On Brain Development, And How Cognitive Neuroscience May Contribute To Levelling The Playing Field, Rajeev Raizada, Mark M. Kishiyama
Effects Of Socioeconomic Status On Brain Development, And How Cognitive Neuroscience May Contribute To Levelling The Playing Field, Rajeev Raizada, Mark M. Kishiyama
Dartmouth Scholarship
The study of socioeconomic status (SES) and the brain finds itself in a circumstance unusual for Cognitive Neuroscience: large numbers of questions with both practical and scientific importance exist, but they are currently under-researched and ripe for investigation. This review aims to highlight these questions, to outline their potential significance, and to suggest routes by which they might be approached. Although remarkably few neural studies have been carried out so far, there exists a large literature of previous behavioural work. This behavioural research provides an invaluable guide for future neuroimaging work, but also poses an important challenge for it: how …