Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 4 of 4
Full-Text Articles in Computational Neuroscience
How To Search For The Engram: Optogenetics And Network Dynamics, Claudia Garcia Jou
How To Search For The Engram: Optogenetics And Network Dynamics, Claudia Garcia Jou
Dissertations, Theses, and Capstone Projects
Memories are thought to be encoded by ensembles of neurons called "engram cells", because their artificial activation with optogenetics leads to the behavioral expression of a memory. However, the physiological mechanisms that mediate this process remain unknown. In this thesis, I investigate how optogenetic stimulation of memory-tagged cells changes neuronal firing, spatial coding, and the geometry of neural manifolds. I used an active place avoidance task and a foraging task to label engram cells in the dorsal hippocampus with Channelrhodopsin2 (ChR2). I then recorded the hippocampal activity response to optogenetic stimulation in mice under anesthesia, head-fixed, or freely moving. I …
Accelerated Forgetting In People With Epilepsy: Pathologic Memory Loss, Its Neural Basis, And Potential Therapies, Sarah Ashley Steimel Phd
Accelerated Forgetting In People With Epilepsy: Pathologic Memory Loss, Its Neural Basis, And Potential Therapies, Sarah Ashley Steimel Phd
Dartmouth College Ph.D Dissertations
While forgetting is vital to human functioning, delineating between normative and disordered forgetting can become incredibly complex. This thesis characterizes a pathologic form of forgetting in epilepsy, identifies a neural basis, and investigates the potential of stimulation as a therapeutic tool. Chapter 2 presents a behavioral characterization of the time course of Accelerated Long-Term Forgetting (ALF) in people with epilepsy (PWE). This chapter shows evidence of ALF on a shorter time scale than previous studies, with a differential impact on recall and recognition. Chapter 3 builds upon the work in Chapter 2 by extending ALF time points and investigating the …
Investigating The Role Of Attention And Memory In Visual Exploration, Jacob E. Suffridge
Investigating The Role Of Attention And Memory In Visual Exploration, Jacob E. Suffridge
Graduate Theses, Dissertations, and Problem Reports (ETD)
This research investigates the role that attention and memory plays in visual exploration through a comprehensive analysis of eye movement and behavioral data, alongside incorporation of a computational saliency model. The purpose of this project is to quantify differences in visual attention over repeated viewings of natural scene images by employing a free viewing task that contains a memory component. In Chapter 2, we explore the task’s behavioral data showing that participants generally memorize our images well before we investigate the effect of numerous object and individual feature inclusion. In Chapter 3, we develop four primary methods to quantify visual …
What Makes An Image Memorable? Effects Of Encoding On The Mechanism Of Recognition, Asiya Gul
What Makes An Image Memorable? Effects Of Encoding On The Mechanism Of Recognition, Asiya Gul
Theses and Dissertations (Comprehensive)
Memory is undoubtedly one of the most important processes of human cognition. A long line of research suggests that recognition relies on the assessment of two explicit memory phenomena: familiarity and recollection. Researchers who support the Dual Process Signal Detection (DPSD) model of recognition memory link the FN400 component (a negative ERP deflection peaking around 400 ms at frontal electrodes) with familiarity; however, it is currently unclear whether the FN400 reflects familiarity or implicit memory. Three event-related potentials (ERP) studies were conducted to determine whether implicit memory plays a role in setting up encoding strategies, and how these encoding strategies …