Computational Neuroscience Commons^™

Tinnitus And Dysfunctional Interactions Between Distributed Resting State Networks, Sivayini Kandeepan

Western Research Forum

It is known that peripheral lesions in the cochlea or the auditory nerve produce dysfunctional input to central auditory structures and induce changes in the auditory system causing tinnitus. Recently, it has been proposed that the unified percept of tinnitus could be considered as an emergent property of multiple overlapping dynamic brain networks, each encoding a specific tinnitus characteristic.

The aim of our study was to investigate the neuronal activation patterns associated with specific clinical tinnitus characteristics using fMRI. We hypothesize that tinnitus clinical characteristics could be associated with specific resting-state activity and connectivity patterns and that this could be …

A Model Of Intracellular Θ Phase Precession Dependent On Intrinsic Subthreshold Membrane Currents., L Stan Leung

Physiology and Pharmacology Publications

A hippocampal place cell fires at an increasingly earlier phase in relation to the extracellular theta rhythm as a rodent moves through the place field. The present report presents a compartment model of a CA1 pyramidal cell that explains the increase in amplitude and the phase precession of intracellular theta oscillations, with the assumption that the cell receives an asymmetric ramp depolarization (<10 >mV) in the place field and rhythmic inhibitory and/or excitatory synaptic driving. Intracellular subthreshold membrane potential oscillations (MPOs) increase in amplitude and frequency, and show phase precession within the place field. Theta phase precession and MPO power …