The Role Of Glutamate In The Medial Prefrontal Cortex In The Acquistion And Expression Of Conditioned Approach, Rudolf Nisanov

Dissertations, Theses, and Capstone Projects

A series of experiments were conducted to assess the role of glutamatergic stimulation in the dorsal and ventral regions of the medial prefrontal cortex (mPFC) in both the acquisition and expression of reward-related learning using a Pavlovian conditioning paradigm, the conditioned-approach paradigm. Rats with surgically implanted cannulas were exposed to Pavlovian conditioning sessions that occurred on three alternative days (acquisition) or seven consecutive days (expression). These 60-min conditioning sessions consisted of 30 pairings of light (CS) and food pellets (US) presented under a random time schedule. After a two-day break, rats underwent a session with no CS or US and …

A Causal Inference Approach For Spike Train Interactions, Zach Saccomano

Dissertations, Theses, and Capstone Projects

Since the 1960s, neuroscientists have worked on the problem of estimating synaptic properties, such as connectivity and strength, from simultaneously recorded spike trains. Recent years have seen renewed interest in the problem coinciding with rapid advances in experimental technologies, including an approximate exponential increase in the number of neurons that can be recorded in parallel and perturbation techniques such as optogenetics that can be used to calibrate and validate causal hypotheses about functional connectivity. This thesis presents a mathematical examination of synaptic inference from two perspectives: (1) using in vivo data and biophysical models, we ask in what cases the …

The Effect Of Caffeine On Bee Behavior: A Progressive Ratio Study, Kayle Cohen, Becky Hansis-O'Neill, Aimee Dunlap Dr

Undergraduate Research Symposium

This presentation focuses on the effect of caffeine on bee behavior using behavioral pharmacology methodologies. Researchers trained bumblebees to drink out of artificial flowers, then administered sucrose nectar or caffeinated sucrose nectar during a schedule of progressive and fixed ratios. The finding suggests that caffeine did increase the number of rewards during the fixed ratio, but not in the progressive ratio. However, research is still ongoing as bees continue to be tested..

2023 Ulm Student Research Symposium Proceedings, Burton Ashworth

Multidisciplinary Psychology: A Journal of Collaboration

This is the results and proceedings from the 2023 ULM Student Research Symposium.

Neuropsychological Malingering Determination: The Illusion Of Scientific Lie Detection, Chunlin Leonhard, Christoph Leonhard

Georgia Law Review

Humans believe that other humans lie, especially when stakes are high. Stakes can be very high in a courtroom, from substantial amounts of monetary damages in civil litigation to liberty or life in criminal cases. One of the most frequently disputed issues in U.S. courts is whether litigants are malingering when they allege physical or mental conditions for which they are seeking damages or which would allow them to avoid criminal punishment. Understandably, creating a scientific method to detect lies is very appealing to all persons engaged in lie detection. Neuropsychologists claim that they can use neuropsychological assessment tests (Malingering …

The Effect Of Pornography On Marriage And Its Societal Impacts: A Neurobiological Perspective, Katie Rose Geer

NEXUS: The Liberty Journal of Interdisciplinary Studies

No abstract provided.

The Intersection Of Theatre And Cognitive Neuroscience, Mary Katherine Flage

NEXUS: The Liberty Journal of Interdisciplinary Studies

No abstract provided.

Cholinergic Activation Of Corticofugal Circuits In The Adult Mouse Prefrontal Cortex, Allan Gulledge

Dartmouth Scholarship

Acetylcholine (ACh) promotes neocortical output to the thalamus and brainstem by preferentially enhancing the postsynaptic excitability of layer 5 pyramidal tract (PT) neurons relative to neighboring intratelencephalic (IT) neurons. Less is known about how ACh regulates the excitatory synaptic drive of IT and PT neurons. To address this question, spontaneous excitatory postsynaptic potentials (sEPSPs) were recorded in dual recordings of IT and PT neurons in slices of prelimbic cortex from adult female and male mice. ACh (20 µM) enhanced sEPSP amplitudes, frequencies, rise-times, and half-widths preferentially in PT neurons. These effects were blocked by the muscarinic receptor antagonist atropine (1 …

Comparing Cognitive Tests And Smartphone-Based Assessment In 2 Us Community-Based Cohorts., Ileana De Anda-Duran, Preeti Sunderaraman, Edward Searls, Shirine Moukaled, Xuanyi Jin, Zachary Popp, Cody Karjadi, Phillip H Hwang, Huitong Ding, Sherral Devine, Ludy C Shih, Spencer Low, Honghuang Lin, Vijaya B Kolachalama, Lydia Bazzano, David J Libon, Rhoda Au

Rowan-Virtua School of Osteopathic Medicine Departmental Research

BACKGROUND: Smartphone-based cognitive assessments have emerged as promising tools, bridging gaps in accessibility and reducing bias in Alzheimer disease and related dementia research. However, their congruence with traditional neuropsychological tests and usefulness in diverse cohorts remain underexplored.

METHODS AND RESULTS: A total of 406 FHS (Framingham Heart Study) and 59 BHS (Bogalusa Heart Study) participants with traditional neuropsychological tests and digital assessments using the Defense Automated Neurocognitive Assessment (DANA) smartphone protocol were included. Regression models investigated associations between DANA task digital measures and a neuropsychological global cognitive

CONCLUSIONS: Our findings demonstrate that smartphone-based cognitive assessments exhibit concurrent validity with a …

Enhancing Proprioception And Regulating Cognitive Load In Neurodiverse Populations Through Biometric Monitoring With Wearable Technologies, James Hutson, Piper Hutson

Faculty Scholarship

This paper considers the realm of wearable technologies and their prospective applications for individuals with neurodivergent conditions, specifically Autism Spectrum Disorders (ASDs). The study undertakes a multifaceted analysis that encompasses biomarker sensing technologies, AI-driven biofeedback mechanisms, and haptic devices, focusing on their implications for enhancing proprioception and social interaction among neurodivergent populations. While wearables offer a range of opportunities for societal advancement, a discernable gap remains: a scarcity of consumer-oriented applications tailored to the unique physiological and psychological needs of these individuals. Key takeaways underscore the emergent promise of tailored auditory stimuli in workplace dynamics and the efficacy of haptic …

Precommentary: Animal Personality Needs Animal Sentience, Ralph Adolphs, Yue Xu

Animal Sentience

We are grateful to Owens, Bryja & Bekoff (2024) for their important discussion of individual differences in animals, emphasizing the role of personality in conservation, wildlife research, and wellbeing. But their emphasis also raises new challenges: How should we conceive of personality in nonhuman species? what modern tools could be leveraged to best measure it? and, perhaps most important of all: how can we ensure that the conscious experience of animals — their capacity for wellbeing and for suffering — is not forgotten along the way? We touch on each of these challenges in this invited Precommentary in the hope …

Adolescent Mental Health In The Twenty-First Century, Arthur Maerlander, Patricia Gail Bray

Center for Brain, Biology, and Behavior: Faculty Publications

Conclusion

Parents do not suddenly relinquish medical decision-making to their children and are a vital part of a process construed within the framework of consent and confidentiality laws. In the transition period from childhood to adulthood, adolescents develop unique healthcare needs and concerns at the very time they are gaining autonomy from their parents. Adolescents progress from being recipients of decisions about their care to gradually becoming active participants in their healthcare and emerge as a primary partner in medical decision-making. Building a strong therapeutic alliance with young people can help them become responsible healthcare decision-makers.

Yet while “healthcare,” including …

Associations Of Sex And Sport Contact‑Level With Recovery Timelines Among Collegiate Athletes With Sport‑Related Concussion, Bernadette A. D'Alonzo, Andrea L. C. Schneider, Ian J. Barnett, Christina L. Master, Abigail C. Bretzin, Douglas J. Wiebe, Ivy League-Big Ten Epidemiology Of Concussion Study Investigators

Center for Brain, Biology, and Behavior: Faculty Publications

Background

Growing interest has motivated recent studies to examine differences in recovery after sportrelated concussion (SRC) by sex. However, heterogeneity in study design, participants, and recovery outcomes has led to mixed findings. Further work is needed to evaluate potential differences by sex and to investigate the role of related characteristics, such as sport contact-level, in recovery timelines. This study aimed to investigate whether concussion recovery trajectories differ by sex, considering a priori clinical and demographic covariates, and accounting for the sequence of recovery outcomes. Our secondary question was whether sport contact-level modifies the relationship between sex and time to outcomes. …

Mechanosensory Encoding In Ex Vivo Muscle–Nerve Preparations, Stephen N. Housley, Evelyn A. Gardolinski, Paul Nardelli, J'Ana Reed, Mark M. Rich, Timothy C. Cope

Neuroscience, Cell Biology & Physiology Faculty Publications

Our objective was to evaluate an ex vivo muscle-nerve preparation used to study mechanosensory signalling by low threshold mechanosensory receptors (LTMRs). Specifically, we aimed to assess how well the ex vivo preparation represents in vivo firing behaviours of the three major LTMR subtypes of muscle primary sensory afferents, namely type Ia and II muscle spindle (MS) afferents and type Ib tendon organ afferents. Using published procedures for ex vivo study of LTMRs in mouse hindlimb muscles, we replicated earlier reports on afferent firing in response to conventional stretch paradigms applied to non-contracting, that is passive, muscle. Relative to in vivo …

The Protective Role Of Melanin Within The Teleost Inner Ear, Gabriel Heckerman

Mahurin Honors College Capstone Experience/Thesis Projects

Melanin is the dark pigment responsible for influencing the color of bodily structures, and it is variably present throughout human and animal tissue. Melanin is also found within the mammalian inner ear, and it has been observed that a lack of melanin is associated with greater susceptibility to sensorineural hearing loss. In this study, melanin levels of the inner ears of different color morphs of the fish species Poecilia latipinna and Cyprinus carpio were measured and the potential protective role of that melanin from acoustical stress was examined. Previous research showed that black morphs of both species exhibited less noise-induced …

Ribbon Synapses' Role In Synaptic Identification, Lauren Nguyen

Williams Honors College, Honors Research Projects

Understanding the impact of presynaptic and postsynaptic structures on synaptic strength, neurotransmission speed, and morphology is crucial. When cone photoreceptors transmit light-driven signals to cone bipolar cells, various presynaptic structural arrangements can be observed, featuring different numbers of synaptic ribbons. These ribbons facilitate faster initial excitation and sustained transmitter release as vesicles dock at ribbon synapses.

To investigate these structures, I will use the WEBKNOSSOS program to trace dendrites in vertebrate retinal images, determining the number of ribbon synapses and neuron types. This research, building upon the work of Dr. Wan-Qing Yu and Swanstrom, is expected to take about a …

Behavioral Responses To Chronic And Acute Stressors In Prairie Voles, Yessenia Chavez

Graduate Research Theses & Dissertations

Social isolation has several psychological and physiological consequences including anxiety and depressive-like behaviors, rapid heart rate (HR), and elevated blood pressure. Social isolation also combines with acute environmental stress to influence emotions and behaviors. The present study evaluated behavioral responses to a combination of long-term social stress and acute stress in the prairie vole rodent model, and whether an environmental treatment could protect against anxiety-related consequences of acute and social stress. Prairie voles engage in social behaviors translational to humans, including monogamous relationships, and provide a valuable model for investigating the interactions of social stress and acute environmental stress. In …

Cancer Research Provides A Model For Advancing Clinical Trials In Dementia In The Era Of Disease-Modifying Alzheimer’S-Type Dementia Therapies, Gregory Jicha, Thomas Tucker, Susanne Arnold, Peter T. Nelson

Neurology Faculty Publications

Dementia and cancer are multifactorial, widely-feared, age-associated clinical syndromes that are increasing in prevalence. There have been major breakthroughs in clinical cancer research leading to some effective treatments, whereas the field of dementia has achieved comparatively limited success in clinical research. The lessons of cancer research may help those in the dementia research field in confronting some of the dilemmas faced when the clinical care regimen is not entirely safe or efficacious. Cancer clinical trials have assumed that untreated individuals with cancer are at high risk for morbidity and mortality after primary diagnoses. Thus, patients deserve a choice of clinical …

Nalfurafine Promotes Myelination In Vitro And Facilitates Recovery From Cuprizone + Rapamycin-Induced Demyelination In Mice, Ross Van De Wetering, Rabia Bibi, Andy Biggerstaff, Sheein Hong, Bria Pengelly, Thomas E. Prisinzano, Anne C. La Flamme, Bronwyn M. Kivell

Markey Cancer Center Faculty Publications

The kappa opioid receptor has been identified as a promising therapeutic target for promoting remyelination. In the current study, we evaluated the ability of nalfurafine to promote oligodendrocyte progenitor cell (OPC) differentiation and myelination in vitro, and its efficacy in an extended, cuprizone-induced demyelination model. Primary mouse (C57BL/6J) OPC-containing cultures were treated with nalfurafine (0.6–200 nM), clemastine (0.01–100 μM), T3 (30 ng/mL), or vehicle for 5 days. Using immunocytochemistry and confocal microscopy, we found that nalfurafine treatment increased OPC differentiation, oligodendrocyte (OL) morphological complexity, and myelination of nanofibers in vitro. Adult male mice (C57BL/6J) were given a diet con- taining …

U.S. Public Perceptions Of The Sensitivity Of Brain Data, Shenyang Huang, Umika Paul, Shikhar Gupta, Karan Desai, Melinda Guo, Jennifer Jung, Beatrice Capestany, William D. Krenzer, Dylan Stonecipher, Nita A. Farahany

Faculty Scholarship

As we approach an era of potentially widespread consumer neurotechnology, scholars and organizations worldwide have started to raise concerns about the data privacy issues these devices will present. Notably absent in these discussions is empirical evidence about how the public perceives that same information. This article presents the results of a nationwide survey on public perceptions of brain data, to inform discussions of law and policy regarding brain data governance. The survey reveals that the public may perceive certain brain data as less sensitive than other ‘private’ information, like social security numbers, but more sensitive than some ‘public’ information, like …

Translational Neuroscience Contributes To Understanding Neurodevelopmental Outcomes Of Dostoyevsky's "Brothers Karamazov" With Treatment Implications, Stephen I. Deutsch, Jessica A. Burket, Jeffrey Elikan Jd, David R. Spiegel

Department Psychiatry & Behavioral Science Faculty Publications

Dostoyevsky's novels raise profound ethical, moral, philosophical and theological issues and, as a result, both he and his novels serve as fertile subjects of scholarly inquiry across a variety of academic disciplines. In particular, major characters in "The Brothers Karamazov" lend themselves to classical psychodynamic formulations, such as the influence of adverse childhood experiences on adult social and occupational outcomes, which in the case of Dmitry, the eldest son of Fyodor Pavlovich Karamazov, are considered in exquisitely fine detail. Prosecutor and defense attorney provide differing interpretations of how early traumas, largely due to paternal neglect and abuse, affected Dmitry's adult …

An Efficient And High-Throughput Method For The Evaluation Of Mitochondrial Dysfunction In Frozen Brain Samples After Traumatic Brain Injury., Hemendra J Vekaria, Olivia J. Kalimon, Paresh Prajapati, Gopal V. Velmurugan, Patrick G Sullivan

Neuroscience Faculty Publications

Mitochondrial function analysis is a well-established method used in preclinical and clinical investigations to assess pathophysiological changes in various disease states, including traumatic brain injury (TBI). Although there are multiple approaches to assess mitochondrial function, one common method involves respirometric assays utilizing either Clark-type oxygen electrodes or fluorescent-based Seahorse analysis (Agilent). However, these functional analysis methods are typically limited to the availability of freshly isolated tissue samples due to the compromise of the electron transport chain (ETC) upon storage, caused by freeze-thaw-mediated breakdown of mitochondrial membranes. In this study, we propose and refine a method for evaluating electron flux through …

When Brain Meets Artificial Intelligence, Lu Zhang

Computer Science and Engineering Dissertations - Archive

When we review the history of development of artificial intelligence (AI), we will find that brain science plays a pivotal role in fostering breakthroughs in AI, such as artificial neural networks (ANNs). Today, AI has made remarkable strides, particularly with the emergence of large language models (LLMs), surpassing expectations and achieving human-level performance in certain tasks. Nonetheless, an insurmountable gap remains between AI and human intelligence. It is urgent to establish a bridge between brain science and AI, promoting their mutual enhancement and collaborations. This involve establishing connections from brain science to AI (brain-inspired AI), and reversely, from AI to …

Calcium And Proteasomal Regulation Of Er-To-Golgi Protein Transport In Neurons, Samuel A. Galindo

Undergraduate Theses, Professional Papers, and Capstone Artifacts

Regulatory mechanisms of protein trafficking from the endoplasmic reticulum (ER) are critical to understand since neurodegenerative diseases involve defects in this process leading to chronic ER stress and cell death. This study aimed to better understand the calcium regulatory mechanisms of ER-to-Golgi trafficking in hybrid neuroglioblastoma cells (NG108). Specifically, we asked whether proteasomal degradation of transport machinery was involved in the previously demonstrated upregulation of ER-to-Golgi transport evoked by calcium signaling. Based upon previous literature, we believe that the calcium induced increase in transport is due to the activation of the calcium sensitive regulatory protein apoptosis linked gene 2 (ALG-2) …

The Effects Of Early Exposure To Prescription/Illicit Drugs And Drug Metabolites On Larval Zebrafish Behavioral And Motor Function Development, Jacob Thomas, Dena Weinberger, Bikram Subedi, Brandon Capps

Murray State Theses and Dissertations

THE EFFECTS OF EARLY EXPOSURE TO PRESCRIPTION/ILLICIT DRUGS AND DRUG METABOLITES ON LARVAL ZEBRAFISH BEHAVIORAL AND MOTOR FUNCTION DEVELOPMENT

A Thesis Presented to the Faculty of the Department of Biology

Murray State University

Murray, Kentucky

In Partial Fulfillment of the Requirements for the Degree of Masters In Science

By Jacob Thomas, B.S., Murray State University

December 2024

Acknowledgements

Brandon Capps, who pretty much did a whole third of the legwork on this project and saved me lots of headaches;

Chandler Maddox, one of the University of Kentucky’s finest undergrads who came in from the top rope with a folding chair …

Neurocinematics And Empathy: How Cognitive Neuroscience Enhances Our Understanding Of Emotional Responses Of Film, Kira Trinity

Cal Poly Humboldt theses and projects

Cinema is a medium that is beloved around the globe since its inception over a century ago. There have been speculations on how it is that cinema works, from editing to emotional processing of the story, but only recently have we begun to explore the inner workings of cinematic impact on the brain. In this paper we will review research on cinematic impact and define cinematic editing, discuss the birth of “neurocinematics”, highlight what we have observed with regards to neuroimaging and empathy when viewing films, and speculate on how our responses to cinema may be driven by the Mirror …

The Standing Of Anger: Insights From The Debate(S) On Constructed Emotion, Andrew Holzer

CMC Senior Theses

In her book, Anger and Forgiveness: Resentment, Generosity, Justice, Martha Nussbaum argues that anger is inherently flawed because it fundamentally contains the desire for payback. To support her argument, she posits specific metaphysical claims about the nature of emotions like anger. This thesis is an extended critique of her metaphysical foundation from the perspective of empirical research in the neuroscience of emotion. The first reason to dispute this picture is descriptive; this view of anger is based on an outdated version of cognitive appraisal theory, which sees emotions as triggered directly by static moments of cognitive appraisal. The second …

Heightened Neural Activity And Functional Connectivity Responses To Social Rejection In Female Adolescents At Risk For Depression: Testing The Social Signal Transduction Theory Of Depression, Grant S. Shields, Meghan Vinograd, Theresa Bui, Stassja Sichko, Michael R. Irwin, George M. Slavich

Psychological Science Faculty Publications and Presentations

Background

Method

Investigation Of Brain Function And Structural Development As Risk Factors Of Suicidal Thoughts And Behaviors, Yi Zhou

Theses and Dissertations

Background: Identifying risk factors for suicidal thoughts and behaviors, especially causal ones, will be imperative to improving screening and treatment interventions. To identify replicable brain-based risk factors, there is increasing evidence indicating the need for large sample sizes, in the hundreds to thousands, in order to achieve a sufficient level of statistical power to detect them. Furthermore, longitudinal studies of brain and behavioral factors will be essential to understanding how suicide develops, especially the transition from suicide ideation to attempt. While experimental studies may not be feasible or ethical, genetically informed methods for testing evidence for causation are an alternative …

Here Come The Test Results: An Analysis Of Games In Experimental Design For Neuroscience Research, Madison Mcdougall

Scripps Senior Theses

A large part of experimental design in neuroscience revolves around the tasks that are designed for participants to complete to understand the complex system that is the brain. However, as Alan Newell pointed out in his 1973 paper, “You can’t play 20 questions with nature and win,” as designed tasks often answer a binary question that limits their contribution to understanding the brain as a system or a “genuine slab of human behavior.” Games provide an apt solution to this problem, as their complexity embodies a naturalistic task while their well-defined rules create a robust experimental system. Video games specifically …