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Neuroscience and Neurobiology Commons™
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Articles 211 - 240 of 407
Full-Text Articles in Neuroscience and Neurobiology
Effects Of Repeated Nicotine Vapor Exposure And Withdrawal On Somatic Signs, Anxiety-Like Behavior, And Brain Reward Thresholds In Male Sprague Dawley Rats, Michelle Martinez
Effects Of Repeated Nicotine Vapor Exposure And Withdrawal On Somatic Signs, Anxiety-Like Behavior, And Brain Reward Thresholds In Male Sprague Dawley Rats, Michelle Martinez
Open Access Theses & Dissertations
No abstract provided.
Vitamin B12 Deficiency Does Not Stimulate Amyloid-Beta Toxicity In A Ceanorhabditis Elegans Model Of Alzheimer’S Disease, Opeyemi F. Showemimo
Vitamin B12 Deficiency Does Not Stimulate Amyloid-Beta Toxicity In A Ceanorhabditis Elegans Model Of Alzheimer’S Disease, Opeyemi F. Showemimo
Electronic Theses and Dissertations
Alzheimer’s disease (AD) is symptomized by amyloid-beta plaques in the brain and accounts for more than 65 percent of dementia cases. Vitamin B12 (cobalamin) deficiency can result in similar cognitive impairment and roughly 15% of the elderly are vitamin B12 deficient. Vitamin B12 deficiency results in the accumulation of toxic methylmalonic acid and homocysteine. Hyperhomocysteinemia is a strong risk factor for AD. To test if vitamin B12 deficiency stimulates amyloid-beta toxicity, Caenorhabditis elegans expressing amyloid-beta in muscle were fed either vitamin B12-deficient OP50-1 or vitamin B12-rich HT115(DE3) E. coli bacteria. Increased amyloid-beta toxicity was found in worms fed the …
Reduced Adaptation Of Glutamatergic Stress Response Is Associated With Pessimistic Expectations In Depression, Jessica A. Cooper, Makiah R. Nuutinen, Victoria M. Lawlor, Brittany A.M. Devries, Elyssa M. Barrick, Shabnam Hossein, Daniel J. Cole, Chelsea V. Leonard, Evan C. Hahn, Andrew P. Teer, Grant S. Shields, George M. Slavich, Dost Ongur, J. Eric Jensen, Fei Du, Diego A. Pizzagalli, Michael T. Treadway
Reduced Adaptation Of Glutamatergic Stress Response Is Associated With Pessimistic Expectations In Depression, Jessica A. Cooper, Makiah R. Nuutinen, Victoria M. Lawlor, Brittany A.M. Devries, Elyssa M. Barrick, Shabnam Hossein, Daniel J. Cole, Chelsea V. Leonard, Evan C. Hahn, Andrew P. Teer, Grant S. Shields, George M. Slavich, Dost Ongur, J. Eric Jensen, Fei Du, Diego A. Pizzagalli, Michael T. Treadway
Psychological Science Faculty Publications and Presentations
Stress is a significant risk factor for the development of major depressive disorder (MDD), yet the underlying mechanisms remain unclear. Preclinically, adaptive and maladaptive stress-induced changes in glutamatergic function have been observed in the medial prefrontal cortex (mPFC). Here, we examine stress-induced changes in human mPFC glutamate using magnetic resonance spectroscopy (MRS) in two healthy control samples and a third sample of unmedicated participants with MDD who completed the Maastricht acute stress task, and one sample of healthy control participants who completed a no-stress control manipulation. In healthy controls, we find that the magnitude of mPFC glutamate response to the …
Effects Of A Play-Based Intervention On Locomotor Skills And Strength Performance Of Children With Autism Spectrum Disorder, Amber Bardsley
Effects Of A Play-Based Intervention On Locomotor Skills And Strength Performance Of Children With Autism Spectrum Disorder, Amber Bardsley
Honors Scholar Theses
Emerging evidence indicates that around 80-100% of children with autism spectrum disorder (ASD) have motor impairments in gross motor skills, strength, and endurance. In the current study, which is a multisite collaboration with the physical therapy programs at the University of Connecticut and the University of Delaware, we are assessing the effects of two types of movement-based interventions compared to a standard-of-care seated play control intervention on motor performance in children with ASD. This thesis will analyze data from one of the movement training groups, i.e., the play group, that involved children engaging in activities based on music, dance, and …
The Development And Evaluation Of Novel Da Transport Inhibitors And Their Effects On Effort-Related Motivation: A Review, Mukund Desibhatla
The Development And Evaluation Of Novel Da Transport Inhibitors And Their Effects On Effort-Related Motivation: A Review, Mukund Desibhatla
Honors Scholar Theses
Depression is a debilitating disorder that can cause motivational deficits such as psychomotor retardation, anergia, apathy, and fatigue. Recent research indicates that these motivational deficits, and potential pathways of therapeutic intervention, can be studied in animal models involving rats and mice. Treatments with the VMAT-2 inhibitor tetrabenazine (TBZ) and cytokine interleukin-1ß (IL-1ß) can create a low-effort bias and impair effort-related motivation (Nunes et al. 2013, 2014). A number of high-affinity DA transport inhibitors such as d-amphetamine, methylphenidate, and cocaine can restore extracellular DA, albeit with the cost of undesirable effects such as high abuse liability. These observations have led researchers …
An Eeg Source-Space Analysis Of The Neural Correlates Underlying Self-Regulation, Stephanie M. Long
An Eeg Source-Space Analysis Of The Neural Correlates Underlying Self-Regulation, Stephanie M. Long
Graduate Theses and Dissertations
Self-regulation is the cognitive process of controlling our thoughts and behaviors to be aligned with our goals. This process is used in many different contexts and has been associated with contributions from several brain regions. This research aimed to investigate differences in four prefrontal areas of the brain while participants applied four different self-regulation strategies. We recorded EEG while participants (N = 132) performed three tasks which engaged each of the four self-regulation strategies: the AX-CPT task engaged proactive and reactive control, the Go/Nogo task engaged inhibitory control, and the hybrid Flanker Global/Local task engaged the resolution of response conflict. …
You Might Think This Article Is About You: A Neurological Overview Of Narcissistic Personality Disorder, Kaitlyn Griffith
You Might Think This Article Is About You: A Neurological Overview Of Narcissistic Personality Disorder, Kaitlyn Griffith
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
Loosen Up, Sleep Tight: How Relaxation Techniques May Be The Solution To Stress-Induced Insomnia, Afomia Ayele
Loosen Up, Sleep Tight: How Relaxation Techniques May Be The Solution To Stress-Induced Insomnia, Afomia Ayele
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
Soak Up The Sun: How Sun Affects And Protects The Brain, Benjamin Dorfman
Soak Up The Sun: How Sun Affects And Protects The Brain, Benjamin Dorfman
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
Stress, Stress, The More You Drink The Better You Feel, But Let's Not Have Alcohol For Every Meal, Elena Schaub
Stress, Stress, The More You Drink The Better You Feel, But Let's Not Have Alcohol For Every Meal, Elena Schaub
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
The Brain And Swiping For Love, Samantha Beck
The Brain And Swiping For Love, Samantha Beck
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
Actually, Say Yes To Dope: A Much-Maligned Drug May Be The Key To Saving The Brain From Concussions, Charles Adams
Actually, Say Yes To Dope: A Much-Maligned Drug May Be The Key To Saving The Brain From Concussions, Charles Adams
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
Are We There Yet? How Our Brains Understand Time, Laura Grosh
Are We There Yet? How Our Brains Understand Time, Laura Grosh
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
A Look Into The Crystal Ball: Should Genetic Testing Tell Your Future?, Elisabeth Bradford
A Look Into The Crystal Ball: Should Genetic Testing Tell Your Future?, Elisabeth Bradford
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
Separation Of Art And Science, That's A Wap (Wasted Academic Potential), Amna Tahir
Separation Of Art And Science, That's A Wap (Wasted Academic Potential), Amna Tahir
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
Cheese, Please! Depression Curing Cultures: How Diet Can Alter Your Mood, Julia Borys
Cheese, Please! Depression Curing Cultures: How Diet Can Alter Your Mood, Julia Borys
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
The Enemy Of My Enemy Is My Friend? How Viruses Can Be Used To Treat Brain Cancer, Kai Wilczewski-Shirai
The Enemy Of My Enemy Is My Friend? How Viruses Can Be Used To Treat Brain Cancer, Kai Wilczewski-Shirai
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
Scientific Kenyon: Neuroscience Edition (Full Issue)
Scientific Kenyon: Neuroscience Edition (Full Issue)
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
Worrisome Weight Gain: How Stress Affects Eating Behavior, Madison Ladd
Worrisome Weight Gain: How Stress Affects Eating Behavior, Madison Ladd
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
It's Not You, It's Me (Your Genes), Gillian Heckler
It's Not You, It's Me (Your Genes), Gillian Heckler
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
Closed Eyes, Open Mind: An Exploration Of Consciousness, Arlo Durham
Closed Eyes, Open Mind: An Exploration Of Consciousness, Arlo Durham
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
Head To Head: How Concussion Research Shapes How We Play Football, Jaryd Jones
Head To Head: How Concussion Research Shapes How We Play Football, Jaryd Jones
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
Mind Control 101: A Recipe For Memory Manipulation, Richard Fu
Mind Control 101: A Recipe For Memory Manipulation, Richard Fu
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
From Stagger To Swagger, Frank Zhao
From Stagger To Swagger, Frank Zhao
Scientific Kenyon: The Neuroscience Edition
No abstract provided.
Investigating Mechanisms In Nociceptors Driving Ongoing Activity And Ongoing Pain, Elia Lopez
Investigating Mechanisms In Nociceptors Driving Ongoing Activity And Ongoing Pain, Elia Lopez
Dissertations and Theses (Open Access)
Ongoing (apparently spontaneous) pain at rest is a major complaint of patients suffering from many forms of acute and chronic pain, including acute and persistent postsurgical pain. Accumulating evidence suggests ongoing activity in nociceptors is a major driver of ongoing pain. Ongoing activity can be generated in sensory neurons in the absence of sensory generator potentials if one or more of three neurophysiological alterations occur – prolonged depolarization of resting membrane potential (RMP), hyperpolarization of action potential (AP) threshold, and/or increased amplitude of depolarizing spontaneous fluctuations of membrane potential (DSFs) to bridge the gap between RMP and AP threshold. Cellular …
Cortical Dynamics Of Language, Kiefer Forseth
Cortical Dynamics Of Language, Kiefer Forseth
Dissertations and Theses (Open Access)
The human capability for fluent speech profoundly directs inter-personal communication and, by extension, self-expression. Language is lost in millions of people each year due to trauma, stroke, neurodegeneration, and neoplasms with devastating impact to social interaction and quality of life. The following investigations were designed to elucidate the neurobiological foundation of speech production, building towards a universal cognitive model of language in the brain. Understanding the dynamical mechanisms supporting cortical network behavior will significantly advance the understanding of how both focal and disconnection injuries yield neurological deficits, informing the development of therapeutic approaches.
Characterization Of A Novel Oncogenic Mirna Inhibitor In Cancer Therapy, Iman Sahnoune
Characterization Of A Novel Oncogenic Mirna Inhibitor In Cancer Therapy, Iman Sahnoune
Dissertations and Theses (Open Access)
As cancer research continues to move towards more personalized methods, targeted inhibitors of oncogenic drivers of cancer are found to be an innovative and promising therapeutic approach. Previously thought to be undruggable regions of the genome, RNA has become an area of increasing interest in cancer due to the identification of more targetable regions and their relationship to tumor growth and progression. This work reports on the development of IACS-13743, a novel small molecule found to directly bind and inhibit microRNA-10b. Oncogenic miR-10b has been found to be overexpressed in several malignant cancer types, making it an attractive biomarker for …
Development Of A Novel Cognitive-Motor Dual Task Assessment Battery In Neurodegenerative Disease, Jason Longhurst
Development Of A Novel Cognitive-Motor Dual Task Assessment Battery In Neurodegenerative Disease, Jason Longhurst
UNLV Theses, Dissertations, Professional Papers, and Capstones
Automaticity --- the ability to perform a task with directing attentional resources to its completion --- is commonly reduced among individuals with neurodegenerative diseases. These automaticity deficits result in impaired functional and daily activities and are sensitive to subtle, subclinical impairments. However, current measurement of automaticity by dual task paradigms is methodologically limited. In order to gain insight into the current state of the literature regarding cognitive-motor interference in symptomatic and prodromal neurodegenerative disease, the author of this dissertation conducted a scoping review (Chapter 1). To address the methodological limitations of current measurement of automaticity, a new measurement tool was …
Meta-Analysis Of Long Term Executive Functioning Deficits In Individuals With Mild Traumatic Brain Injuries, Dominique Ballinger
Meta-Analysis Of Long Term Executive Functioning Deficits In Individuals With Mild Traumatic Brain Injuries, Dominique Ballinger
Neuroscience Honors Papers
Performed a meta-analysis of studies examining the long-term executive functioning deficits after suffering several mild traumatic brain injuries. Data was collected from multiple primary sources under several, specific criteria to find the best methods in demonstrating the longevity and urgencies in suffering several mTBIs.