Neuroscience and Neurobiology Commons^™

Axonal Regrowth Of Olfactory Sensory Neurons After Chemical Ablation And Removal Of Axonal Debris By Microglia, Rudy Chapman

Electronic Theses and Dissertations

Olfactory sensory neurons (OSNs) are contained within the olfactory epithelium (OE) and are responsible for detecting odorant molecules in the air. The exposure of OSNs to the external environment is necessary for their function, but it also leaves them exposed to potentially harmful elements and thus results in a high turnover rate. Despite the high turnover, the olfactory sense is maintained throughout life through the division of a population of stem cells that produce new OSNs both during normal turnover and after an injury occurs in the OE. When new OSNs are born, they must extend axons from the OE …

The Influence Of Cerebellar Transcranial Direct Current Stimulation On Motor Function In Parkinson’S Disease, Lidio Lima De Albuquerque

UNLV Theses, Dissertations, Professional Papers, and Capstones

Parkinson's disease (PD) is the most common movement disorder and the second most common neurodegenerative disorder. PD is characterized by dopaminergic cell loss in the substantia nigra pars compacta, which leads to a reduction in dopamine in the striatum. These physiological mechanisms lead to a number of motor impairments such as bradykinesia, rigidity, tremor, and postural instability that severely limit the ability of individuals with PD to perform many essential daily living activities. Although current pharmacological, surgical, and physical exercise treatment approaches are valuable they are either only mildly effective, expensive, or associated with a variety of side effects. Therefore, …

Elevated Cochlear Adenosine Causes Hearing Loss Via Adora2b Signaling, Jeanne Manalo

Dissertations and Theses (Open Access)

Over 538 million people in the world have been diagnosed with hearing loss (HL). Current treatments for the most common type of HL, sensorineural HL, are limited to hearing aids and cochlear implants with no FDA-drugs available. The hearing process demands an abundance of ATP and HL is often attributed to a disruption in this metabolic energy currency. Patients who lack adenosine deaminase (ADA), the enzyme that irreversibly metabolizes adenosine, have high levels of adenosine that yield severe health problems, including HL; however, the pathogenic mechanisms behind HL and adenosine remain elusive. Our lab has found a HL phenotype in …

Effects Of Prenatal Exposure To Phenobarbital On Verbal Abilities In School-Aged Children, Jocelyn M. Lutes

Graduate Masters Theses

Phenobarbital is one of the oldest medications used for the treatment of epilepsy. Although its use has declined in many developed nations, phenobarbital is still a first-line treatment in several developing countries across the globe. If possible, current American Academy of Neurology guidelines advise against the use of phenobarbital during pregnancy due to an increased risk for structural malformations. However, less is known about the risk that prenatal exposure to phenobarbital poses to the cognitive and behavioral development of the child. Adams et al (in progress) have shown that, in comparison to demographically matched controls, children prenatally exposed to phenobarbital …

Consider The Agent In The Arthropod, Nicolas Delon, Peter Cook, Gordon Bauer, Heidi Harley

Animal Sentience

Whether or not arthropods are sentient, they can have moral standing. Appeals to sentience are not necessary and retard progress in human treatment of other species, including invertebrates. Other increasingly well-documented aspects of invertebrate minds are pertinent to their welfare. Even if arthropods are not sentient, they can be agents whose goals—and therefore interests—can be frustrated. This kind of agency is sufficient for moral status and requires that we consider their welfare.

What Kind Of An Illusion Is The Illusion Of Self, Karsten J. Struhl

Comparative Philosophy

Both early and later forms of Buddhism developed a set of arguments to demonstrate that the self is an illusion. This article begins with a brief review of some of the arguments but then proceeds to show that these arguments are not themselves sufficient to dispel the illusion. It analyzes three ways in which the illusion of self manifests itself – as wish fulfillment, as a cognitive illusion, and as a phenomenal illusion (what might be called the “I” sense). With respect to this last, the article reviews some recent developments in cognitive neuropsychology and neuroscience to discuss the way …

Variations In Slow-Wave Eeg And Working Memory Deficits During Letter Number Sequencing Task Post-Concussion, Morgan Sotoloff

Neuroscience Presentations

Concussions are associated with various types of consequences, both short-term and long-term: ranging from acute symptomatology, resting protocols, return-to-play decisions, and the lingering effects that have been found to have significant impacts on cognitive processes and function in many individuals several months post-concussion. Previous research has demonstrated that certain dimensions of executive function are especially susceptible to mild traumatic brain injury (mTBI), specifically working memory and attention. Studies that have previously utilized electroencephalography (EEG), have found that increased very low frequency oscillations (VLFO) are associated with a disruption of goal-oriented activities, difficulties in cognition, hyperactivity, and inattention in concussed individuals …

Wild Mice With Different Social Network Sizes Vary In Brain Gene Expression, Patricia C. Lopes, Barbara König

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Background

Appropriate social interactions influence animal fitness by impacting several processes, such as mating, territory defense, and offspring care. Many studies shedding light on the neurobiological underpinnings of social behavior have focused on nonapeptides (vasopressin, oxytocin, and homologues) and on sexual or parent-offspring interactions. Furthermore, animals have been studied under artificial laboratory conditions, where the consequences of behavioral responses may not be as critical as when expressed under natural environments, therefore obscuring certain physiological responses. We used automated recording of social interactions of wild house mice outside of the breeding season to detect individuals at both tails of a distribution …

Proceedings From The First Annual Society For Neurosports Conference, William R. Kochen

Journal for Sports Neuroscience

Proceedings from the First Annual Society for NeuroSports Conference

Brain Complexity, Sentience And Welfare, Donald M. Broom

Animal Sentience

Neither sentience nor moral standing is confined to animals with large or human-like brains. Invertebrates deserve moral consideration. Definition of terms clarifies the relationship between sentience and welfare. All animals have welfare but humans give more protection to sentient animals. Humans should be less human-centred.

Convergent Evolution Of Sentience?, Culum Brown Prof.

Animal Sentience

Mikhalevich & Powell make a compelling case that some invertebrates may be sentient and that our moral obligations in the context of welfare should hence extend to them. Although the case is similar to that made for fishes, there is one obvious difference in that examples of invertebrate sentience probably arose independently from vertebrate sentience. We have unequivocal proof that complex cognition arose multiple times over evolutionary history. Given that cognition is our best tool for indirectly quantifying sentience, it seems highly likely that this multiple polygenesis may also have occurred for sentience. In acknowledging this, we must accept that …

Minds, Morality And Midgies, Brian Key, Deborah Brown

Animal Sentience

Mikhalevich & Powell argue that the exclusion of the vast majority of arthropods from moral standing is unwarranted, particularly given the purported evidence for cognition and sentience in these organisms. The implied association between consciousness and moral standing is questionable and their assumption that rich forms of cognition and flexible behavior are dependent on phenomenal consciousness needs to be reconsidered in light of current neuroscientific evidence. We conclude by proposing a neural algorithmic approach for deciphering whether organisms are capable of subjective experience.

Olfaction Modulates Inter-Subject Correlation Of Neural Responses, Paul Deguzman, Anshul Jain, Matthias H. Tabert, Lucas C. Parra

Publications and Research

Odors can be powerful stimulants. It is well-established that odors provide strong cues for recall of locations, people and events. The effects of specific scents on other cognitive functions are less well-established. We hypothesized that scents with different odor qualities will have a different effect on attention. To assess attention, we used Inter-Subject Correlation of the EEG because this metric is strongly modulated by attentional engagement with natural audiovisual stimuli.We predicted that scents known to be “energizing” would increase Inter-Subject Correlation during watching of videos as compared to “calming” scents. In a first experiment, we confirmed this for eucalyptol and …

Her9/Hes4 Is Required For Retinal Photoreceptor Development, Maintenance, And Survival, Cagney E. Coomer, Stephen G. Wilson, Kayla F. Titialii-Torres, Jessica D. Bills, Laura A. Krueger, Rebecca A. Petersen, Evelyn M. Turnbaugh, Eden L. Janesch, Ann C. Morris

Biology Faculty Publications

The intrinsic and extrinsic factors that regulate vertebrate photoreceptor specification and differentiation are complex, and our understanding of all the players is far from complete. Her9, the zebrafish ortholog of human HES4, is a basic helix-loop-helix-orange transcriptional repressor that regulates neurogenesis in several developmental contexts. We have previously shown that her9 is upregulated during chronic rod photoreceptor degeneration and regeneration in adult zebrafish, but little is known about the role of her9 during retinal development. To better understand the function of Her9 in the retina, we generated zebrafish her9 CRISPR mutants. Her9 homozygous mutants displayed striking retinal phenotypes, including decreased …

Anatomical Organization And Distinction Of The Sympathetic Inputs To Interscapular Brown Adipose Tissue And Inguinal White Adipose Tissue In The Mouse, Clara Jane Huesing

LSU Doctoral Dissertations

Adipose tissue is a dynamic endocrine organ that contains both the problem and the solution to discovering new therapies for individuals with obesity. Excessive adipose tissue disrupts energy balance and causes a host of comorbidities like insulin resistance and hypertension. On the other hand, adipose tissue is essential for life. During periods of energy demand, sympathetic nerve activity in brown and white adipose tissue stimulates thermogenesis and lipolysis; both of which decrease body weight and improve metabolic health. Therefore, comprehensive insight into the organization of sympathetic innervation and how it communicates with adipocytes is critical in order to utilize its …

Secrets Of Slumber: How Do We Get A Good Night’S Sleep?, Srila Chadalavada

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Cognitive Stimulation As A Mechanism Linking Socioeconomic Status With Executive Function: A Longitudinal Investigation, Maya L. Rosen, Mckenzie P. Hagen, Lucy A. Lurie, Zoe E. Miles, Margaret A. Sheridan, Andrew N. Meltzoff, Katie A. Mclaughlin

Neuroscience: Faculty Publications

Executive functions (EF), including working memory, inhibition, and cognitive flexibility, vary as a function of socioeconomic status (SES), with children from economically disadvantaged backgrounds having poorer performance than their higher SES peers. Using observational methods, we investigated cognitive stimulation in the home as a mechanism linking SES with EF. In a sample of 101 children aged 60–75 months, cognitive stimulation fully mediated SES-related differences in EF. Critically, cognitive stimulation was positively associated with the development of inhibition and cognitive flexibility across an 18-month follow-up period. Furthermore, EF at T1 explained SES-related differences in academic achievement at T2. Early cognitive stimulation—a …

Ocd-Adhd Together: A Walking Contradiction, Chloe Hall

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Daydreaming Of Genius: Insight And The Wandering Mind, Kevin Crawford

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Poppies, Pain, And Public Health Crises: How Pain Treatment Shaped The American Opioid Epidemic, Lindsay Spitz

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Past Lives: How Intergenerational Trauma Shapes Mental Health, Ariel Neumann

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Contents

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

No Need To Fear, The Glial Scar Is Here, Lauren Graf

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

This Is Your Mood On Drugs, Adam Roesner

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Let's Talk About Sex: Differences In The Expression And Experience Of Autism Based On Sex, Sarah Hudson

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Let There Be Light: Optogenetic Treatment Of Blindness, Mara Kaspers

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Sleep It Off: How Sleep Quality Influences Outcomes Of Traumatic Brain Injury, Greg Boyer

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Emphatic About The Glymphatic: The Brain's Waste Removal System As Therapy For Alzheimer's Disease, Katrina Simchick

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

The Winter Blues: Are You Sad?, Caitlyn Haas

Scientific Kenyon: The Neuroscience Edition

No abstract provided.

Thinking Juul Is Cool? The Real Truth About E-Cigarettes & Vaping, Julia Green

Scientific Kenyon: The Neuroscience Edition

No abstract provided.