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Neuroscience and Neurobiology Commons™

Open Access. Powered by Scholars. Published by Universities.®

2015

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Articles 241 - 244 of 244

Full-Text Articles in Neuroscience and Neurobiology

Cyclic Gmp: A Satiety Signal In C. Elegans, Ji S. Park Jan 2015

Cyclic Gmp: A Satiety Signal In C. Elegans, Ji S. Park

Theses and Dissertations

Appetite control and satiety mechanisms help animals maintain energy homeostasis; however, these mechanisms can be misregulated, leading to overweight and obesity. Caenorhabditis elegans is an excellent model system to study appetite and satiety because of its conserved behavioral aspects of satiety and conserved molecular mechanisms. ASI senses nutrition and its activity is required for the behavioral state of satiety quiescence. The purpose of this thesis project was to elucidate the function of cGMP signaling in ASI by looking at behavioral effects from the pharmacological use of sildenafil (Viagra), a PDE inhibitor, and the effects on ASI activation from mutating guanylyl …

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Characterization Of The Trans-Plasma Membrane Electron Transport System In The Myelin Membrane, Afshan Sohail Jan 2015

Characterization Of The Trans-Plasma Membrane Electron Transport System In The Myelin Membrane, Afshan Sohail

Theses and Dissertations (Comprehensive)

Myelination is the key feature of evolution in the nervous system of vertebrates. Myelin is the protrusion of glial cells. More specifically, "oligodendrocytes" in the central nervous system (CNS), and "Schwann" cells in the peripheral nervous system (PNS) form myelin membranes. Myelin remarkably, enhances the propagation of nerve impulses. However, myelin restricts the access of extracellular metabolites to the axons. A pathology called "demyelination" is associated with myelin. The myelin sheath is not only an insulator, but it is itself metabolically active. In this study it is hypothesized that the ratio of NAD(P)+/NAD(P)H and the glycolytic pathway of …

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An Exploration Of The Wheel-Induced Feeding-Suppression, Stephen Benjamin Peckham Jan 2015

An Exploration Of The Wheel-Induced Feeding-Suppression, Stephen Benjamin Peckham

Theses and Dissertations (Comprehensive)

Anorexia nervosa is an enigmatic human condition typified by food-restriction that is often accompanied by extensive exercise. This has been modeled in rats in the wheel-induced feeding-suppression (WIFS) model. In this model, animals are given access to a running-wheel, which induces a volitional drop in food-consumption. Short periods of wheel access have induced a feeding-suppression which is effectively reversed by chlorpromazine administration (Adams et al., 2009). Recent attempts at replicating Adams et al.’s (2009) feeding-suppression have, however, been unsuccessful (Peckham et al., 2013). These attempts raised questions as to whether or not the existing methodology is most effective at suppressing …

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Influence Of Planning Resources On Gait Control In Parkinson’S Disease, Frederico P. Faria Jan 2015

Influence Of Planning Resources On Gait Control In Parkinson’S Disease, Frederico P. Faria

Theses and Dissertations (Comprehensive)

Movement disturbances in individuals with Parkinson’s disease (PD) have been associated with difficulties to plan complex actions. Performance of simple and complex actions overloads resources for individuals with Parkinson’s disease (PD). However, it is unclear if central resources required to plan gait adjustments while walking exacerbate gait disturbances of patients with PD. More specifically, it is unclear how gait impairments, sensory processing, and the dopaminergic system influence the load on processing resources (e.g. cognitive load) during the planning of step modifications. In order to investigate the relative influence of these factors on cognitive load and its impact on gait control, …

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