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Articles 31 - 58 of 58
Full-Text Articles in Neuroscience and Neurobiology
Analysis Of Candidate Genes For Seizure Susceptibility In Epileptogenesis, Brittany O'Brien
Analysis Of Candidate Genes For Seizure Susceptibility In Epileptogenesis, Brittany O'Brien
Legacy Theses & Dissertations (2009 - 2024)
The occurrence of recurrent spontaneous seizures is the hallmark of epilepsy. The key to understanding how a normal brain can develop epilepsy through a process known as epileptogenesis is identifying susceptibility factors. Previously, various strains of inbred mice from the hybrid mouse diversity panel were subjected to multiple seizures via the repeated flurothyl model (RFM) for epileptogenesis. The results demonstrated differences in kindling among the inbred strains; specifically two main trends in the generalized seizure threshold (GST) data were kindling-sensitive and kindling-resistant strains. In addition, genome wide association studies done from these mice demonstrated a quantitative trait locus (QTL) on …
Retinal Disease Modeling And Drug Screening Using Stem Cell Derived Retinal Pigment Epithelium, Janmeet Singh Saini
Retinal Disease Modeling And Drug Screening Using Stem Cell Derived Retinal Pigment Epithelium, Janmeet Singh Saini
Legacy Theses & Dissertations (2009 - 2024)
The eye is an intricate organ, possessing sensory receptors in the retina that are involved in visual perception. The retina consists primarily of the neural layer, referred to as the neural retina, and the pigmented layer, referred to as the retinal pigment epithelium (RPE). The neural retina and RPE develop and mature in a coordinated manner, and depend on each other for survival. In a mature healthy retina, the retinal photoreceptor outer segments interdigitate with the RPE monolayer, and they co-exchange key supportive factors. RPE cells are indispensable for the health of the retina as they are involved in a …
Harnessing Electrocorticographic Signals For Neuroscience And Neurosurgery, Adriana De Pesters
Harnessing Electrocorticographic Signals For Neuroscience And Neurosurgery, Adriana De Pesters
Legacy Theses & Dissertations (2009 - 2024)
Daily human activities, such as speaking, driving or listening to music, are produced by activations of neurons in the brain. Where, when and how these activations occur has been the subject of intense debate for the last decades. Traditional techniques to image the human brain, such as functional magnetic resonance imaging (fMRI) or electroencephalography (EEG), only provide limited information regarding where and when these activations take place. For that reason, critical information is currently missing regarding how neurons from different parts of the brain interact and coordinate their activity to implement behavior. This information is critical to understand human behavior …
Reduced Conscious Recollection And Its Detection In Three Performance Validity Tests : A Dual Task Interference Investigation, Graham Michael Silk-Eglit
Reduced Conscious Recollection And Its Detection In Three Performance Validity Tests : A Dual Task Interference Investigation, Graham Michael Silk-Eglit
Legacy Theses & Dissertations (2009 - 2024)
Performance validity is an essential component of neuropsychological assessment. Research suggests that examinees with specific neurological conditions cannot successfully complete certain performance validity tests (PVTs). However, very little basic research has explored the information processing underlying performance on PVTs that might explain why these examinees fail certain PVTs. The current study used a dual task interference paradigm to isolate the impact of reducing conscious recollection on the performance of three PVTs, the Test of Memory Malingering (TOMM), Victoria Symptom Validity Test (VSVT), and Word Memory Test (WMT). One-hundred-and-twenty-six non-clinical undergraduate research participants were administered these three PVTs as part of …
Separating The Signal From The Noise In Electrocorticographic (Ecog) Signals : Novel Analytic Methods And Their Application To Experimental And Theoretical Neuroscience, William Grey Coon
Separating The Signal From The Noise In Electrocorticographic (Ecog) Signals : Novel Analytic Methods And Their Application To Experimental And Theoretical Neuroscience, William Grey Coon
Legacy Theses & Dissertations (2009 - 2024)
Measurements are comprised of two parts: signal, that is, the true quantity one wishes to measure, and noise, that is, measurement fluctuations that are unrelated to the true signal.
A Novel Method For Studying Gene Regulatory Elements In Vivo Reveals Essential Roles For Intron Splicing In Neurofilament Gene Expression, Chen Wang
Legacy Theses & Dissertations (2009 - 2024)
Axon outgrowth requires coordinated expression of critical cytoskeletal genes in response to extracellular cues. The spatial and temporal expression of these genes is regulated transcriptionally and posttranscriptionally. Such regulation is largely mediated through the activity of cis-regulatory elements within the cytoskeletal DNAs and RNAs, which recruit specific sets of trans-factors such as DNA- and RNA-binding proteins, as well as microRNAs. To identify the functionally active cis-elements, characterize their dynamically changing sets of trans-factors, and investigate the association between the two sets of regulators in the context of an intact developing nervous system, one needs to combine appropriate in vivo strategies …
Spinal Transection Changes External Urethral Sphincter Muscle Activity And Motoneuron Properties : Implications For Lower Urinary Tract Function After Spinal Cord Injury, Brandon Keith Lapallo
Spinal Transection Changes External Urethral Sphincter Muscle Activity And Motoneuron Properties : Implications For Lower Urinary Tract Function After Spinal Cord Injury, Brandon Keith Lapallo
Legacy Theses & Dissertations (2009 - 2024)
Lower urinary tract (LUT) dysfunction is a major problem for people with spinal cord injury (SCI). SCI impairs the reciprocal coordination of the two main LUT functional components: the bladder, a storage reservoir for urine; and the external urethral sphincter muscle (EUS), which regulates the passage of urine through the urethra. This impairment frequently results in detrusor-sphincter dyssynergia (DSD), a dangerous condition in which involuntary EUS contraction prevents voiding of urine from the bladder. Despite the critical role of the EUS during normal function and in DSD, studies of the contribution of SCI-induced EUS motoneuron abnormalities to EUS and LUT …
Mediation Of Recurrent Hypoglycemia's Physiological And Behavioral Effects In The Hippocampus By Glucocorticoids, Danielle Osborne
Mediation Of Recurrent Hypoglycemia's Physiological And Behavioral Effects In The Hippocampus By Glucocorticoids, Danielle Osborne
Legacy Theses & Dissertations (2009 - 2024)
Recurrent hypoglycemia (RH) occurs with the over administration of insulin resulting in severe hypoglycemia on a repetitive basis. This occurs most commonly among Type I Diabetics who rely on exogenous insulin replacement for management of their disease; however it is becoming increasingly common among Type II Diabetics. Although cognitive deficits are reported during hypoglycemia, the period following restoration of euglycemia has been denoted by improved hippocampally-mediated short-term and working memory in humans and rodents, respectively. RH is also associated with an altered glucocorticoid secretion profile in response to hypoglycemia. In vitro and in vivo approaches were utilized with the goal …
The Postsynaptic Regulation Of Synaptic Strength In Drosophila, Daniel Michael Gertner
The Postsynaptic Regulation Of Synaptic Strength In Drosophila, Daniel Michael Gertner
Legacy Theses & Dissertations (2009 - 2024)
Postsynaptic Ca2+ plays an important role in synaptic homeostasis and synaptic plasticity. Postsynaptic Ca2+ signals have been shown to regulate synaptic transmission at the Drosophila larval neuromuscular junction (NMJ), however, these signals have not been well characterized. This will explore how these signals regulate synaptic strength and what channels are involved. In previous lab experiments Ca2+ transients were observed during evoked and spontaneous release (Desai and Lnenicka, 2011). It was further demonstrated that a reduction in synaptic strength occurs following synaptic stimulation. It was hypothesized that the increase in postsynaptic Ca2+ following synaptic stimulation activates the gCS and causes a …
Structure-Activity Relationship Of 2,3-Benzodiazepin-4-Ones As Noncompetitive Ampa Receptor Antagonists, Mohammad Shaban Qneibi
Structure-Activity Relationship Of 2,3-Benzodiazepin-4-Ones As Noncompetitive Ampa Receptor Antagonists, Mohammad Shaban Qneibi
Legacy Theses & Dissertations (2009 - 2024)
2,3-Benzodiazepin-4-one (BDZ-11) derivatives are a special group of 2,3-benzodiazepine compounds. These compounds have been previously synthesized as AMPA receptor inhibitors, and they are also potential drugs for the treatment of various neurological diseases involving excessive AMPA receptor activity. AMPA receptors are a subtype of glutamate ion channel proteins and are responsible for the majority of excitatory neurotransmission in the mammalian central nervous system. Specifically, they are critically involved in neuronal development and brain activities, including learning and memory. Overstimulation of AMPA receptors is associated with some neurological diseases such as ALS, stroke and Alzheimer's disease. Despite the fact that hundreds …
Post-Translational Modification Regulates Heterogeneous Nuclear Ribonucleoprotein K Function During Axon Outgrowth In Xenopus Laevis, Erica J. Hutchins
Post-Translational Modification Regulates Heterogeneous Nuclear Ribonucleoprotein K Function During Axon Outgrowth In Xenopus Laevis, Erica J. Hutchins
Legacy Theses & Dissertations (2009 - 2024)
The RNA-binding protein, heterogeneous nuclear ribonucleoprotein K (hnRNP K), is required for axon outgrowth. Its suppression in Xenopus embryos causes defects in the translation of mRNAs of multiple cytoskeletal genes. Studies in cell lines have established that hnRNP K shuttles between the nucleus and the cytoplasm to bind and regulate the fates of its target RNAs, from splicing to export and translation. At each step, hnRNP K is regulated through post-translational modifications that alter its nucleic acid and protein interactions, and subcellular localization. Precisely how this happens in developing neurons to coordinate cytoskeletal gene expression with the extracellular signals directing …
Btbr-Fvb Chromosome 4 Congenic Displays Rescue Of Behavior And Neuro-Anatomical Phenotypes, Jessica F. Gracias
Btbr-Fvb Chromosome 4 Congenic Displays Rescue Of Behavior And Neuro-Anatomical Phenotypes, Jessica F. Gracias
Legacy Theses & Dissertations (2009 - 2024)
Autism is commonly called the most genetic of neuropsychiatric disorders. Currently, the only diagnostic test is a behavioral evaluation performed by trained physicians and psychologists. There is an urgent need for biomarkers to diagnose autism instead of just relying on behavior and there is also a need to understand the basis of this disorder. One of the theories is that malformation of the corpus callosum is one of the factors that lead to the behavior deficits seen in autism. This theory is based on the fact that human MRI studies have shown that the corpus callosum is absent or malformed …
Functional Roles Of The Insulin-Regulated Glucose Transporter-4 In The Hippocampus, Jiah Pearson-Leary
Functional Roles Of The Insulin-Regulated Glucose Transporter-4 In The Hippocampus, Jiah Pearson-Leary
Legacy Theses & Dissertations (2009 - 2024)
Although a great deal of research has elucidated both localization and function of many glucose transporters (GluTs) throughout the brain, the function of brain insulin-responsive glucose transporter-4 (GluT4) remains unclear (McEwen & Reagan, 2004). Because type 2 diabetes mellitus (T2DM; insulin resistance, i.e., impaired insulin signaling) is a risk factor for Alzheimer's disease (AD), and because the signaling mechanisms insulin uses to mediate hippocampal processes and memory are unclear, a major purpose of this dissertation was to determine whether hippocampal GluT4, which is responsible for insulin's glucoregulatory and canonical effects in the periphery, is necessary for insulin's effects in the …
The Role Of Progesterone Receptor In The Development Of The Mesocortical Dopaminergic Pathway, Jari Willing
The Role Of Progesterone Receptor In The Development Of The Mesocortical Dopaminergic Pathway, Jari Willing
Legacy Theses & Dissertations (2009 - 2024)
The mesocortical dopaminergic pathway, comprised of projections from the ventral tegmental area (VTA) to the prefrontal cortex (PFC), mediates many of the most complex forms of cognitive behaviors and has been associated with clinical disorders such as ADHD and schizophrenia. While this circuit continues to develop throughout much of the lifespan, there is a rapid period of maturation, early in development, in which this circuit is highly sensitive to disruption. Steroid hormone receptors are powerful transcription factors, capable of affecting a variety of neurodevelopmental processes and are expressed in many regions throughout the developing brain. Specifically, the nuclear progesterone receptor …
Expression Of Suppressor Of Cytokine Signaling 2 (Socs2) During Optic Nerve Regeneration In Xenopus Laevis, Rupa Priscilla Choudhary
Expression Of Suppressor Of Cytokine Signaling 2 (Socs2) During Optic Nerve Regeneration In Xenopus Laevis, Rupa Priscilla Choudhary
Legacy Theses & Dissertations (2009 - 2024)
The optic nerve and other central nervous system (CNS) axons tend to lose their capacity to regenerate following an injury in adult amniotes, but these axons are able to regenerate throughout life in anamniotes. The long-term goal of my study is to identify molecular mechanisms responsible for the retention of this regenerative capacity. Specifically, I will examine the role of the gene Suppressor of Cytokine Signaling 2 (SOCS2) in the successful regeneration of retinal ganglion cell (RGC) axons of the South African claw-toed frog, Xenopus laevis, after injury.
Spatial Working Memory And Adult Hippocampal Neurogenesis In Male Rats With Hight Fat Diet-Induced Obesity, Andrew Karl Recknagel
Spatial Working Memory And Adult Hippocampal Neurogenesis In Male Rats With Hight Fat Diet-Induced Obesity, Andrew Karl Recknagel
Legacy Theses & Dissertations (2009 - 2024)
Granule cells are continually produced in the dentate gyrus of the hippocampus throughout life. These new neurons integrate into the local circuitry and contribute to hippocampal function. Insulin directly affects hippocampal function and may also influence the process of adult neurogenesis. Some of the cognitive deficits that occur in Type 2 Diabetes Mellitus (T2DM) and Alzheimer's disease (AD) may be caused by hyperinsulinemia and systemic insulin resistance. Sedentary lifestyles combined with over-consumption of energy rich foods are responsible for the rising incidence of metabolic syndrome and chronic obesity, both of which represent major risk factors for T2DM and AD. Therefore, …
Identification Of Trophic And Transcriptional Requirements For Human Embryonic Stem Cell Culture And Guided Neural Differentiation, Nicolas Edward Tokas
Identification Of Trophic And Transcriptional Requirements For Human Embryonic Stem Cell Culture And Guided Neural Differentiation, Nicolas Edward Tokas
Legacy Theses & Dissertations (2009 - 2024)
Translational biomedical research holds potential for the development of novel therapeutics for the treatment of injury, illness or disability. To better understand intrinsic cellular and molecular biology, human embryonic stem cells (hESCs) can be used as a tool. hESCs are pluripotent with the abilities to be held in a self-renewal state or become induced to a desired germ layer then to be later directed through differentiation.
Mechanism Of Inhibition Of The Glua2 Receptors By N-3 Derivatives Of 2,3-Benzodiazepines With C-4 Methyl Group, Congzhou Wang
Mechanism Of Inhibition Of The Glua2 Receptors By N-3 Derivatives Of 2,3-Benzodiazepines With C-4 Methyl Group, Congzhou Wang
Legacy Theses & Dissertations (2009 - 2024)
α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are one of the three subtypes of ionotropic glutamate receptors. AMPA receptors mediate fast synaptic neurotransmission in the central nervous system (CNS). Over-activation of calcium permeable AMPA receptors causes intracellular calcium overload, which leads to neurodegeneration and cell death. As such, AMPA receptors have been implicated in a number of neurological disorders and diseases, such as epilepsy, amyotrophic lateral sclerosis (ALS), and Parkinson's disease. 2,3-Benzodiazepine derivatives (or GYKI compounds) are a group of structurally similar compounds synthesized as inhibitors of AMPA receptors, and they have been used as potential drug candidates for the treatment of various …
The Role Of An Rna Binding Protein Hnrnp K During Axon Development And Regeneration In Xenopus Laevis, Yuanyuan Liu
The Role Of An Rna Binding Protein Hnrnp K During Axon Development And Regeneration In Xenopus Laevis, Yuanyuan Liu
Legacy Theses & Dissertations (2009 - 2024)
Coordinated synthesis and assembly of the cytoskeletal network contribute significantly to morphological changes during axon outgrowth. Previous studies demonstrated that heterogeneous ribonucleoprotein K (hnRNP K), an RNA binding protein, binds to the 3'-untranslated regions of all neurofilament triplet subunits, the most abundant components of the axonal cytoskeleton. These findings raised the hypothesis that hnRNP K post-transcriptionally mediates the coordinated expression of axonal cytoskeletal components. In my thesis, I test this hypothesis during both axonal development and regeneration.
Characterization Of Postsynaptic Calcium(Ii) Signals And Their Role In Synaptic Regulation At The Drosophila Larval Neuromuscular Junction, Sunil Ashok Desai
Characterization Of Postsynaptic Calcium(Ii) Signals And Their Role In Synaptic Regulation At The Drosophila Larval Neuromuscular Junction, Sunil Ashok Desai
Legacy Theses & Dissertations (2009 - 2024)
Postsynaptic [Ca2+]i has been proposed to play an important role in both synaptic plasticity and synaptic homeostasis. Postsynaptic Ca2+ signals appear to regulate synaptic transmission at the Drosophila larval NMJ; however, they have not been characterized at a NMJ. We were interested in examining the postsynaptic Ca2+ signals in this system and determining its influence on synaptic strength. The muscle Ca2+ transients were recorded by injecting the muscle fibers with Ca2+ indicators; discrete postsynaptic Ca2+ transients were observed along the NMJ during evoked and spontaneous transmitter release. The magnitude of the Ca2+ signals was correlated with synaptic efficacy, terminals producing …
Cortical-Spinal Interactions In Skill Acquisition And Performance And Their Implications For Rehabilitation, Chadwick Bruno Jean Boulay
Cortical-Spinal Interactions In Skill Acquisition And Performance And Their Implications For Rehabilitation, Chadwick Bruno Jean Boulay
Legacy Theses & Dissertations (2009 - 2024)
Many people in the United States have motor impairments due to stroke or other central nervous system (CNS) traumas. Motor impairments also burden the U.S. economy and health care system. Current rehabilitative therapies are moderately effective but can be improved upon. Improvements to rehabilitation protocols are informed by increased understanding of the CNS including understanding interactions between different structures in the CNS and understanding CNS plasticity in response to trauma or skill acquisition.
The Formation And Distribution Of Hippocampal Synapses On Patterned Neuronal Networks, Natalie Michelle Dowell-Mesfin
The Formation And Distribution Of Hippocampal Synapses On Patterned Neuronal Networks, Natalie Michelle Dowell-Mesfin
Legacy Theses & Dissertations (2009 - 2024)
ABSTRACT
Calcium Regulation And Transmitter Release At Drosophila Larval Neuromuscular Junction, Tao He
Calcium Regulation And Transmitter Release At Drosophila Larval Neuromuscular Junction, Tao He
Legacy Theses & Dissertations (2009 - 2024)
Calcium ions act as the most versatile 2nd messenger and are involved in an incredibly broad spectrum of biological processes. Proper cellular Ca2+ homeostasis is paramount in maintaining normal cell growth, functions, survival and programmed death. Hence, understanding Ca2+ regulation has been a goal of and a hot topic in cutting-edge biological research for decades. Recently, the advent of a new generation of Ca2+ indicators has made a major contribution to advances in understanding Ca2+ regulation (Grynkiewicz et al., 1985). Likewise, the application of Drosophila melanogaster as an animal model has provided tantalizing clues and fueled the progress of research …
The Role Of Androstane Neurosteroids In Alcohol-Mediated Social Behavior, Jason J. Paris
The Role Of Androstane Neurosteroids In Alcohol-Mediated Social Behavior, Jason J. Paris
Legacy Theses & Dissertations (2009 - 2024)
Androgenic steroids, such as testosterone, may influence the propensity for aggression in both people and animals. Some of testosterone's effects on aggression may be due, in part, to its metabolic products that are 5á-reduced and 3á-hydroxylated to form, 3á-androstanediol (3á-diol), which can also enhance aggression in mice. Notably, alcohol (EtOH) consumption facilitates aggression in people and animals, particularly among those predisposed to act aggressively. In rats, EtOH can increase 3á-diol in prefrontal cortex, which may facilitate aggression. The present work aimed to elucidate the role of 3á-diol for EtOH-enhanced aggression. We hypothesized that EtOH would enhance inter-male aggression, social dominance, …
A Functional Study Of Ampa And Kainate Receptors, Yan Han
A Functional Study Of Ampa And Kainate Receptors, Yan Han
Legacy Theses & Dissertations (2009 - 2024)
The ionotropic glutamate receptors are localized in the pre- and postsynaptic membrane of neurons and mediate the majority of fast excitatory synaptic transmission. These receptors are divided into three subtypes: α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainic acid, and N-methyl-D-aspartic acid (NMDA) receptors. My thesis work focused on AMPA and kainate receptor subtypes.
Physiology Of Yawning : Proximate Mechanisms Supporting An Ultimate Function, Melanie Lee Shoup-Knox
Physiology Of Yawning : Proximate Mechanisms Supporting An Ultimate Function, Melanie Lee Shoup-Knox
Legacy Theses & Dissertations (2009 - 2024)
Recent research suggests that yawning functions to cool the brain during periods of mild hyperthermia. Evidence for this hypothesis is largely behavioral, and includes reports of increased yawning during increases in ambient temperature and times of stress as well as an amelioration of yawning upon nasal breathing and forehead cooling. Little research has been published on the physiological mechanisms supporting a brain cooling function, however. The current set of studies explores human and animal physiological parameters in search of evidence of brain cooling during yawning. In humans, heart rate, skin temperature, and skin conductance findings suggest that yawning involves an …
Three-Dimensional Hydrogel Cell Culture Systems For Modeling Neural Tissue, John P. Frampton
Three-Dimensional Hydrogel Cell Culture Systems For Modeling Neural Tissue, John P. Frampton
Legacy Theses & Dissertations (2009 - 2024)
Two-dimensional (2-D) neural cell culture systems have served as physiological models for understanding the cellular and molecular events that underlie responses to physical and chemical stimuli, control sensory and motor function, and lead to the development of neurological diseases. However, the development of three-dimensional (3-D) cell culture systems will be essential for the advancement of experimental research in a variety of fields including tissue engineering, chemical transport and delivery, cell growth, and cell-cell communication. In 3-D cell culture, cells are provided with an environment similar to tissue, in which they are surrounded on all sides by other cells, structural molecules …
Anatomical Substrates Of Central Nervous System Plasticity Induced By Spinal Cord Reflex Conditioning And Sensorimotor Cortex Stimulation, Shreejith Pillai
Anatomical Substrates Of Central Nervous System Plasticity Induced By Spinal Cord Reflex Conditioning And Sensorimotor Cortex Stimulation, Shreejith Pillai
Legacy Theses & Dissertations (2009 - 2024)
ABSTRACT