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University of Nevada, Las Vegas

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Articles 151 - 152 of 152

Full-Text Articles in Neuroscience and Neurobiology

Neurocognitive Deficits And Functional Outcome In Bipolar Disorder, Danielle T. Bello Jan 2009

Neurocognitive Deficits And Functional Outcome In Bipolar Disorder, Danielle T. Bello

UNLV Theses, Dissertations, Professional Papers, and Capstones

Bipolar disorder affects approximately 1% of the population. It is a severe and debilitating illness, causing serious impairment of interpersonal, occupational and social functioning. The disorder is characterized by marked mood swings as well significant neurocognitive deficits. Based on work with other psychiatric and neurological disorders, neurocognitive deficits in bipolar disorder are expected to be strong predictors of functional capacity. However, few studies have evaluated the consequences of neurocognitive deficits in this disorder. Most available studies have focused on the clinical correlates of functional outcome, such as number of hospitalizations, age of disorder onset, and severity of symptoms. While useful, …

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Induction Of Integral Membrane Pam Expression In Att-20 Cells Alters The Storage And Trafficking Of Pomc And Pc1, Giuseppe D. Ciccotosto, Martin R. Schiller, Betty A. Eipper, Richard E. Mains Feb 1999

Induction Of Integral Membrane Pam Expression In Att-20 Cells Alters The Storage And Trafficking Of Pomc And Pc1, Giuseppe D. Ciccotosto, Martin R. Schiller, Betty A. Eipper, Richard E. Mains

Life Sciences Faculty Research

Peptidylglycine alpha-amidating monooxygenase (PAM) is an essential enzyme that catalyzes the COOH-terminal amidation of many neuroendocrine peptides. The bifunctional PAM protein contains an NH2-terminal monooxygenase (PHM) domain followed by a lyase (PAL) domain and a transmembrane domain. The cytosolic tail of PAM interacts with proteins that can affect cytoskeletal organization. A reverse tetracycline-regulated inducible expression system was used to construct an AtT-20 corticotrope cell line capable of inducible PAM-1 expression. Upon induction, cells displayed a time- and dose-dependent increase in enzyme activity, PAM mRNA, and protein. Induction of increased PAM-1 expression produced graded changes in PAM-1 metabolism. Increased expression of …

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