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Articles 91 - 120 of 152
Full-Text Articles in Neuroscience and Neurobiology
Voxel-Based Morphometry Reveals Brain Gray Matter Volume Changes In Successful Dieters, Robyn A. Honea, Amanda N. Szabo-Reed, Rebecca J. Lepping, Rodrigo Perea, Florence Breslin, Laura E. Martin, William M. Brooks, Joseph E. Donnelly, Cary R. Savage
Voxel-Based Morphometry Reveals Brain Gray Matter Volume Changes In Successful Dieters, Robyn A. Honea, Amanda N. Szabo-Reed, Rebecca J. Lepping, Rodrigo Perea, Florence Breslin, Laura E. Martin, William M. Brooks, Joseph E. Donnelly, Cary R. Savage
Center for Brain, Biology, and Behavior: Faculty Publications
Objective: To compare regional brain volume predictors of percent weight loss (WL) in dieters with obesity (DwO) and in the same participants categorized as “successful” (≥7% WL) or “unsuccessful” dieters (
Perceived Threat Associated With Police Officers And Black Men Predicts Support For Policing Policy Reform, Allison L. Skinner, Ingrid J. Haas
Perceived Threat Associated With Police Officers And Black Men Predicts Support For Policing Policy Reform, Allison L. Skinner, Ingrid J. Haas
Center for Brain, Biology, and Behavior: Faculty Publications
Racial disparities in policing and recent high-profile incidents resulting in the deaths of Black men have ignited a national debate on policing policies. Given evidence that both police officers and Black men may be associated with threat, we examined the impact of perceived threat on support for reformed policing policies. Across three studies we found correlational evidence that perceiving police officers as threatening predicts increased support for reformed policing practices (e.g., limiting the use of lethal force and matching police force demographics to those of the community). In contrast, perceiving Black men as threatening predicted reduced support for policing policy …
Analysis Of Neuronal Sequences Using Pairwise Biases, Zachary Roth
Analysis Of Neuronal Sequences Using Pairwise Biases, Zachary Roth
Department of Mathematics: Dissertations, Theses, and Student Research
Sequences of neuronal activation have long been implicated in a variety of brain functions. In particular, these sequences have been tied to memory formation and spatial navigation in the hippocampus, a region of mammalian brains. Traditionally, neuronal sequences have been interpreted as noisy manifestations of neuronal templates (i.e., orderings), ignoring much richer structure contained in the sequences. This paper introduces a new tool for understanding neuronal sequences: the bias matrix. The bias matrix captures the probabilistic tendency of each neuron to fire before or after each other neuron. Despite considering only pairs of neurons, the bias matrix captures the best …
Investigating The Influences Of Language Delay And/Or Familial Risk For Dyslexia On Brain Structure In 5-Year-Olds, Nora Maria Raschle, Bryce Larkin Chessell Becker, Sara Smith, Lynn Valérie Fehlbaum, Yingying Wang, Nadine Gaab
Investigating The Influences Of Language Delay And/Or Familial Risk For Dyslexia On Brain Structure In 5-Year-Olds, Nora Maria Raschle, Bryce Larkin Chessell Becker, Sara Smith, Lynn Valérie Fehlbaum, Yingying Wang, Nadine Gaab
Center for Brain, Biology, and Behavior: Faculty Publications
Early language delay has often been associated with atypical language/literacy development. Neuroimaging studies further indicate functional disruptions during language and print processing in school-age children with a retrospective report of early language delay. Behavioral data of 114 5-year-olds with a retrospective report of early language delay in infancy (N = 34) and those without (N = 80) and with a familial risk for dyslexia and those without are presented. Behaviorally, children with a retrospective report of early language delay exhibited reduced performance in language/reading-related measures. A voxel-based morphometry analysis in a subset (N = 46) demonstrated an association between reduced …
Involvement Of The Right Hemisphere In Reading Comprehension: A Dti Study, Tzipi Horowitz-Kraus, Yingying Wang, Elena Plante, Scott K. Holland
Involvement Of The Right Hemisphere In Reading Comprehension: A Dti Study, Tzipi Horowitz-Kraus, Yingying Wang, Elena Plante, Scott K. Holland
Center for Brain, Biology, and Behavior: Faculty Publications
The Simple View of reading emphasizes the critical role of two factors in normal reading skills: word recognition and reading comprehension. The current study aims to identify the anatomical support for aspects of reading performance that fall within these two components. Fractional anisotropy (FA) values were obtained from Diffusion Tensor images in twenty-one typical adolescents and young adults using the Tract Based Spatial Statistics (TBSS) method. We focused on the Arcuate Fasciculus (AF) and Inferior Longitudinal Fasciculus (ILF) as fiber tracts that connect regions already implicated in the distributed cortical network for reading. Our results demonstrate dissociation between word-level and …
Increased Resting-State Functional Connectivity Of Visual- And Cognitive-Control Brain Networks After Training In Children With Reading Difficulties, Tzipi Horowitz-Kraus, Mark Difrancesco, Benjamin Kay, Yingying Wang, Scott K. Holland
Increased Resting-State Functional Connectivity Of Visual- And Cognitive-Control Brain Networks After Training In Children With Reading Difficulties, Tzipi Horowitz-Kraus, Mark Difrancesco, Benjamin Kay, Yingying Wang, Scott K. Holland
Center for Brain, Biology, and Behavior: Faculty Publications
The Reading Acceleration Program, a computerized reading-training program, increases activation in neural circuits related to reading.We examined the effect of the training on the functional connectivity between independent components related to visual processing, executive functions, attention, memory, and language during rest after the training. Children 8–12 years old with reading difficulties and typical readers participated in the study. Behavioral testing and functional magnetic resonance imaging were performed before and after the training. Imaging data were analyzed using an independent component analysis approach. After training, both reading groups showed increased single-word contextual reading and reading comprehension scores. Greater positive correlations between …
Physical Feature Encoding And Word Recognition Abilities Are Altered In Children With Intractable Epilepsy: Preliminary Neuromagnetic Evidence, Maria Pardos, Milena Korostenskaja, Jing Xiang, Hisako Fujiwara, Ki H. Lee, Paul S. Horn, Anna Byars, Jennifer Vannest, Yingying Wang, Nat Hemasilpin, Douglas F. Rose
Physical Feature Encoding And Word Recognition Abilities Are Altered In Children With Intractable Epilepsy: Preliminary Neuromagnetic Evidence, Maria Pardos, Milena Korostenskaja, Jing Xiang, Hisako Fujiwara, Ki H. Lee, Paul S. Horn, Anna Byars, Jennifer Vannest, Yingying Wang, Nat Hemasilpin, Douglas F. Rose
Center for Brain, Biology, and Behavior: Faculty Publications
Objective evaluation of language function is critical for children with intractable epilepsy under consideration for epilepsy surgery. The purpose of this preliminary study was to evaluate word recognition in children with intractable epilepsy by using magnetoencephalography (MEG). Ten children with intractable epilepsy (M/F 6/4, mean ± SD 13.4 ± 2.2 years) were matched on age and sex to healthy controls. Common nouns were presented simultaneously from visual and auditory sensory inputs in “match” and “mismatch” conditions. Neuromagnetic responses M1, M2, M3, M4, and M5 with latencies of ∼100ms, ∼150ms, ∼250ms, ∼350ms, and ∼450ms, respectively, elicited during the “match” condition were …
An Exploratory High-Density Eeg Investigation Of The Misinformation Effect: Attentional And Recollective Differences Between True And False Perceptual Memories, John E. Kiat, Robert F. Belli
An Exploratory High-Density Eeg Investigation Of The Misinformation Effect: Attentional And Recollective Differences Between True And False Perceptual Memories, John E. Kiat, Robert F. Belli
Department of Psychology: Faculty Publications
The misinformation effect, a phenomenon in which eyewitness memories are altered via exposure to post-event misinformation, is one of the most important paradigms used to investigate the reconstructive nature of human memory. The aim of this study was to use the misinformation effect paradigm to investigate differences in attentional and recollective processing between true and false event memories. Nineteen participants completed a variant of the misinformation paradigm in which recognition responses to true and misinformation based event details embedded within a narrative context, were investigated using high-density (256-channel) EEG with a 1-day delay between event exposure and test. Source monitoring …
Spatial And Temporal Characteristics Of Error-Related Activity In The Human Brain, Maital Neta, Francis M. Miezin, Steven M. Nelson, Joseph W. Dubis, Nico U.F. Dosenbach, Bradley L. Schlaggar, Steven E. Petersen
Spatial And Temporal Characteristics Of Error-Related Activity In The Human Brain, Maital Neta, Francis M. Miezin, Steven M. Nelson, Joseph W. Dubis, Nico U.F. Dosenbach, Bradley L. Schlaggar, Steven E. Petersen
Center for Brain, Biology, and Behavior: Faculty Publications
A number of studies have focused on the role of specific brain regions, such as the dorsal anterior cingulate cortex during trials on which participants make errors, whereas others have implicated a host of more widely distributed regions in the human brain. Previous work has proposed that there are multiple cognitive control networks, raising the question of whether error-related activity can be found in each of these networks. Thus, to examine error-related activity broadly, we conducted a meta-analysis consisting of 12 tasks that included both error and correct trials. These tasks varied by stimulus input (visual, auditory), response output (button …
The Need For Theory To Guide Concussion Research, Dennis Molfese
The Need For Theory To Guide Concussion Research, Dennis Molfese
Center for Brain, Biology, and Behavior: Faculty Publications
While the focus on concussion research has expanded greatly over the past decade, progress in identifying the mechanisms and consequences of head injury, the recovery path and the development of potential interventions to facilitate recovery have been largely absent. Instead, the field has largely progressed through an accumulation of data without the guidance of any systematic theory to guide the formulation of research questions or generate testable hypotheses. As part of this special issue on sports concussion, we advance a theory to describe the evolution of a neural network during the development of a cognitive process as well as the …
Resting-State Brain Connectivity After Surgical And Behavioral Weight Loss, Rebecca J. Lepping, Amanda S. Bruce, Alex Francisco, Hung-Wen Yeh, Laura E. Martin, Joshua N. Powell, Laura Hancock, Trisha M. Patrician, Florence J. Breslin, Niazy Selim, Joseph E. Donnelly, William M. Brooks, Cary R. Savage, W. Kyle Simmons, Jared M. Bruce
Resting-State Brain Connectivity After Surgical And Behavioral Weight Loss, Rebecca J. Lepping, Amanda S. Bruce, Alex Francisco, Hung-Wen Yeh, Laura E. Martin, Joshua N. Powell, Laura Hancock, Trisha M. Patrician, Florence J. Breslin, Niazy Selim, Joseph E. Donnelly, William M. Brooks, Cary R. Savage, W. Kyle Simmons, Jared M. Bruce
Center for Brain, Biology, and Behavior: Faculty Publications
Objective: Changes in food-cue neural reactivity associated with behavioral and surgical weight loss interventions have been reported. Resting functional connectivity represents tonic neural activity that may contribute to weight loss success. This study explores whether intervention type is associated with differences in functional connectivity after weight loss. Methods: Fifteen participants with obesity were recruited prior to adjustable gastric banding surgery. Thirteen demographically matched participants with obesity were selected from a separate behavioral diet intervention. Resting-state functional magnetic resonance imaging was collected 3 months after surgery/ behavioral intervention. ANOVA was used to examine post-weight loss differences between the two groups in …
Differences In Prefrontal Cortex Activation And Deactivation During Strategic Episodic Verbal Memory Encoding In Mild Cognitive Impairment, Joana B. Balardin, Marcelo C. Batistuzzo, Maria Da Graca Moraes Martin, Joao R. Sato, Jerusa Smid, Claudia Porto, Cary R. Savage, Ricardo Nitrini, Edson Amaro Jr., Eliane C. Miotto
Differences In Prefrontal Cortex Activation And Deactivation During Strategic Episodic Verbal Memory Encoding In Mild Cognitive Impairment, Joana B. Balardin, Marcelo C. Batistuzzo, Maria Da Graca Moraes Martin, Joao R. Sato, Jerusa Smid, Claudia Porto, Cary R. Savage, Ricardo Nitrini, Edson Amaro Jr., Eliane C. Miotto
Center for Brain, Biology, and Behavior: Faculty Publications
In this study we examined differences in fMRI activation and deactivation patterns during episodic verbal memory encoding between individuals with MCI (n = 18) and healthy controls (HCs) (n = 17). Participants were scanned in two different sessions during the application of self-initiated or directed instructions to apply semantic strategies at encoding of word lists. MCI participants showed reduced free recall scores when using self-initiated encoding strategies that were increased to baseline controls' level after directed instructions were provided. During directed strategic encoding, greater recruitment of frontoparietal regions was observed in both MCI and control groups; group differences …
Clique Topology Reveals Intrinsic Geometric Structure In Neural Correlations, Chad Giusti, Eva Pastalkova, Carina Curto, Vladimir Itskov
Clique Topology Reveals Intrinsic Geometric Structure In Neural Correlations, Chad Giusti, Eva Pastalkova, Carina Curto, Vladimir Itskov
Department of Mathematics: Faculty Publications
Detecting meaningful structure in neural activity and connectivity data is challenging in the presence of hidden nonlinearities, where traditional eigenvalue-based methods may be misleading. We introduce a novel approach to matrix analysis, called clique topology, that extracts features of the data invariant under nonlinear monotone transformations. These features can be used to detect both random and geometric structure, and depend only on the relative ordering of matrix entries. We then analyzed the activity of pyramidal neurons in rat hippocampus, recorded while the animal was exploring a 2D environment, and confirmed that our method is able to detect geometric organization using …
White Matter Differences Between Multiple System Atrophy (Parkinsonian Type) And Parkinson’S Disease: A Diffusion Tensor Image Study, L. Ji, Yingying Wang, Nanjing Medical University, J. Shi
White Matter Differences Between Multiple System Atrophy (Parkinsonian Type) And Parkinson’S Disease: A Diffusion Tensor Image Study, L. Ji, Yingying Wang, Nanjing Medical University, J. Shi
Department of Special Education and Communication Disorders: Faculty Publications
The clinical differential diagnosis between the Parkinson variant of multiple system atrophy (MSA-P) and Parkinson’s disease (PD) is difficult in early stages. To identify objective markers for differential diagnosis, we combined the novel tract-based spatial statistics (TBSS) and region of interest (ROI) analyses for the first time to investigate three groups (15 MSA-P, 20 PD patients and 20 controls) with diffusion tensor imaging data. By TBSS, we performed pairwise comparisons of fractional anisotropy (FA), mean diffusivity, radial diffusivity (RD) and axial diffusivity maps. The clusters with significant differences between MSA-P and PD were used as ROIs for further analyses. FA/RD …
A Quantitative Analysis Of The Value-Enhancing Effects Of Nicotine, Bupropion, And Varenicline In Male And Female Rats, Scott Barrett
A Quantitative Analysis Of The Value-Enhancing Effects Of Nicotine, Bupropion, And Varenicline In Male And Female Rats, Scott Barrett
Department of Psychology: Dissertations, Theses, and Student Research
Smoking and tobacco dependence are serious health concerns in the United States and globally. Reward via the pharmacological effects of nicotine are believed to be the principal motivating factor that drive tobacco dependence. Research reveals differences in sensitivity between males and females to the motivational effects of nicotine in tobacco use. Enhancement of reinforcement value of non-nicotine rewards contributes to overall nicotine reward. Similar value-enhancing effects have been observed by the two most commonly prescribed smoking cessation aids, bupropion and varenicline. The present dissertation investigated the value-enhancing effects of nicotine, bupropion and varenicline in both male and female rats using …
Asenapine Sensitization From Adolescence To Adulthood And Its Potential Molecular Basis, Qing Shu, Rongyin Qin, Yingzhu Chen, Gang Hu, Ming Li
Asenapine Sensitization From Adolescence To Adulthood And Its Potential Molecular Basis, Qing Shu, Rongyin Qin, Yingzhu Chen, Gang Hu, Ming Li
Department of Psychology: Faculty Publications
Asenapine is a new antipsychotic drug that induces a long-lasting behavioral sensitization in adult rats. The present study investigated the developmental impacts of adolescent asenapine treatment on drug sensitivity and on 3 proteins implicated in the action of antipsychotic drugs (i.e. Brainderived neurotrophic factor (BDNF), dopamine D2 receptor, and ΔFosB) in adulthood. Male adolescent Sprague-Dawley rats (postnatal days, P 43-48) were first treated with asenapine (0.05, 0.10 or 0.20 mg/kg, sc) and tested in the conditioned avoidance or PCP (2.0 mg/kg, sc)-induced hyperlocomotion tasks for 5 days. After they became adults (∼P 76), asenapine sensitization was assessed in a …
Effect Of Environmental Cues On Behavioral Efficacy Of Haloperidol, Olanzapine And Clozapine In Rats, Tao Sun, Xinfeng Liu, Ming Li
Effect Of Environmental Cues On Behavioral Efficacy Of Haloperidol, Olanzapine And Clozapine In Rats, Tao Sun, Xinfeng Liu, Ming Li
Department of Psychology: Faculty Publications
Previous studies have reported that context can powerfully modulate the inhibitory effect of an antipsychotic drug on phencyclidine (PCP)-induced hyperlocomotion (a behavioral test used to evaluate putative antipsychotic drugs). The present study investigated the experimental conditions under which environmental stimuli exert their influence through associative conditioning processes. Experiment 1 examined the extent to which prior antipsychotic treatment in the home cages affected a drug’s ability to inhibit PCP-induced hyperlocomotion in a novel motor activity test apparatus. Five days of repeated haloperidol (0.05 mg/kg, sc) and olanzapine (2.0 mg/kg, sc) treatment in the home cages still potentiated their inhibition of PCP-induced …
Brain Science And Stem Learning, Dennis L. Molfese
Brain Science And Stem Learning, Dennis L. Molfese
Discipline-Based Education Research Group Speaker Series
Brain Science is an interdisciplinary science and as such touches on a host of domains that among others include Behavioral & Social Sciences, Biological Sciences, Computer & Information Science, Economics, Engineering (multiple domains from Electrical to Mechanical to Structural), Education, Human Resources, Engineering, Environmental, Education, Geosciences, Engineering, Mathematical, Physical Sciences, Psychology, and Zoology. The approach provides a means to study matter from an assortment of elements to the integration of complex domains that stretch from the interactions of neuropeptides to conscious thought that cover the lifespan of single cell organisms to humans. We will touch on a few of these …
Comparison Of Functional Network Connectivity For Passive-Listening And Active-Response Narrative Comprehension In Adolescents, Yingying Wang, Scott K. Holland
Comparison Of Functional Network Connectivity For Passive-Listening And Active-Response Narrative Comprehension In Adolescents, Yingying Wang, Scott K. Holland
Center for Brain, Biology, and Behavior: Faculty Publications
Comprehension of narrative stories plays an important role in the development of language skills. In this study, we compared brain activity elicited by a passive-listening version and an active-response (AR) version of a narrative comprehension task by using independent component (IC) analysis on functional magnetic resonance imaging data from 21 adolescents (ages 14–18 years). Furthermore, we explored differences in functional network connectivity engaged by two versions of the task and investigated the relationship between the online response time and the strength of connectivity between each pair of ICs. Despite similar brain region involvements in auditory, temporoparietal, and frontoparietal language networks …
Effects Of 5-Hydroxytryptamine 2c Receptor Agonist Mk212 And 2a Receptor Antagonist Mdl100907 On Maternal Behavior In Postpartum Female Rats, Weihai Chen, Qi Zhang, Wenxin Su, Yu Yang, Jing Qiao, Nan Sui, Ming Li
Effects Of 5-Hydroxytryptamine 2c Receptor Agonist Mk212 And 2a Receptor Antagonist Mdl100907 On Maternal Behavior In Postpartum Female Rats, Weihai Chen, Qi Zhang, Wenxin Su, Yu Yang, Jing Qiao, Nan Sui, Ming Li
Department of Psychology: Faculty Publications
Maternal behavior in rats is a highly motivated and well-organized social behavior. Given the known roles of serotonin (5-HT) in emotion, motivation, social behavior, and major depression – and its known interaction with dopamine – it is likely that serotonin also plays a crucial role in this behavior. So far, there are surprisingly few studies focusing on 5-HT in maternal behavior, except for maternal aggression. In the present study,we examined the effects of 5-HT2C receptor agonism and 5-HT2A receptor antagonism on maternal behavior in postpartum female rats.We hypothesized that activation of 5-HT2C receptors and blockade of 5-HT …
The Helminthological Society Of Washington 2013 Anniversary Award: Larry S. Roberts, Sherman S. Hendrix
The Helminthological Society Of Washington 2013 Anniversary Award: Larry S. Roberts, Sherman S. Hendrix
Center for Brain, Biology, and Behavior: Faculty Publications
Dr. Roberts was born in the great state of Texas, and much of his early life is murky, but snakes are often mentioned. Larry received his Bachelor’s degree at Southern Methodist University; his Master of Science at the University of Illinois; and his Doctorate in the Department of Pathobiology at the Johns Hopkins School of Hygiene and Public Health. Larry’s doctoral research, published in Experimental Parasitology, documented the early development and crowding effect of the tapeworm, Hymenolepis diminuta, in the rat small intestine. His publication on this subject opened the door to the golden age of cestode physiology and biochemistry …
Can Helmet Design Reduce The Risk Of Concussion In Football?, Steven Rowson, Stefan M. Duma, Richard M. Greenwald, Jonathan Beckwith, Jeffrey J. Chu, Kevin M. Guskiewicz, Jason P. Mihalik, Joe Crisco, Bethany J. Wilcox, Thomas W. Mcallister, Arthur C. Maerlender, Steven P. Broglio, Brock Schnebel, Scott Anderson, P. Gunnar Brolinson
Can Helmet Design Reduce The Risk Of Concussion In Football?, Steven Rowson, Stefan M. Duma, Richard M. Greenwald, Jonathan Beckwith, Jeffrey J. Chu, Kevin M. Guskiewicz, Jason P. Mihalik, Joe Crisco, Bethany J. Wilcox, Thomas W. Mcallister, Arthur C. Maerlender, Steven P. Broglio, Brock Schnebel, Scott Anderson, P. Gunnar Brolinson
Center for Brain, Biology, and Behavior: Faculty Publications
Of all sports, football accounts for the highest incidence of concussion in the US due to the large number of athletes participating and the nature of the sport. While there is general agreement that concussion incidence can be reduced through rule changes and teaching proper tackling technique, there remains debate as to whether helmet design may also reduce the incidence of concussion. A retrospective analysis was performed of head impact data collected from 1833 collegiate football players who were instrumented with helmet-mounted accelerometer arrays for games and practices. Data were collected between 2005 and 2010 from 8 collegiate football teams: …
Winning And Losing: Differences In Reward And Punishment Sensitivity Between Smokers And Nonsmokers, Laura E. Martin, Lisa S. Cox, William M. Brooks, Cary R. Savage
Winning And Losing: Differences In Reward And Punishment Sensitivity Between Smokers And Nonsmokers, Laura E. Martin, Lisa S. Cox, William M. Brooks, Cary R. Savage
Center for Brain, Biology, and Behavior: Faculty Publications
Background: Smokers show increased brain activation in reward processing regions in response to smoking-related cues, yet few studies have examined secondary rewards not associated with smoking (i.e., money). Inconsistencies exist in the studies that do examine secondary rewards with some studies showing increased brain activation in reward processing brain regions, while others show decreased activation or no difference in activation between smokers and nonsmokers. Aims: The goal of the current study is to see if smokers process the evaluation and delivery of equally salient real world rewards similarly or differently than nonsmokers. Methods: The current study employed functional magnetic resonance …
Repeated Asenapine Treatment Produces A Sensitization Effect In Two Preclinical Tests Of Antipsychotic Activity, Rongyin Qin, Yingzhu Chen, Ming Li
Repeated Asenapine Treatment Produces A Sensitization Effect In Two Preclinical Tests Of Antipsychotic Activity, Rongyin Qin, Yingzhu Chen, Ming Li
Department of Psychology: Faculty Publications
Among several commonly used atypical antipsychotic drugs, olanzapine and risperidone cause a sensitization effect in the conditioned avoidance response (CAR) and phencyclidine (PCP)- induced hyperlocomotion paradigms – two well established animal tests of antipsychotic drugs, whereas clozapine causes a tolerance effect. Asenapine is a novel antipsychotic drug recently approved for the treatment of schizophrenia and manic disorders. It shares several receptor binding sites and behavioral features with other atypical antipsychotic drugs. However, it is not clear what type of repeated effect (sensitization or tolerance) asenapine would induce, and whether such an effect is transferrable to other atypicals. In this study, …
Iptakalim Attenuates Self-Administration And Acquired Goal-Tracking Behavior Controlled By Nicotine, S. Charntikov, N. Swalve, Steven T. Pittenger, K. Fink, S. Schepers, G. C. Hadlock, A. E. Fleckenstein, G. Hu, Ming Li, Rick A. Bevins
Iptakalim Attenuates Self-Administration And Acquired Goal-Tracking Behavior Controlled By Nicotine, S. Charntikov, N. Swalve, Steven T. Pittenger, K. Fink, S. Schepers, G. C. Hadlock, A. E. Fleckenstein, G. Hu, Ming Li, Rick A. Bevins
Department of Psychology: Faculty Publications
Iptakalim is an ATP-sensitive potassium channel opener, as well as an a4b2-containing nicotinic acetylcholine receptor (nAChR) antagonist. Pretreatment with iptakalim diminishes nicotine-induced dopamine (DA) and glutamate release in the nucleus accumbens. This neuropharmacological profile suggests that iptakalim may be useful for treatment of nicotine dependence. Thus, we examined the effects of iptakalim in two preclinical models. First, the impact of iptakalim on the interoceptive stimulus effect of nicotine was evaluated by training rats in a discriminated goal-tracking task that included intermixed nicotine (0.4 mg/kg, SC) and saline sessions. Sucrose was intermittently presented in a responseindependent manner only on nicotine sessions. …
Sex Differences In White Matter Development During Adolescence: A Dti Study, Yingying Wang, Chris Adamson, Weihong Yuan, Mekibib Altaye, Anna W. Byars, Scott K. Holland
Sex Differences In White Matter Development During Adolescence: A Dti Study, Yingying Wang, Chris Adamson, Weihong Yuan, Mekibib Altaye, Anna W. Byars, Scott K. Holland
Center for Brain, Biology, and Behavior: Faculty Publications
Adolescence is a complex transitional period in human development, composing physical maturation, cognitive and social behavioral changes. The objective of this study is to investigate sex differences in white matter development and the associations between intelligence and white matter microstructure in the adolescent brain using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS). In a cohort of 16 typically-developing adolescents aged 13 to 17 years, longitudinal DTI data were recorded from each subject at two time points that were one year apart. We used TBSS to analyze the diffusion indices including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity …
Combined Erp/Fmri Evidence For Early Word Recognition Effects In The Posterior Inferior Temporal Gyrus, Joseph Dien, Eric S. Brian, Dennis L. Molfese, Brian T. Gold
Combined Erp/Fmri Evidence For Early Word Recognition Effects In The Posterior Inferior Temporal Gyrus, Joseph Dien, Eric S. Brian, Dennis L. Molfese, Brian T. Gold
Center for Brain, Biology, and Behavior: Faculty Publications
Two brain regions with established roles in reading are the posterior middle temporal gyrus and the posterior fusiform gyrus. Lesion studies have also suggested that the region located between them, the posterior inferior temporal gyrus (pITG), plays a central role in word recognition. However, these lesion results could reflect disconnection effects since neuroimaging studies have not reported consistent lexicality effects in pITG. Here we tested whether these reported pITG lesion effects are due to disconnection effects or not using parallel ERP/fMRI studies. We predicted that the Recognition Potential (RP), a left-lateralized ERP negativity that peaks at about 200–250 ms, might …
Concordance Of Meg And Fmri Patterns In Adolescents During Verb Generation, Yingying Wang, Scott K. Holland, Jennifer Vannest
Concordance Of Meg And Fmri Patterns In Adolescents During Verb Generation, Yingying Wang, Scott K. Holland, Jennifer Vannest
Center for Brain, Biology, and Behavior: Faculty Publications
In this study we focused on direct comparison between the spatial distributions of activation detected by functional magnetic resonance imaging (fMRI) and localization of sources detected by magnetoencephalography (MEG) during identical language tasks. We examined the spatial concordance between MEG and fMRI results in 16 adolescents performing a three-phase verb generation task that involves repeating the auditorily presented concrete noun and generating verbs either overtly or covertly in response to the auditorily presented noun. MEG analysis was completed using a synthetic aperture magnetometry (SAM) technique, while the fMRI data were analyzed using the general linear model approach with random-effects. To …
A One-Hour Sleep Restriction Impacts Brain Processing In Young Children Across Tasks: Evidence From Event-Related Potentials, Dennis Molfese, Anna Ivanenko, Alexandra P.F. Key, Adrienne Roman, Victoria J. Molfese, Louise M. O'Brien, David Gozal, Srinivas Kota, Caitlin M. Hudac
A One-Hour Sleep Restriction Impacts Brain Processing In Young Children Across Tasks: Evidence From Event-Related Potentials, Dennis Molfese, Anna Ivanenko, Alexandra P.F. Key, Adrienne Roman, Victoria J. Molfese, Louise M. O'Brien, David Gozal, Srinivas Kota, Caitlin M. Hudac
Center for Brain, Biology, and Behavior: Faculty Publications
The effect of mild sleep restriction on cognitive functioning in young children is unclear, yet sleep loss may impact children's abilities to attend to tasks with high processing demands. In a preliminary investigation, six children (6.6 - 8.3 years of age) with normal sleep patterns performed three tasks: attention (“Oddball”), speech perception (conconant-vowel syllables) and executive function (Directional Stroop). Event-related potentials (ERP) responses were recorded before (Control) and following one-week of 1-hour per day of sleep restriction. Brain activity across all tasks following Sleep Restriction differed from activity during Control Sleep, indicating that minor sleep restriction impacts children's neurocognitive functioning.
Normative Topographic Erp Analyses Of Speed Of Speech Processing And Grammar Before And After Grammatical Treatment, Paul J. Yoder, Dennis Molfese, Micah M. Murray, Alexandra P.F. Key
Normative Topographic Erp Analyses Of Speed Of Speech Processing And Grammar Before And After Grammatical Treatment, Paul J. Yoder, Dennis Molfese, Micah M. Murray, Alexandra P.F. Key
Center for Brain, Biology, and Behavior: Faculty Publications
Typically developing (TD) preschoolers and age-matched preschoolers with specific language impairment (SLI) received event-related potentials (ERPs) to four monosyllabic speech sounds prior to treatment and, in the SLI group, after 6 months of grammatical treatment. Before treatment, the TD group processed speech sounds faster than the SLI group. The SLI group increased the speed of their speech processing after treatment. Post-treatment speed of speech processing predicted later impairment in comprehending phrase elaboration in the SLI group. During the treatment phase, change in speed of speech processing predicted growth rate of grammar in the SLI group.