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Full-Text Articles in Neuroscience and Neurobiology
Nontraditional Epilepsy Treatment Approaches, Michael A. Rogawski, Gregory L. Holmes
Nontraditional Epilepsy Treatment Approaches, Michael A. Rogawski, Gregory L. Holmes
Michael A. Rogawski
Overview of articles published in a special issue of Neurotherapeutics (April 2009) on nontraditional (non-drug) epilepsy treatment approaches. From the Fourth Workshop on New Horizons in the Development of Antiepileptic Drugs: Nontraditional Approaches to Treat Epilepsy, which was held at the Clontarf Castle, Dublin, March 5-7, 2008.
A Catalog Of Scn1a Variants, Christoph Lossin
A Catalog Of Scn1a Variants, Christoph Lossin
Christoph Lossin, Ph.D.
Over the past 10 years mutations in voltage-gated sodium channels (Navs) have become closely associated with inheritable forms of epilepsy. One isoform in particular, Nav1.1 (gene symbol SCN1A), appears to be a superculprit, registering with more than 330 mutations to date. The associated phenotypes range from benign febrile seizures to extremely serious conditions, such as Dravet’s syndrome (SMEI). Despite the wealth of information, mutational analyses are cumbersome, owing to inconsistencies among the Nav1.1 sequences to which different research groups refer. Splicing variability is the core problem: Nav1.1 co-exists in three isoforms, two of them lack 11 or 28 amino acids …