Neuroscience and Neurobiology Commons^™

Brain, Mind And Behaviour - Emerging Biological Connections, Amresh Srivastava

Amresh Srivastava

No abstract provided.

A Cyclin A-Protein Kinase Complex Possesses Sequence-Specific Dna Binding Activity: P33 Is A Component Of The E2f Cyclin-A Complex, Stephen Devoto

Stephen Devoto

No abstract provided.

Regression When The Predictors Are Images, Philip T. Reiss

Philip T. Reiss

No abstract provided.

Nontraditional Epilepsy Treatment Approaches, Michael A. Rogawski, Gregory L. Holmes

Michael A. Rogawski

Overview of articles published in a special issue of Neurotherapeutics (April 2009) on nontraditional (non-drug) epilepsy treatment approaches. From the Fourth Workshop on New Horizons in the Development of Antiepileptic Drugs: Nontraditional Approaches to Treat Epilepsy, which was held at the Clontarf Castle, Dublin, March 5-7, 2008.

Convection-Enhanced Delivery In The Treatment Of Epilepsy, Michael A. Rogawski

Michael A. Rogawski

Convection-enhanced delivery (CED) is a novel drug-delivery technique that uses positive hydrostatic pressure to deliver a fluid containing a therapeutic substance by bulk flow directly into the interstitial space within a localized region of the brain parenchyma. CED circumvents the blood-brain barrier and provides a wider, more homogenous distribution than bolus deposition (focal injection) or other diffusion-based delivery approaches. A potential use of CED is for the local delivery of antiseizure agents, which would provide an epilepsy treatment approach that avoids the systemic toxicities of orally administered anti-epileptic drugs and bystander effects on nonepileptic brain regions. Recent studies have demonstrated …

Brain Activation For Reading And Listening Comprehension: An Fmri Study Of Modality Effects And Individual Differences In Language Comprehension., Augusto Buchweitz, Robert Mason, Tomitch Leda, Marcel Just

Marcel Adam Just

No abstract provided.

Altering Cortical Connectivity: Remediation-Induced Changes In The White Matter Of Poor Readers, Timothy Keller, Marcel Just

Marcel Adam Just

No abstract provided.

Topiramate Reduces Excitability In The Basolateral Amygdala By Selectively Inhibiting Gluk1 (Glur5) Kainate Receptors On Interneurons And Positively Modulating Gaba-A Receptors On Principal Neurons, Maria Braga, Vassiliki Aroniadou-Anderjaska, He Li, Michael Rogawski

Michael A. Rogawski

Topiramate [2,3:4,5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate] is a structurally novel antiepileptic drug that has broad efficacy in epilepsy, but the mechanisms underlying its therapeutic activity are not fully understood. We have found that topiramate selectively inhibits GluK1 (GluR5) kainate receptor-mediated excitatory postsynaptic responses in rat basolateral amygdala (BLA) principal neurons and protects against seizures induced by the GluK1 kainate receptor agonist (R,S)-2-amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid (ATPA). Here, we demonstrate that topiramate also modulates inhibitory function in the BLA. Using whole-cell recordings in rat amygdala slices, we found that 0.3 to 10 microM topiramate 1) inhibited ATPA-evoked postsynaptic currents recorded from BLA interneurons; 2) suppressed ATPA-induced …

The Effect Of Lexical And Sublexical Frequency On Speech Production: An Fmri Investigation, Linda Shuster

Linda Shuster

No abstract provided.

Myotonia Congenita, Christoph Lossin, Alfred George

Christoph Lossin, Ph.D.

Myotonia is a symptom of many different acquired and genetic muscular conditions that impair the relaxation phase of muscular contraction. Myotonia congenital is a specific inherited disorder of muscle membrane hyperexcitability caused by reduced sarcolemmal chloride conductance due to mutations invCLCN1, the gene coding for the main skeletal muscle chloride channel ClC-1.The disorder may be transmitted as either an autosomal-dominant or recessive trait with close to 130 currently known mutations. Although this is a rare disorder, elucidation of the pathophysiology underlying myotonia congenital established the importance of sarcolemmal chloride conductance in the control of muscle excitability and demonstrated the first …

Connectivity Analysis Reveals A Cortical Network For Eye Gaze Perception., Lauri Nummenmaa, Luca Passamonti, James Rowe, Andrew Engell, Andy Calder

Andrew Engell

Polymorphisms Of Delta-Aminolevulinic Acid Dehydratase (Alad) And Peptide Transporter 2 (Pept2) Genes In Children With Low-Level Lead Exposure, Christina Sobin, Marisela Gutierrez, Heather Alterio

Christina Sobin, Ph.D.

Low-level lead exposure during early childhood has long been associated with altered neurocognitive development and diminished cognitive functions. Over nine thousand U.S. industrial facilities annually emit significant amounts of lead, creating exposure risk particularly for minority children. The mechanisms by which low-level lead exerts neurotoxic effects are poorly understood. Once absorbed, the only intervention is source removal, thus primary prevention is key. Genetic biomarkers could provide an efficient means of identifying children at greatest risk. Common functional variants of genes that alter lead’s neurotoxic potential have been identified and include delta-aminolevulinic acid dehydratase (ALAD2) and peptide transporter 2 (PEPT2*2). These …

A Catalog Of Scn1a Variants, Christoph Lossin

Christoph Lossin, Ph.D.

Over the past 10 years mutations in voltage-gated sodium channels (Navs) have become closely associated with inheritable forms of epilepsy. One isoform in particular, Nav1.1 (gene symbol SCN1A), appears to be a superculprit, registering with more than 330 mutations to date. The associated phenotypes range from benign febrile seizures to extremely serious conditions, such as Dravet’s syndrome (SMEI). Despite the wealth of information, mutational analyses are cumbersome, owing to inconsistencies among the Nav1.1 sequences to which different research groups refer. Splicing variability is the core problem: Nav1.1 co-exists in three isoforms, two of them lack 11 or 28 amino acids …

Japanese And English Sentence Reading Comprehension And Writing Systems: An Fmri Study Of First And Second Language Effects On Brain Activation, Augusto Buchweitz, Robert A. Mason, Akiko Hasegawa, Marcel Adam Just

Marcel Adam Just

No abstract provided.

Pathological Alterations In Gabaergic Interneurons And Reduced Tonic Inhibition In The Basolateral Amygdala During Epileptogenesis, Michael A. Rogawski, Brita Fritsch, Felicia Qashu, T. H. Figueiredo, Vicki Aroniadou-Anderjaska, Maria F.M. Braga

Michael A. Rogawski

An acute brain insult such as traumatic head/brain injury, stroke, or an episode of status epilepticus can trigger epileptogenesis, which, after a latent, seizure-free period, leads to epilepsy. The discovery of effective pharmacological interventions that can prevent the development of epilepsy requires knowledge of the alterations that occur during epileptogenesis in brain regions that play a central role in the induction and expression of epilepsy. In the present study, we investigated pathological alterations in GABAergic interneurons in the rat basolateral amygdala (BLA), and the functional impact of these alterations on inhibitory synaptic transmission, on days 7 to 10 after status …

Atypical Frontal-Posterior Synchronization Of Theory Of Mind Regions In Autism During Mental State Attribution, Rajesh K. Kana, Timothy A. Keller, Vladimir L. Cherkassky, Nancy J. Minshew, Marcel Adam Just

Marcel Adam Just

No abstract provided.

The Role Of The Theory-Of-Mind Cortical Network In The Comprehension Of Narratives, Robert Mason, Marcel Just

Marcel Adam Just

No abstract provided.

Protracted Withdrawal From Alcohol And Drugs Of Abuse Impairs Long-Term Potentiation Of Intrinsic Excitability In The Juxtacapsular Bed Nucleus Of The Stria Terminalis, Laura O'Dell

Laura Elena O'Dell

No abstract provided.

The Effects Of Opioids And Opioid Analogs On Animal And Human Endocrine Systems, Laura O'Dell

Laura Elena O'Dell

No abstract provided.

Pdf Of All O'Dell Manuscripts, Laura O'Dell

Laura Elena O'Dell

No abstract provided.