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Full-Text Articles in Neuroscience and Neurobiology
Neuron Morphology Influences Axon Initial Segment Plasticity, Allan T. Gulledge, Jaime J. Bravo
Neuron Morphology Influences Axon Initial Segment Plasticity, Allan T. Gulledge, Jaime J. Bravo
Dartmouth Scholarship
In most vertebrate neurons, action potentials are initiated in the axon initial segment (AIS), a specialized region of the axon containing a high density of voltage-gated sodium and potassium channels. It has recently been proposed that neurons use plasticity of AIS length and/or location to regulate their intrinsic excitability. Here we quantify the impact of neuron morphology on AIS plasticity using computational models of simplified and realistic somatodendritic morphologies. In small neurons (e.g., dentate granule neurons), excitability was highest when the AIS was of intermediate length and located adjacent to the soma. Conversely, neurons having larger dendritic trees (e.g., pyramidal …
Axon Initial Segment Loss Is Not Observed In The Hippocampus Of A Experimental Autoimmune Encephalomyelitis Mouse Model, Praveen Mohanraju
Axon Initial Segment Loss Is Not Observed In The Hippocampus Of A Experimental Autoimmune Encephalomyelitis Mouse Model, Praveen Mohanraju
Undergraduate Research Posters
The axon initial segment (AIS) is fundamental for neuronal communication and action potential initiation, a characteristic which has been shown to be disrupted in inflammatory diseases such as Multiple Sclerosis (MS). Previous work from our lab has shown AIS breakdown in layer 5 of the cortex in a mouse model of MS known as experimental autoimmune encephalomyelitis (EAE). Moreover, it was shown that AIS breakdown was independent of demyelination but temporally correlated with microglial inflammatory reactivity. In order to determine if this pathology is specific to the cortex or affects other regions of the brain, we exploited these EAE induced …