Neuroscience and Neurobiology Commons^™

Functional Properties Of L-Glutamate Regulation In Anesthetized And Freely Moving Mice, Kevin N. Hascup

Theses and Dissertations--Neuroscience

L-glutamate (Glu) is the predominant excitatory neurotransmitter in the mammalian central nervous system with involvement encompassing learning and memory, cognition, plasticity, and motor movement. Dysregulation of the glutamatergic system is implicated in several neurological disorders including Parkinson’s disease, Alzheimer’s disease, Huntington’s disease and amyotrophic lateral sclerosis. The mechanisms underlying these neurological disorders are not clear, but evidence suggests that abnormal Glu neurotransmission plays a role. Elevated levels of Glu in the synaptic cleft overstimulate the N-methyl-Daspartate receptor leading to excitotoxicity, which causes neuronal loss in chronic neurological diseases. What is less understood is the source for the elevated Glu levels. …

Functional Neuroimaging And The Law: Trends And Directions For Future Scholarship, Stacey A. Tovino

Faculty Articles

Under the umbrella of the burgeoning neurotransdisciplines, scholars are using the principles and research methodologies of their primary and secondary fields to examine developments in neuroimaging, neuromodulation, and psychopharmacology. The path for advanced scholarship at the intersection of law and neuroscience may clear if work across the disciplines is collected and reviewed and outstanding and debated issues are identified and clarified. In this article, I organize, examine and refine a narrow class of burgeoning neurotransdiscipline scholarship; that is, scholarship at the interface of law and functional magnetic resonance imaging.

Optimization Of Biomathematical Model Predictions For Cognitive Performance Impairment In Individuals: Accounting For Unknown Traits And Uncertain States In Homeostatic And Circadian Processes, Hans P. A. Van Dongen, Christopher G. Mott, Jen-Kuang Huang, Daniel J. Mollicone, Frederic D. Mckenzie, David F. Dinges

Mechanical & Aerospace Engineering Faculty Publications

Current biomathematical models of fatigue and performance do not accurately predict cognitive performance for individuals with a priori unknown degrees of trait vulnerability to sleep loss, do not predict performance reliably when initial conditions are uncertain, and do not yield statistically valid estimates of prediction accuracy, These limitations diminish their usefulness for predicting the performance of individuals in operational environments. To overcome these 3 limitations, a novel modeling approach was developed, based on the expansion of a statistical technique called Bayesian forecasting. The expanded Bayesian forecasting procedure was implemented in the two-process model of sleep regulation, which has been used …

Confidence Intervals For Individualized Performance Models, Hans P. A. Van Dongen, Christopher G. Mott, Jen-Kuang Huang, Daniel J. Millicone, Frederic D. Mckenzie, David F. Dinges

Mechanical & Aerospace Engineering Faculty Publications

Commentary on Reifman J; Rajaraman S; Gribok AV. Moving Towards Individualized Performance Models. Sleep 2007;30(9):1081-82.

Neuromechanics Of Multifunctionality During Rejection In Aplysia Californica, Hui Ye, Douglas W. Morton, Hillel J. Chiel

Faculty Scholarship

How are the same muscles and neurons used to generate qualitatively different behaviors? We studied this question by analyzing the biomechanical and neural mechanisms of rejection responses in the marine mollusk Aplysia californica and compared these mechanisms with those used to generate swallowing responses (Ye et al., 2006). During rejection, the central grasper of the feeding structure closes to push inedible food out of the buccal cavity. This contrasts with swallowing, during which the grasper is open as it moves toward the jaws (protracts). We examined how the shape change of the grasper during rejection mechanically reconfigured the surrounding musculature. …

Dissociation Of Automatic And Strategic Lexical-Semantics: Functional Magnetic Resonance Imaging Evidence For Differing Roles Of Multiple Frontotemporal Regions, Brian T. Gold, David A. Balota, Sara J. Jones, David K. Powell, Charles D. Smith, Anders H. Andersen

Neuroscience Faculty Publications

Behavioral research has demonstrated three major components of the lexical-semantic processing system: automatic activation of semantic representations, strategic retrieval of semantic representations, and inhibition of competitors. However, these component processes are inherently conflated in explicit lexical-semantic decision tasks typically used in functional magnetic resonance imaging (fMRI) research. Here, we combine the logic of behavioral priming studies and the neurophysiological phenomenon of fMRI priming to dissociate the neural bases of automatic and strategic lexical-semantic processes across a series of three studies. A single lexical decision task was used in all studies, with stimulus onset asynchrony or linguistic relationship between prime and …

Activation In Neural Networks Controlling Ingestive Behaviors: What Does It Mean, And How Do We Map And Measure It?, Alan Watts, Arshad Khan, Graciela Sanchez-Watts, Dawna Salter, Christina Neuner

Selected Works Temporary Series

No abstract provided.

Activation In Neural Networks Controlling Ingestive Behaviors: What Does It Mean, And How Do We Map And Measure It?, Watts, Arshad Khan, Graciela Sanchez-Watts, Dawna Salter, Christina Neuner

Departmental Papers (Biology)

No abstract provided.

Art Therapy With Adults With Autism, Kimberly Dennler

EVMS School of Health Professions Theses & Dissertations

Research regarding art therapy with adults with autism is limited. The objective of this study was to understand the effect of a specific art therapy intervention upon social interaction and communication of the adults with autism. The hypothesis was that by participating in this intervention, the participants’ communication and socialization would increase and their maladaptive behaviors would decrease. Over a series of nine sessions, the five participants from Bittersweet Farms were introduced to basic techniques for working with clay.

Results were based on qualitative analysis of data from staff surveys, through the use of pre and post questionnaires; observations made …

Prenatal Cocaine Exposure Alters Alpha2 Receptor Expression In Adolescent Rats, Rosemarie M. Booze, David R. Wallace, Janelle M. Silvers, Barbara J. Strupp, Diane M. Snow, Charles F. Mactutus

Neuroscience Faculty Publications

BACKGROUND: Prenatal cocaine exposure produces attentional deficits which to persist through early childhood. Given the role of norepinephrine (NE) in attentional processes, we examined the forebrain NE systems from prenatal cocaine exposed rats. Cocaine was administered during pregnancy via the clinically relevant intravenous route of administration. Specifically, we measured alpha2-adrenergic receptor (alpha2-AR) density in adolescent (35-days-old) rats, using [3H]RX821002 (5 nM).

RESULTS: Sex-specific alterations of alpha2-AR were found in the hippocampus and amygdala of the cocaine-exposed animals, as well as an upregulation of alpha2-AR in parietal cortex.

CONCLUSION: These data suggest that prenatal cocaine exposure results in a persistent alteration …

Cyclooxygenase-2 Mediates Microglial Activation And Secondary Dopaminergic Cell Death In The Mouse Mptp Model Of Parkinson's Disease, Rattanavijit Vijitruth, Mei Liu, Dong-Young Choi, Xuan V. Nguyen, Randy L. Hunter, Guoying Bing

Neuroscience Faculty Publications

BACKGROUND: Accumulating evidence suggests that inflammation plays an important role in the progression of Parkinson's disease (PD). Among many inflammatory factors found in the PD brain, cyclooxygenase (COX), specifically the inducible isoform, COX-2, is believed to be a critical enzyme in the inflammatory response. Induction of COX-2 is also found in an experimental model of PD produced by administration of 1-methy-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

METHOD: COX-2-deficient mice or C57BL/6 mice were treated with MPTP to investigate the effects of COX-2 deficiency or by using various doses of valdecoxib, a specific COX-2 inhibitor, which induces inhibition of COX-2 on dopaminergic neuronal toxicity and …

Neuromechanics Of Coordination During Swallowing In Aplysia Californica, Hui Ye, Douglas W. Morton, Hillel J. Chiel

Faculty Scholarship

Bernstein (1967) hypothesized that preparation of the periphery was crucial for correct responses to motor output. To test this hypothesis in a behaving animal, we examined the roles of two identified motor neurons, B7 and B8, which contribute to feeding behavior in the marine mollusk Aplysia californica. Neuron B7 innervates a hinge muscle and has no overt behavioral effect during smaller-amplitude (type A) swallows, because the hinge muscle is too short to exert force. Neuron B8 activates a muscle (I4) that acts solely to grasp material during type A swallows. During larger-amplitude (type B) swallows, the behavioral actions of both …

Word Association Tests Of Associative Memory And Implicit Processes: Theoretical And Assessment Issues, Alan W. Stacy, Susan L. Ames, Jerry L. Grenard

CGU Faculty Publications and Research

Word association is one of the most commonly used measures of association in cognitive science. These tests have been used to infer association parameters in normative studies, to derive cues and primes used in diverse paradigms (semantic priming, cued recall, illusory memory), to test implicit memory in experimental studies, and to suggest the operation of implicit processes in nonexperimental work. This chapter briefly outlines some of the historical routes and current controversies about association and summarizes basic cognitive research applying associative tests. The authors then describe benefits and limitations of the tests, as well as implications for theory and interventions …

The Effect Of Handling Time On Temporal Discounting In Two New World Primates, Alexandra G. Rosati, Jeffrey R. Stevens, Marc D. Hauser

Center for Brain, Biology, and Behavior: Faculty Publications

Foraging decisions in nonhuman animals often require choosing between small, immediate food rewards and larger, more delayed rewards. Faced with such choices, animals typically discount or devalue the future quite strongly. Although discounting studies often focus on delays to reward access, other temporal intervals contribute to foraging rate, and thus may potentially influence discounting levels. Here, we examine the effect of handling time, the time required to process and consume food, on discounting in cottontop tamarins, Saguinus oedipus, and common marmosets, Callithrix jacchus, two species that differ in levels of temporal discounting. We presented subjects with a discounting task under …

Effects Of Gesture+Verbal Treatment For Noun And Verb Retrieval In Aphasia, Anastasia M. Raymer, Floris Singletary, Amy Rodriguez, Maribel Ciampitti, Kenneth M. Heilman, Leslie J. Gonzalez Rothi

Communication Disorders & Special Education Faculty Publications

Links between verbs and gesture knowledge suggest that verb retrieval may be particularly amenable to gesture+verbal training (GVT) in aphasia compared to noun retrieval. This study examines effects of GVT for noun and verb retrieval in nine individuals with aphasia subsequent to left hemisphere stroke. Participants presented an array of noun and verb retrieval deficits, including impairments of semantic and/or phonologic processing. In a single-participant experimental design, we investigated effects of GVT for noun and verb retrieval in two counterbalanced treatment phases. Effects were evaluated in spoken naming and gesture production to pictured objects and actions. Spoken naming improvements associated …

The Effects Of An Analgesic (Biofreeze®) On The Motoneuron Pool Excitability Of The Soleus Muscle, Desiree R. Barth

All-Inclusive List of Electronic Theses and Dissertations

Objective: The purpose of this study was to determine the effects on the Hoffman reflex and motor response with an analgesic (Biofreeze®). Design: The study was a 2X6 design. The independent variables in this study were treatment and time. The dependent variables were the H-reflex (volts) and the M response (volts). Treatment was randomly assigned to control for the effects of order. Setting: This study took place in the Exercise Physiology Laboratory located in the Health and Human Performance Building at Indiana State University. Subjects: 14 volunteers who were physically active and had no known neurological problems. Measurements: Skin and …

Sheep Updates 2005 - Part 1, R. W. Kelly, R. Kingwell, A. R. Bray, Chris Oldham, Graeme Martin, D. Blanche, D. Ferguson, Keith Crocker, Di Evans

Sheep Updates

This session covers seven papers from different authors: Boosting lambing percentages of WA sheep flocks. R.W. Kelly CSIRO Livestock Industries, Floreat WA , R. Kingwell Department of Agriculture WA,

Kiwis can fly - 30% higher lambing in 15 years, AR Bray, Meat and Wool New Zealand, Wellington, New Zealand

Rams are not a trivial expense, so what can you do to maximise on your investment? Chri Oldham, Department of Agriculture Western Australia, Graeme Martin, University of West Australia.

Care for mun - fetal programming, lamb survival and lifetime performance. RW Kelly CSIRO Livestock Industries, Floreat WA

Boost lamb survival - …

A New Interpretation Of The Drug Levodopa In The Treatment Of Parkinson's Disease, Joanne T. Vannah

Graduate Masters Theses

An argument for levodopa induced dyskinesias (LID) as an expression of long term potentiation (LTP) in the striatum is presented. Normally, with an intact nigrostriatal dopamine (DA) input, long term depression (LTD) is expressed in the striatum, however, striatal LTD is lost following DA denervation and chronic levodopa treatment. It is possible that these changes in synaptic efficacy are due to two other chemical modulators, achetylcholine (ACh) and glutamate, which in turn leads to the induction of striatal LTP. ACh and glutamate may produce these changes in motor behavior by affecting the striosomal pathway in addition to their effect on …

Lateral Hypothalamic Signaling Mechanisms Underlying Feeding Stimulation: Differential Contributions Of Src Family Tyrosine Kinases To Feeding Triggered Either By Nmda Injection Or By Food Deprivation, Arshad Khan, Herman Cheung, Elizabeth Gillard, Jennifer Palarca, Derek Welsbie, James Gurd, B. Stanley

Selected Works Temporary Series

No abstract provided.

Lateral Hypothalamic Signaling Mechanisms Underlying Feeding Stimulation: Differential Contributions Of Src Family Tyrosine Kinases To Feeding Triggered Either By Nmda Injection Or By Food Deprivation, Khan, Herman Cheung, Elizabeth Gillard, Jennifer Palarca, Derek Welsbie, James Gurd, B. Stanley

Departmental Papers (Biology)

No abstract provided.

Intravenous 2-Deoxy-D-Glucose Injection Rapidly Elevates Levels Of The Phosphorylated Forms Of P44/42 Mitogen-Activated Protein Kinases (Extracellularly Regulated Kinases 1/2) In Rat Hypothalamic Parvicellular Paraventricular Neurons, Arshad Khan, Alan Watts

Selected Works Temporary Series

No abstract provided.

Neurologically Plausible Distinctions In Cognition Relevant To Drug Use Etiology And Prevention, Alan W. Stacy, Susan L. Ames, Barbara J. Knowlton

CGU Faculty Publications and Research

This article outlines several distinctions in cognition and related topics in emotion that receive support from work in cognitive neuroscience and have important implications for prevention: implicit cognition, working memory, nonverbal memory, and neurobiological systems of habit. These distinctions have not been widely acknowledged or applied in drug use prevention research, despite their neural plausibility and the availability of methods to make this link. The authors briefly review the basis for the distinctions and indicate general implications and assessment possibilities for prevention researchers conducting large-scale field trials. Subsequently, the article outlines a connectionist framework for specific applications in prevention interventions. …

Intravenous 2-Deoxy-D-Glucose Injection Rapidly Elevates Levels Of The Phosphorylated Forms Of P44/42 Mitogen-Activated Protein Kinases (Extracellularly Regulated Kinases 1/2) In Rat Hypothalamic Parvicellular Paraventricular Neurons, Khan, Alan Watts

Departmental Papers (Biology)

No abstract provided.

Visual Enhancing Of Tactile Perception In The Posterior Parietal Cortex, Tony Ro, Ruth Wallace, Judith Hagedorn, Alessandro Farnè, Elizabeth Pienkos

Publications and Research

The visual modality typically dominates over our other senses. Here we show that after inducing an extreme conflict in the left hand between vision of touch (present) and the feeling of touch (absent), sensitivity to touch increases for several minutes after the conflict. Transcranial magnetic stimulation of the posterior parietal cortex after this conflict not only eliminated the enduring visual enhancement of touch, but also impaired normal tactile perception. This latter finding demonstrates a direct role of the parietal lobe in modulating tactile perception as a result of the conflict between these senses. These results provide evidence for visual-to-tactile perceptual …

Radiation Effects On Dopamine-Mediated Prepulse Inhibition In The C57bl/6 Mouse, Cara Nicole Zuccarelli Miller

Loma Linda University Electronic Theses, Dissertations & Projects

This study examined the effects of proton and gamma radiation on a dopamine-dependent sensory gating mechanism: prepulse inhibition of the startle reflex. The purpose of this research was to describe potential hazards of proton radiation to the central nervous system in long-term space fight and for proton therapy patients. Results from previous research indicate that startle behavior is modified by proton and iron radiation. Forty-eight 10-½ week old, male C57BL/6 mice were used to characterize the optimal parameters for the model (prepulse duration, probe duration, and stimulus-onset-asynchrony). Three hundred and fifty two mice were used to characterize the time course …

The Response Of The Hoffmann Reflex To Endurance Training In Male Cross-Country Runners, Randall J. Bergman

All-Inclusive List of Electronic Theses and Dissertations

Motoneuron pool excitability as measured by the Hoffinann reflex (H-reflex) in endurance-trained subjects has been shown to differ from their untrained counterparts. Further, the effects of endurance training on the H-reflex are equivocal. Objective: To determine if differences exist in the motoneuron pool excitability of the soleus in highly trained endurance athletes due to the effect of endurance training. Design: A 2 X 3 factorial design with repeated measures. Setting: This study took place in the Exercise Physiology Laboratory located in the Health and Human Performance Building on the Indiana State University campus. Subjects: Eleven male cross-country team members (XC; …

Do Cellular Phones Cause Headaches?, Jasmine Gay

McCabe Thesis Collection

Many people have recently complained about experiencing headaches in association with the use of their cellular telephones. There is much controversy over this subject because it has not yet been proven that the microwaves emitted by cellular telephones cause headaches. The research questions include the following: What are the effects, if any, of the use of cellular telephones on human health? Do they cause headaches? Are they responsible for the increase in size of some brain tumors?

There have been many experiments performed by various scientists in the field of bioelectromagnetics and by the World Health Organization (WHO); however, these …

Focal Temperature Change Facilitates The Peak-To-Peak Soleus Hoffmann Reflex And Muscle Response, Bentley Andrew Krause

All-Inclusive List of Electronic Theses and Dissertations

Objective: Cryotherapy is a widely used rehabilitative modality in sports medicine. Cooling joint tissues has been observed to facilitate active exercise following injury. Mechanisms effecting motoneuron recruitment during and following cryotherapy are presumed to be both local and central in nature. Focal cooling facilitates motoncuron pool recruitment and may alter the excitability of motoncurons. The purpose of this investigation was to determine if changes in focal temperature alter the characteristics of the maximum peak-to-peak Hoffmann reflex (Hmax) and muscle response (Mmax). Design and setting: A 4x5 factorial design with repeated measures on time was used in this study. Hmax and …

Ipsilesional Biases In Saccades But Not Perception After Lesions Of The Human Inferior Parietal Lobule, Tony Ro, Chris Rorden, Jon Driver, Robert Rafal

Publications and Research

We examined the effects of chronic unilateral lesions to either the inferior parietal lobe, or to the dorsolateral prefrontal cortex including the frontal eye fields (FEFs), upon human visual perception and saccades in temporal-order-judgment (TOJ) tasks. Two visual events were presented on each trial, one in each hemifield at various stimulus onset asynchronies (SOAs). In the saccade task, patients moved their eyes to whichever stimulus attracted gaze first. In the perceptual-manual task, they pressed a button to indicate which stimulus was perceived first. Frontal patients showed appropriate TOJs for visual targets in both tasks. Parietal patients showed appropriate TOJs in …

Neuromotor And Cognitive Development In Children With Cerebral Palsy In Relation To Neural Plasticity, Vaniecea Pollard

McCabe Thesis Collection

Infants with neurological disabilities, such as cerebral palsy (CP) and Down syndrome (DS), show severe delays in motor and cognitive development relative to chronological age. Involvement of neural plasticity as a treatment of such neurological disorders is increasingly being seen. Previous studies have found that interventions involving sensory linked motor performance have been critical in facilitating motor improvement. The purpose of this study was to compare self-initiated mobility in children with CP and DS. Three infants, ages 8, 9, and 22 months, with diagnoses of no CP, DS, and CP respectively, participated in the study. The infants were videotaped in …