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Activity Of T-705 In A Hamster Model Of Yellow Fever Virus Infection In Comparison With That Of A Chemically Related Compound, T-1106, J G. Julander, K Shafer, D F. Smee, John D. Morrey, Y Furuta
Activity Of T-705 In A Hamster Model Of Yellow Fever Virus Infection In Comparison With That Of A Chemically Related Compound, T-1106, J G. Julander, K Shafer, D F. Smee, John D. Morrey, Y Furuta
John D. Morrey
Treatment with the nucleoside analog T-1106 was previously shown to be effective in a hamster model of yellow fever virus (YFV) disease, even though it had only slight activity in cell culture. In the study described in this report, the activity of T-705, a chemically related compound currently undergoing clinical trials for the treatment of influenza (FDANews 4:1, 2007), was tested against YFV in cell culture and in the hamster model. The antiviral efficacy of T-705 in cell culture occurred at a concentration of 330 µM, which was more than threefold lower than the concentration at which T-1106 had antiviral …