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Articles 1 - 4 of 4
Full-Text Articles in Virology
Artificial Intelligence And Machine Learning Based Techniques In Analyzing The Covid-19 Gene Expression Data: A Review, Santhosh K, Ajitha S, Sushma Pradeep, Kuralyanapalya Putta Honnappa Suresh, Sharanagouda S Patil, Shiva Prasad Kollur, Chandan Shivmallu
Artificial Intelligence And Machine Learning Based Techniques In Analyzing The Covid-19 Gene Expression Data: A Review, Santhosh K, Ajitha S, Sushma Pradeep, Kuralyanapalya Putta Honnappa Suresh, Sharanagouda S Patil, Shiva Prasad Kollur, Chandan Shivmallu
International Journal of Health and Allied Sciences
The novel Coronavirus associated with respiratory illness has become a new threat to human health as it is spreading very rapidly among the human population. Scientists and healthcare specialists throughout the world are still looking for a breakthrough technology to help combat the Covid-19 outbreak, despite the recent worldwide urgency. The use of Machine Learning (ML) and Artificial Intelligence (AI) in earlier epidemics has encouraged researchers by providing a fresh approach to combating the latest Coronavirus pandemic. This paper aims to comprehensively review the role of AI and ML for analysis of gene expressed data of COVID-19
Role Of Tetraspanins In Sars-Cov-2 Fusion And Entry, Marcos Saul Santiago Figueroa
Role Of Tetraspanins In Sars-Cov-2 Fusion And Entry, Marcos Saul Santiago Figueroa
Master's Theses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the pandemic the world has been facing in recent years. Even as new countermeasures are developed, there is still much we don’t know in terms of its entry into host cells. Tetraspanins are transmembrane proteins that are near ubiquitous amongst cell types. They fulfill numerous roles, including that of a viral co-receptor. Here, we considered whether tetraspanins, specifically CD9, CD63, and CD81 influence SARS-CoV-2 fusion and entry. Using ACE2-LgBit and tetraspanin overexpressing EVs and HeLa cells, we find that the presence of excess tetraspanins inhibit fusion and entry. However, we …
Regulation Of Mhc Ii Trafficking And Expression By Host And Viral Factors, Alex Lac
Regulation Of Mhc Ii Trafficking And Expression By Host And Viral Factors, Alex Lac
Electronic Thesis and Dissertation Repository
Antigen presentation by major histocompatibility complex class II (MHC II) to the adaptive immune system is crucial for mounting sterilizing immune responses. This central role has made antigen presentation a target for antagonism by many pathogens. Notably, infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) decrease MHC II expression in several immune cells. The mechanisms responsible for this suppression are unknown but involves either redirecting MHC II molecules away from the cell surface or inhibiting MHC II expression. To understand how pathogens manipulate intracellular MHC II trafficking, we first investigated the role of the Golgi trafficking regulator, ERC1, in …
Insights To Protein Pathogenicity From The Lens Of Protein Evolution, Janelle Nunez-Castilla
Insights To Protein Pathogenicity From The Lens Of Protein Evolution, Janelle Nunez-Castilla
FIU Electronic Theses and Dissertations
As protein sequences evolve, differences in selective constraints may lead to outcomes ranging from sequence conservation to structural and functional divergence. Evolutionary protein family analysis can illuminate which protein regions are likely to diverge or remain conserved in sequence, structure, and function. Moreover, nonsynonymous mutations in pathogens may result in the emergence of protein regions that affect the behavior of pathogenic proteins within a host and host response. I aimed to gain insight on pathogenic proteins from cancer and viruses using an evolutionary perspective. First, I examined p53, a conformationally flexible, multifunctional protein mutated in ~50% of human cancers. Multifunctional …