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Spatial Localization Of Markers And 3d-Cell Model For Study Of The Human Cytomegalovirus Cytoplasmic Virion Assembly Compartment, Taylor Alan Vensko
Spatial Localization Of Markers And 3d-Cell Model For Study Of The Human Cytomegalovirus Cytoplasmic Virion Assembly Compartment, Taylor Alan Vensko
Wayne State University Theses
Human cytomegalovirus (HCMV) causes severe disease in immunocompromised individuals and is a leading cause of congenital disease. Efficient assembly of virions (viral particles) is an intricate process that requires modulation and modification of host systems. HCMV induces an extensive rearrangement of the cellular endocytic recycling compartment into the site of virion maturation and egress: the cytoplasmic virion assembly compartment (cVAC). The HCMV cVAC is a distinguishing characteristic of infection, although studies have only been performed in traditional cell culture with limited observations in infectedhuman tissues. To study the cVAC, viral and cellular markers that are discrete to their respective compartments …