Virology Commons^™

The Role Of Fibroblast Growth Factor-9 In Influenza A Virus Pathogenesis, Bradley Edward Hiller

Arts & Sciences Electronic Theses and Dissertations

Influenza A virus (IAV) is a respiratory virus in the Orthomyxoviridae family which causes both seasonal epidemics and pandemics. IAV preferentially infects epithelial cells in the upper and lower respiratory tract, resulting in a range of disease severity from mild upper respiratory infections to potentially-lethal pneumonia. Ultimately, the severity of symptoms and complications from IAV infection depends on control of virus replication in the lungs, the inflammatory nature of the immune response, and the effectiveness of post-infection lung repair to regain pulmonary function. An arsenal of secreted proteins in the lung regulates these antiviral, inflammatory, and regenerative activities during infection, …