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In Vivo Influenza Virus-Inhibitory Effects Of The Cyclopentane Neuraminidase Inhibitor Rjw-270201, R W. Sidwell, D F. Smee, J H. Huffman, D L. Barnard, K W. Bailey, John D. Morrey, Y S. Babu
In Vivo Influenza Virus-Inhibitory Effects Of The Cyclopentane Neuraminidase Inhibitor Rjw-270201, R W. Sidwell, D F. Smee, J H. Huffman, D L. Barnard, K W. Bailey, John D. Morrey, Y S. Babu
John D. Morrey
The cyclopentane influenza virus neuraminidase inhibitor RWJ-270201 was evaluated against influenza A/NWS/33 (H1N1), A/Shangdong/09/93 (H3N2), A/Victoria/3/75 (H3N2), and B/Hong Kong/05/72 virus infections in mice. Treatment was by oral gavage twice daily for 5 days beginning 4 h pre-virus exposure. The influenza virus inhibitor oseltamivir was run in parallel, and ribavirin was included in studies with the A/Shangdong and B/Hong Kong viruses. RWJ-270201 was inhibitory to all infections using doses as low as 1 mg/kg/day. Oseltamivir was generally up to 10-fold less effective than RWJ-270201. Ribavirin was also inhibitory but was less tolerated by the mice at the 75-mg/kg/day dose used. …