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Tissue-Specific Replication Of Friend And Moloney Murine Leukemia Viruses In Infected Mice, L H. Evans, John D. Morrey
Tissue-Specific Replication Of Friend And Moloney Murine Leukemia Viruses In Infected Mice, L H. Evans, John D. Morrey
John D. Morrey
We have studied the replication of ecotropic murine leukemia viruses (MuLV) in the spleens and thymuses of mice infected with the lymphocytic leukemia-inducing virus Moloney MuLV (M-MuLV), with the erythroleukemia-inducing virus Friend MuLV (F-MuLV), or with in vitro-constructed recombinants between these viruses in which the long terminal repeat (LTR) sequences have been exchanged. At 1 week after infection both the parents and the LTR recombinants replicated predominantly in the spleens with only low levels of replication in the thymus. At 2 weeks after infection, the patterns of replication in the spleens and thymuses were strongly influenced by the type of …