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Full-Text Articles in Virology
Key Virus-Host Interactions Required For Arenavirus Particle Assembly And Release, Christopher Michael Ziegler
Key Virus-Host Interactions Required For Arenavirus Particle Assembly And Release, Christopher Michael Ziegler
Graduate College Dissertations and Theses
Viruses are infectious agents that must infect the cells of living organisms in order to reproduce. They have relatively simple genomes which encode few proteins but can compensate for their simplicity by hijacking components of their cellular hosts. Arenaviruses, a family of zoonotic viruses carried by rodents, encode only 4 proteins. One of these proteins, Z, is responsible for several functions during the virus life cycle including driving the formation and release of new virus particles at the plasma membrane of infected cells. Relatively little is known about how this viral protein is regulated or the complement of host proteins …
Determining The Role Of The Ergic-53 Cargo Receptor Complex In Arenavirus Propagation, Joseph P. Klaus
Determining The Role Of The Ergic-53 Cargo Receptor Complex In Arenavirus Propagation, Joseph P. Klaus
Graduate College Dissertations and Theses
Arenaviruses and hantaviruses are human pathogens that cause significant morbidity and mortality. The current lack of vaccines and treatment options for these viruses is a global concern. Despite producing only 4 proteins, these viruses are able to maintain a persistent and asymptomatic infection in wild rodents while being continuously shed into the environment. In humans, these viruses cause a spectrum of diseases ranging from aseptic meningitis to severe hemorrhagic fever syndromes. Little is known about how arenavirus and hantavirus proteins engage and interact with the human proteome during the complex process of viral biogenesis, or how the interactions with human …