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Full-Text Articles in Virology
Chemokines And Peptides That Promote And Inhibit Cmv Entry, Elisabeth Anne Pitt
Chemokines And Peptides That Promote And Inhibit Cmv Entry, Elisabeth Anne Pitt
Masters Theses
Human cytomegalovirus (HCMV) causes morbidity and mortality in congenitally infected newborns, transplant recipients, and AIDS patients. Currently, there is no approved CMV vaccine to address these issues. In an effort to develop an alternative treatment to CMV we tested our hypothesis that heparan sulfate binding D-peptides would be effective against multiple HCMV strains in vitro and it would be effective in vivo against murine CMV (MCMV) (Chapter 1). We show that the D-peptide is able to reduce CMV infection in vitro and in vivo. Another approach to combating CMV infections is to neutralize pathogenic factors that contribute to CMV …
Cmv Chemokines And Co-Infection: A Dissemination Plot That Peptides Can Foil, Pranay Dogra
Cmv Chemokines And Co-Infection: A Dissemination Plot That Peptides Can Foil, Pranay Dogra
Doctoral Dissertations
Human Cytomegalovirus (HCMV) is the leading cause of both non-hereditary mental retardation and hearing loss, and CMV infection/reactivation causes serious complications in transplant and immune compromised patients. Due to these issues, development of a CMV vaccine and/or therapeutics is required. To achieve this goal, it is necessary to gain a better understanding of CMV pathogenesis. Because of its coevolution with humans, HCMV has evolved genes with homology to human immune modulatory genes. Several of these genes help CMV establish a successful and lifelong infection within the host. An example is the viral CXC chemokine homolog UL146 gene (vCXCL-1). UL146 varies …