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Full-Text Articles in Virology
Uneven Distribution Of Mhc Class Ii Epitopes Within The Influenza Virus, Sherry R. Crowe, Shannon C. Miller, Pamela S. Adams, Richard Dutton, Allen G. Harmsen, Frances E. Lund, Troy D. Randall, Deborah M. Brown, Susan Swain, David L. Woodland
Uneven Distribution Of Mhc Class Ii Epitopes Within The Influenza Virus, Sherry R. Crowe, Shannon C. Miller, Pamela S. Adams, Richard Dutton, Allen G. Harmsen, Frances E. Lund, Troy D. Randall, Deborah M. Brown, Susan Swain, David L. Woodland
Nebraska Center for Virology: Faculty Publications
The identification of T cell epitopes is crucial for the understanding of the host immune response during infection. While much is known about the MHC class I-restricted response following influenza virus infection of C57BL/6 mice, with over 16 CD8 epitopes identified to date, less is known about the MHC class II-restricted response. Currently, only a few I-Ab-restricted T helper epitopes have been identified. Therefore, several important questions remain about how many class II epitopes exist in this system and whether these epitopes are evenly distributed within the most abundant viral proteins. In order to address these questions, we …