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Full-Text Articles in Virology
The Role Of Hypoxia Inducible Factor-1 Alpha (Hif-1⍺) In Human Coronavirus Oc43 Infection, Olivia Faith Riffey
The Role Of Hypoxia Inducible Factor-1 Alpha (Hif-1⍺) In Human Coronavirus Oc43 Infection, Olivia Faith Riffey
Masters Theses
The importance of altering host cell metabolism for promoting infection and propagation of coronaviruses highlights the intricate play between viruses and the cells they infect (1). Upregulation of the glycolytic pathway in host cells infected with coronaviruses was observed in single-cell RNAseq, although the mechanism(s) that mediate this effect are still being investigated(2). Hypoxia-inducible factor-1 alpha (HIF-1⍺) is a transcription factor that regulates many glycolytic enzymes. Recent studies have identified SARS-CoV-2 upregulation of HIF-1⍺, which suggests it may have an important role in virus production (3, 4). However, the exact role and physiological relevance of HIF-1⍺ during viral infection is …
Elucidating The Impact Of Roseophage On Roseobacter Metabolism And Marine Nutrient Cycles, Nana Yaw Darko Ankrah
Elucidating The Impact Of Roseophage On Roseobacter Metabolism And Marine Nutrient Cycles, Nana Yaw Darko Ankrah
Doctoral Dissertations
As the most abundant biological entities in marine environments, viruses are an important component of marine food webs. The activity of viruses contributes significantly to the mortality of marine microorganisms, ultimately influencing biological function and chemical composition of aquatic systems by impacting species composition and flow of carbon, nitrogen and other nutrients. Despite the growing recognition that viral activity contributes to marine biogeochemical cycles, the extent to which virus infection reshapes host metabolism and the effect of this alteration on the composition of host lysate remains poorly understood. Additionally, the degree to which natural bacterioplankton communities metabolise the released lysate …