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Full-Text Articles in Virology
The Role Of Human Ubc9 During The Human Immunodeficiency Virus Replication Cycle, Christopher R. Bohl
The Role Of Human Ubc9 During The Human Immunodeficiency Virus Replication Cycle, Christopher R. Bohl
School of Biological Sciences: Dissertations, Theses, and Student Research
Human immunodeficiency virus type 1 (HIV-1) is a retrovirus and the causative agent of the acquired immune deficiency syndrome (AIDS) pandemic. The retrovirus replication cycle is divided into early infectious events, which involve the infection and integration of the viral DNA into target cell chromosomes; and late events, which involve the expression of viral genes and assembly of infectious virions. To complete the replication cycle, HIV-1 utilizes various cellular pathways.
We identified the Ubc9 E2 SUMO conjugating enzyme as a HIV-1 Gag interaction partner. When this interaction was disrupted in HIV-1 producer cells by Ubc9 siRNA, the virus that was …