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Full-Text Articles in Virology
Characterization Of Binding And Fusion Efficiencies Mediated By The V1-V5 Env Derived From Transmitted And Non-Transmitted Viruses Isolated From A Perinatal Transmission Cohort From Zambia, Mackenzie Waltke
School of Biological Sciences: Dissertations, Theses, and Student Research
Human Immunodeficiency Virus Type 1 (HIV-1) is the etiological agent of acquired immunodeficiency syndrome (AIDS), which affects over 34 million people worldwide. In sub-Saharan Africa where access to antiretroviral therapies (ART) is limited, mother-to-child transmission (MTCT) rates remain high and represent a major concern in the global HIV/AIDS epidemic. Little is known about the biological properties of viruses that are transmitted perinatally, including how the biological functions of envelope (Env) influence transmissibility. Previously, transmitted viruses were found to have an advantage in replicative fitness mediated by Env V1-V5. In this study viruses derived from transmitting mother infant pairs (MIPs) were …