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Analysis Of Human Papillomavirus Capsid Proteins: Insights Into Capsid Assembly, Willie A. Hughes
Analysis Of Human Papillomavirus Capsid Proteins: Insights Into Capsid Assembly, Willie A. Hughes
School of Biological Sciences: Dissertations, Theses, and Student Research
Abstract:
Papillomaviruses (PVs) are double stranded (ds)-DNA viruses (~8-kbp), which infect mucosal and cutaneous epithelial cells from various mammalian species, causing tumors in both epithelial cell-types. During the late-phase, the capsid proteins (L1 and L2), are expressed to encapsidate the viral genome generating infectious virion particles required for PV. Natural PV infections produce morphologically homogenous progeny virions 55-nm in diameter. Transient transfection systems allow individual expression of the capsid proteins, which are able to produce low-levels of infectious virion-like particles (VLPs) and non-infectious VLPs that have the capacity to resemble and function as wild-type virions.
Results: The research herein …