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Herpes Simplex Virus Type 1 : Interactions With The Cellular Proteasome And Microrna Pathways, Daniel Joseph Munson
Herpes Simplex Virus Type 1 : Interactions With The Cellular Proteasome And Microrna Pathways, Daniel Joseph Munson
Legacy Theses & Dissertations (2009 - 2024)
Herpes Simplex Virus Type 1 (HSV-1) is a human pathogen that is estimated to have infected 60-80% of the population worldwide, causing oral lesions, encephalitis, and blindness. Infection results in life-long latency of the virus, with periods of reactivation and symptomatic disease. Early in infection, HSV-1 induces the formation of replication compartments and VICE (virus induced chaperone enriched) domains within the nucleus. Adjacent to VICE domains, we observed foci which contained Mss1, a cellular protein normally associated with the proteasome. Mss1 belongs to the AAA-ATPase family of proteins, which have been shown to function in DNA repair, transcription, translation, and …