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Full-Text Articles in Virology
Mechanisms Of Adenovirus Membrane Permeabilization, Oana Maier
Mechanisms Of Adenovirus Membrane Permeabilization, Oana Maier
Dissertations
For a successful infection to occur, a virus must first penetrate host cell membranes to access intracellular sites of viral replication. Currently the mechanism through which adenovirus, a non-enveloped, dsDNA virus, disrupts the endosomal membrane during cell entry is not well characterized.
Recent studies suggest that adenovirus protein VI, which is released from the interior of the capsid during cell entry, has all of the in vitro membrane lytic activity of the virion. We found that protein VI binds membranes via an amino-terminal 80 residue α-helical domain. Critical to this interaction are conserved hydrophobic and basic lysine residues within this …
Cofactors In Coronavirus Entry, Ana Shulla
Cofactors In Coronavirus Entry, Ana Shulla
Dissertations
Viruses have evolved complex ways to penetrate host barriers and cause disease. One of the most important barriers the virus has to cross is the cellular membrane. Enveloped viruses accomplish this task by viral glycoprotein-mediated binding to host cells and fusion of virus and host cell membranes. For the coronaviruses, viral spike (S) proteins execute these cell entry functions. In my dissertation research I focused on understanding the coronavirus spike proteins as well as other cofactors required for S-mediated entry into cells.
The S proteins are set apart from other viral and cellular membrane fusion proteins by their extensively palmitoylated …