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Full-Text Articles in Virology

A Structural And Functional Comparison Of Human Immunodeficiency Virus Type 1 Nucleocapsid Protein (Ncp7) And Other Retroviral Nucleocapsid Proteins, Christopher Richard Cavender Jan 2014

A Structural And Functional Comparison Of Human Immunodeficiency Virus Type 1 Nucleocapsid Protein (Ncp7) And Other Retroviral Nucleocapsid Proteins, Christopher Richard Cavender

Legacy Theses & Dissertations (2009 - 2024)

Human immunodeficiency virus type 1 (HIV-1) is a retrovirus belonging to the lentivirus genus of the orthoretrovirinae family. HIV-1 is widely known for causing acquired immunodeficiency syndrome (AIDS) in humans and being responsible for 1.8 million deaths due to AIDS associated illnesses in 201016.


Ribavirin-Resistant St. Louis Encephalitis Virus Populations Display Phenotypic And Genotypic Characteristics Of High-Fidelity Rna Polymerase Variants, Sara B. Griesemer Jan 2014

Ribavirin-Resistant St. Louis Encephalitis Virus Populations Display Phenotypic And Genotypic Characteristics Of High-Fidelity Rna Polymerase Variants, Sara B. Griesemer

Legacy Theses & Dissertations (2009 - 2024)

St. Louis encephalitis virus (SLEV) is mosquito-borne member of the family Flaviviridae, genus Flavivirus that is closely related to West Nile virus (WNV). Both viruses have potential to cause neuroinvasive disease in humans, and currently there is no vaccine or approved antiviral therapy. SLEV is maintained in nature through transmission between mosquitoes and birds, with humans acting as dead-end hosts. Despite their genetic and antigenic similarities, WNV and SLEV display different characteristics. WNV is known as a "generalist"; it is geographically widespread and can infect a wide variety of hosts, causing over 37,000 human cases in 48 U.S. states since …