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Full-Text Articles in Virology
Vitro Bacteriophage Treatment For A Staphylococcus Aureus And Pseudomonas Aeruginosa Co-Culture, Alexis Perry
Vitro Bacteriophage Treatment For A Staphylococcus Aureus And Pseudomonas Aeruginosa Co-Culture, Alexis Perry
Arkansas Women in STEM Conference
Recent studies show that up 27-36% of all infections are polymicrobial, involving more than one bacteria species. In all categories, polymicrobial infections are often more virulent and harmful to the patient. Since different types of bacteria can communicate with each other through quorum-sensing when in the presence of each other, they can display different genomic characteristics. Further research into polymicrobial infections needs to be done because these changing characteristics can prevent treatment from working, such as antibiotics or bacteriophage therapy. This experiment focused on the co-culture between the two bacteria, Pseudomonas aeruginosa and Staphylococcus aureus, which can be found co-existing …
Insights Into Viral Genome Function Through Comparative Structural Analysis, Lydia Phillips
Insights Into Viral Genome Function Through Comparative Structural Analysis, Lydia Phillips
UNO Student Research and Creative Activity Fair
Enteroviruses are single stranded RNA viruses which have caused many public health concerns, particularly in children. These viruses are responsible for polio, hand, foot, and mouth disease, many polio-like neurological diseases, and the common cold. The enterovirus called Coxsackievirus B3 (CVB3), a close relative to poliovirus, has been shown responsible for severe human disease, including pancreatitis, myocarditis, and type 1 diabetes. A unique advantage of studying CVB3 is the existence of a naturally occurring strain (CVB3/GA) which displays no known pathogenicity. Earlier comparative genomic studies have shown that the primary difference between avirulent CVB3/GA and the virulent strains of CVB3 …
The Us27 Protein Of Human Cytomegalovirus Enhances Signaling By Human Chemokine Receptor Cxcr4, Kathleen Arnolds, Juliet V. Spencer
The Us27 Protein Of Human Cytomegalovirus Enhances Signaling By Human Chemokine Receptor Cxcr4, Kathleen Arnolds, Juliet V. Spencer
Creative Activity and Research Day - CARD
Human cytomegalovirus (HCMV) is a prevalent pathogen that causes little disease except in immune-compromised hosts. HCMV establishes life-long latency by manipulating host immune responses. We have found that the US27 protein profoundly alters the activity of host chemokine receptor CXCR4. Cells expressing US27 and CXCR4 exhibited greater migration and calcium signaling than cells expressing CXCR4 alone. The mechanism for this enhanced signaling appears to be increased expression of CXCR4, and we are continuing to investigate how US27 causes up-regulation of CXCR4. This work is expected to clarify the role of US27 in immune evasion and provide insights into treatment strategies.