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Articles 1 - 11 of 11
Full-Text Articles in Virology
An Ecological Perspective Of American Rodent-Borne Orthohantavirus Surveillance, Nathaniel Mull
An Ecological Perspective Of American Rodent-Borne Orthohantavirus Surveillance, Nathaniel Mull
Graduate Theses and Dissertations
Orthohantaviruses are a global group of viruses found primarily in rodents, though several viruses have also been found in shrews and moles. Many rodent-borne orthohantaviruses are capable of causing one of several diseases in humans, and the mortality associated with these diseases ranges from < 0.1% - 50% depending on the specific etiological virus. In North and South America, orthohantavirus research was ignited by an outbreak of severe disease in the Four Corners region of the United States in 1993. However, despite the discovery of over 20 orthohantaviruses in the Americas, our understanding of orthohantavirus ecology and virus-host dynamics in this region is still limited, and orthohantavirus surveillance is generally restricted in scope to select regions and small portions of host distributional ranges. In Chapter I, I present a literature review on the current understanding of American rodent-borne orthohantavirus ecology. This review focused on under-studied orthohantaviruses, addressing gaps in knowledge by extrapolating information from well-studied orthohantaviruses, general rodent ecology, and occassionally from Eurasian orthohantavirus-host ecology. There were several key conclusions generated from this review that warrant further research: 1) the large number of putative orthohantaviruses and gaps in orthohantavirus evolution necessitate further surveillance and characterization, 2) orthohantavirus traits differ and are more generalizable based on host taxonomy rather than geography, and 3) orthohantavirus host species are disproportionately found in grasslands and disturbed habitats. In Chapter II, I present a prioritized list of rodent species to target for orthohantavirus surveillance based on predictive modeling using machine learning. Probable orthohantavirus hosts were predicted based on traits of known orthohantavirus hosts using two different types of evidence: RT-PCR and virus isolation. Predicted host distributions were also mapped to identify geographic hotspots to spatially guide future surveillance efforts. In Chapter III, I present a framework for understanding and predicting orthohantavirus traits based on reservoir host phylogeny, as opposed to the traditional geographic dichotomy used to group orthohantaviruses. This framework establishes three distinct orthohantavirus groups: murid-borne orthohantaviruses, arvicoline-borne orthohantaviruses, and non-arvicoline cricetid-borne orthohantaviruses, which differ in several key traits, including the human disease they cause, transmission routes, and virus-host fidelity. In Chapter IV, I compare rodent communities and orthohantavirus prevalence among grassland management regimes. Sites that were periodically burned had high rodent diversity and a high proportion of grassland species. However, rodent seroprevalence for orthohantavirus was also highest in burned sites, representing a trade-off in habitat management outcomes. The high seroprevalence in burned sites is likely due to the robust populations supported by the high quality habitat resulting from prescribed burning. In Chapters V and VI, I describe Ozark virus and Sager Creek virus, two novel orthohantaviruses discovered from specimens collected during Chapter IV. Both chapters report full genome sequences of the respective viruses and compare both nucleotide and protein phylogenies with related orthohantaviruses. Additionally in Chapter VI, I support the genetic analyses with molecular and ecological characterizations, including seasonal fluctuations in host abundance, correlates of prevalence, evidence of virus shedding, and information on host cell susceptibility to Sager Creek virus.
Odd Bedfellows & Marriage Of Necessity: Public Health And Politics In American Federalism, Gabriella Victoria Chianese
Odd Bedfellows & Marriage Of Necessity: Public Health And Politics In American Federalism, Gabriella Victoria Chianese
Honors Theses and Capstones
In the wake of the coronavirus disease 2019 (COVID-19) pandemic, while the public disagrees over mask mandates, required vaccinations, and social distancing, it seems like one common sentiment exists – a distaste for the odd bedfellows of politics and public health. There are those who cry for the compartmentalization of the science of public health and the art of politics to rectify this situation. In the wake of so much confusion and chaos, it is not unjustified to demand the depoliticization of public health; however, this response is unrealistic given the modern political climate, demonstrates a narrow understanding of the …
The Persistence Of Human Norovirus Surrogate In Leafy Greens Production System, Wenjun Deng
The Persistence Of Human Norovirus Surrogate In Leafy Greens Production System, Wenjun Deng
Graduate Theses and Dissertations
Since mostly consumed raw, foodborne pathogen contamination of leafy greens has led to a large number of foodborne disease outbreaks and illnesses each year in the United States. Human noroviruses (hNoV) are the most common viral pathogen transmitted by leafy greens. In this dissertation, the persistence of the hNoV surrogate Tulane virus (TV) on pre-harvest lettuce and microgreens was investigated. Lettuces are the most studied leafy green model, while previous hNoV research has mainly focused on the post-harvest stage of production. Here, pre-harvest hydroponically grown lettuce were used to determine TV persistence on leafy greens. After inoculation on leaves at …
Global Analysis Of High Cited Papers On “Impact Of Covid-19 On Mental Health” During 2020-21, Ghouse Modin Nabeesab Mamdapur Mr., Brij Mohan Gupta Dr., Sandeep Grover Dr.
Global Analysis Of High Cited Papers On “Impact Of Covid-19 On Mental Health” During 2020-21, Ghouse Modin Nabeesab Mamdapur Mr., Brij Mohan Gupta Dr., Sandeep Grover Dr.
Library Philosophy and Practice (e-journal)
A bibliometric analysis based on 160 highly cited papers extracted from the Scopus international database was carried out to provide insights into literature characteristics and publication performances of various participating actors on “Impact of COVID-19 on Mental Health”. Quantitative and qualitative Indicators were applied to measure the productivity and citation impact of most productive participating countries, organizations, authors, journals and significant keywords and to visualise and measure collaborative interaction among them using VOSviewer software. Results obtained from this study can provide valuable information for researchers and policy-makers to identify present and future hotspots in research on “Impact of COVID-19 on …
Psychological Impact Of Novel Coronavirus Covid-19 Across The Globe-A Review, Sadaf Shaheen, Iram Asim, Rida Zainab, Humaira Yasmeen
Psychological Impact Of Novel Coronavirus Covid-19 Across The Globe-A Review, Sadaf Shaheen, Iram Asim, Rida Zainab, Humaira Yasmeen
Journal of Bioresource Management
The recent outbreaks of novel coronavirus disease have unprecedent impact on mental health of patients, front-line healthcare workers and local population. However, the impact is not fully documented. This review explores stress-driven factors, stress-vulnerable groups and stress management interventions. Repetitive exposure to mass media and inappropriate health protective measures has heightened stress responses. Fear of not getting recovered from COVID-19 and disaffection has profound impact of infected individuals and their families. They may experience fear, anxiety, anger, sleep deprives and anorexia which may weakens their immune system thus making them vulnerable to COVID-19. The COVID-19 pandemic has underscored potential gaps …
Mucormycosis (Black Fungus) Maiming Covid Patients: Scientometrics Analysis Through Prism Of Biblioshiny, Sivankalai S, K Sivasekaran
Mucormycosis (Black Fungus) Maiming Covid Patients: Scientometrics Analysis Through Prism Of Biblioshiny, Sivankalai S, K Sivasekaran
Library Philosophy and Practice (e-journal)
This study analyses the global level outlook of research publications on Mucormycosis output between the period of 1923 to 2021 (May) on different limitations including contribution of authors, communication channel, publications on Institutions, countries, Journals, cited articles and mode of languages. 4451 data was downloaded from core collection of Web of Science bibliographic database using the search term ‘Mucormycosis’ and limited the publications 1900 to 2021, first publication was started in 1923 onwards. 3798 institutions and 8562 different disciplines contributed and 2808 records are in Articles. 4451 records published by 17320 authors and 23552 collaborated authors, documents per author are …
A Review Of Human Immunodeficiency Virus, Sophie Silver
A Review Of Human Immunodeficiency Virus, Sophie Silver
Senior Honors Theses
Human immunodeficiency virus, also referred to as HIV, is a devastating virus which has infected millions. Characterized as a retrovirus, HIV has an RNA genome, which is reverse transcribed into DNA upon entry into the host cell. HIV primarily affects CD4+ T cells and is diagnosed by the significant reduction of CD4+ T cells. While no cure has been discovered yet, antiretroviral therapy (ART) has been demonstrated as an effective treatment option. In the progression of HIV, additional HIV-associated diseases may arise, including HIV-associated psoriasis and sensory neuropathy. In addition to the use of ART, clinicians often prescribe …
Identification And Characterisation Of Novel Phages Of Pectobacterium And Erwinia, Colin Buttimer
Identification And Characterisation Of Novel Phages Of Pectobacterium And Erwinia, Colin Buttimer
PhDs
Losses in crop yields due to disease need to be reduced to meet increasing global food demands associated with growth in the human population. There is a well-recognised need to develop new environmentally-friendly control strategies to combat bacterial crop diseases. There are several crop diseases for which no effective bactericidal agents are currently available, such as potato blackleg and soft rot disease caused by Pectobacterium atrosepticum and other members of soft rot Enterobacteriaceae (Czajkowski et al., 2011). Furthermore, current control measures involving the use of traditional chemicals or antibiotics are losing their efficacy due to the natural development of bacterial …
Reviews Of Science For Science Librarians: The Challenge Of The Zika Virus: An Emerging Arbovirus Disease, Frances A. Delwiche
Reviews Of Science For Science Librarians: The Challenge Of The Zika Virus: An Emerging Arbovirus Disease, Frances A. Delwiche
University Libraries Faculty and Staff Publications
First identified in Uganda in 1947, the Zika virus simmered quietly for sixty years, occasionally causing a mild dengue-like illness across parts of central Africa and equatorial Asia. However, since 2007, three large outbreaks have occurred: first in Micronesia, then in French Polynesia in 2013-2014, and as an epidemic involving Mexico, the Caribbean, and Central and South America in 2015-2016. This paper reviews the virology of the Zika virus, its modes of transmission, symptoms of Zika Virus Disease, the association of Zika infections with microcephaly and Guillain-Barre Syndrome, prevention of Zika infections, and ongoing efforts to develop a vaccine.
Loss Of Cell Surface Agal During Catarrhine Evolution: Possible Implications For The Evolution Of Resistance To Viral Infections And For Oligocene Lineage Divergence, Idalia Aracely Rodriguez
Loss Of Cell Surface Agal During Catarrhine Evolution: Possible Implications For The Evolution Of Resistance To Viral Infections And For Oligocene Lineage Divergence, Idalia Aracely Rodriguez
Doctoral Dissertations
The divergence of the two superfamilies belonging to the Infraorder Catarrhini –Cercopithecoidea (Old World monkeys) and Hominoidea (apes, including humans) – is generally assumed to have occurred during the Oligocene, between 38 and 20 million years ago. Genetic studies indicate that this time period was one of active genetic evolution under strong purifying selection for catarrhine primates. This includes selective pressures on the glycoprotein galactosyltransferase 1 (GGTA1) gene and subsequent inactivation “clocked” at approximately 28 ma, possibly prior to the Cercopithecoidea/Hominoidea split. The GGTA1 gene codes for an a1,3 galactosyltransferase (GT) enzyme that synthesizes a terminal disaccharide, …
Prenatal Stress, Depression, And Herpes Viral Titers, Pao-Chu Hsu
Prenatal Stress, Depression, And Herpes Viral Titers, Pao-Chu Hsu
USF Tampa Graduate Theses and Dissertations
Recent studies suggest that some cases of prenatal depression may be associated with reactivation of latent infections of the herpesvirus family. The possible relationships among stress, prenatal depression, and herpes viral reactivation in pregnancy are understudied and the molecular pathways such as the neuroimmune biogenic amine pathway are unidentified. Chronic stress shifts the T helper-1 cell (Th1) cytokine profile to a Th2 profile, which favors virus induced pathogenesis and survival. Pregnancy is also associated with a similar Th2 dominance. In non-pregnant individuals, exposure to psychological or physical stress may be associated with latent herpes viral reactivation and could result in …