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Key Roles Of Sub-Cellular Membranes And Co-Chaperone In Tombusvirus Replication, Kai Xu
Key Roles Of Sub-Cellular Membranes And Co-Chaperone In Tombusvirus Replication, Kai Xu
Theses and Dissertations--Plant Pathology
Positive strand RNA viruses, inculding tombusviruses, are known to utilize cellular membranes to assemble their replicase complexes (VRCs). Two tombusviruses , Tomato bushy stunt virus (TBSV) and Carnation Italian ringspot virus (CIRV), replicate on different organellar membranes, peroxisomes or endoplasmic reticulum (ER) for TBSV and mitochodria outer membranes in case of CIRV. I showed that both TBSV and CIRV replicase proteins could assemble VRCs and replicate viral RNA on purified microsomes (ER) and mitochondria. Different efficiencies of assembly was shown determined by multiple domains on TBSV or CIRV replication proteins.
To study why VRC assembly could occur on an alternative …