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Investigation Of Bovine Herpesvirus 1 (Bhv-1) Encoded Infected Cell Protein 0 (Bicp0), Natasha N. Gaudreault
Investigation Of Bovine Herpesvirus 1 (Bhv-1) Encoded Infected Cell Protein 0 (Bicp0), Natasha N. Gaudreault
School of Biological Sciences: Dissertations, Theses, and Student Research
Bovine herpesvirus 1 (BHV-1) is a significant pathogen of cattle. Following acute infection, BHV-1 establishes a latent infection that persists for the life of the infected host. Stress induced factors cause the virus to reactivate from latency, resulting in virus transmission and transient immune suppression. BHV-1 encoded bICP0 is expressed early and constitutively throughout productive infection. bICP0 is critical for efficient viral replication, virulence, and reactivation in cattle because it stimulates viral transcription and interferes with innate immune responses. bICP0 potentially interacts with a variety of proteins to activate viral gene expression and inhibit innate antiviral defenses. bICP0 localizes to …