Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- AP-1 component dosage in memory CD8 T cell subsets (1)
- Adult (1)
- Anti-viral (1)
- Antigen Presentation (1)
- Behavior (1)
-
- Brain (1)
- CD8 T cells (1)
- COVID-19 (1)
- Gammaherpesvirus-specific CD8 T cell reactivation for immunotherapy (1)
- Gammaherpesvirus-specific tissue-resident memory CD8 T cells (1)
- Gammaherpesviruses (1)
- Immune (1)
- MHC II (1)
- Measles (1)
- Memory CD8 T cell differentiation (1)
- Neural stem cells (1)
- Neurogenesis (1)
- Phagocytosis (1)
- SARS-CoV-2 (1)
- Vesicular Trafficking (1)
- Virus (1)
- Zbtb20 (1)
Articles 1 - 3 of 3
Full-Text Articles in Virology
Neural Stem Cells: Age-Dependent Outcomes During Viral Infections In The Central Nervous System, Manisha N. Chandwani
Neural Stem Cells: Age-Dependent Outcomes During Viral Infections In The Central Nervous System, Manisha N. Chandwani
Electronic Theses and Dissertations
Viral infections in the central nervous system (CNS) are associated with neurodevelopmental and neurobehavioral deficits. The outcomes of viral infections can be driven by damage and death of neurons. Neural stem cells (NSCs) play key roles in neurodevelopment, repair, and physiological brain function. During a viral infection, NSC activity can disturbed by direct infection of NSCs by the virus or by anti-viral immune response. Here, we aimed to assess whether the anti-viral immune response can impact NSC activity during an immunocompetent response in the adult brain. We utilized a transgenic mouse model of Measles virus infection where only the CNS …
Regulation Of Mhc Ii Trafficking And Expression By Host And Viral Factors, Alex Lac
Regulation Of Mhc Ii Trafficking And Expression By Host And Viral Factors, Alex Lac
Electronic Thesis and Dissertation Repository
Antigen presentation by major histocompatibility complex class II (MHC II) to the adaptive immune system is crucial for mounting sterilizing immune responses. This central role has made antigen presentation a target for antagonism by many pathogens. Notably, infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) decrease MHC II expression in several immune cells. The mechanisms responsible for this suppression are unknown but involves either redirecting MHC II molecules away from the cell surface or inhibiting MHC II expression. To understand how pathogens manipulate intracellular MHC II trafficking, we first investigated the role of the Golgi trafficking regulator, ERC1, in …
Response And Molecular Control Of Cd8 T Cells During Infection And Cancer, Nicholas K. Preiss Dr.
Response And Molecular Control Of Cd8 T Cells During Infection And Cancer, Nicholas K. Preiss Dr.
Dartmouth College Ph.D Dissertations
CD8 T cells are potent immune effector cells capable of vast clonal expansion and clearance of infected or cancerous cells. After control of the pathogenic insult, CD8 T cells develop into quiescent, long-lived memory populations that are poised to mediate rapid protection upon reencounter with cognate antigen. These properties make control of CD8 T cell responses a highly desirable outcome of vaccine strategies and immunotherapy. Therefore, understanding how the effector function and memory differentiation of CD8 T cells are controlled at a molecular level is of great importance. In the context of infection with gammaherpesviruses (γHV), which form a latent …