Open Access. Powered by Scholars. Published by Universities.®
- Institution
- Keyword
-
- Adenovirus early gene (1)
- Biofilms | Pathogenic microorganisms | Anti-infective agents | Staphylococcal infections | Cross Infection -- Prevention & control (1)
- Biomedical (1)
- Chemistry, Medicine, Nanoscience (1)
- CroV (1)
-
- E1A (1)
- Early region 1A (1)
- Early region 2e (1)
- Early region 3 (1)
- Early region 4 (1)
- H2B-ub (1)
- H2K4me3 (1)
- H3K79me3 (1)
- HBre1 (1)
- HPTM (1)
- HPaf1 (1)
- Human adenovirus (1)
- Human metapneumovirus (HMPV) (1)
- ISG (1)
- Interferon (1)
- MCP (1)
- Minireplicon (1)
- NCLDV (1)
- Nanoparticles (1)
- Nucleocapsid (1)
- Phosphoprotein (1)
- RNA-dependent RNA polymerase (RdRp) (1)
- RNF40 (1)
- Supramolecular (1)
- Transcription (1)
- Publication
- Publication Type
Articles 1 - 5 of 5
Full-Text Articles in Virology
A Supramolecular Strategy To Assemble Multifunctional Viral Nanoparticles, Limin Chen, Xia Zhao, Yuan Lin, Yubin Huang, Qian Wang
A Supramolecular Strategy To Assemble Multifunctional Viral Nanoparticles, Limin Chen, Xia Zhao, Yuan Lin, Yubin Huang, Qian Wang
Faculty Publications
Using a one-pot approach driven by the supramolecular interaction between β-cyclodextrin and adamantyl moieties, multifunctional viral nanoparticles can be facilely formulated for biomedical applications.
Human Adenovirus E1a Binds And Retasks Cellular Hbre1, Blocking Interferon Signalling And Activating Virus Early Gene Transcription, Gregory J. Fonseca
Human Adenovirus E1a Binds And Retasks Cellular Hbre1, Blocking Interferon Signalling And Activating Virus Early Gene Transcription, Gregory J. Fonseca
Electronic Thesis and Dissertation Repository
Upon infection, human adenovirus (HAdV) must block interferon signaling and activate the expression of its early genes to reprogram the cellular environment to support virus replication. During the initial phase of infection, these processes are orchestrated by the first HAdV gene expressed during infection, early region 1A (E1A). E1A binds and appropriates components of the cellular transcriptional machinery to modulate cellular gene transcription and activate viral early genes transcription. We have identified hBre1/RNF20 as a novel target of E1A. hBre1 is an E3 ubiquitin ligase which acts with the Ube2b E2 conjugase and accessory factors RNF40 and WAC1 to monoubiquitinate …
Critical Events In Human Metapneumovirus Infection: From Entry To Egress, Brent A. Hackett
Critical Events In Human Metapneumovirus Infection: From Entry To Egress, Brent A. Hackett
Theses and Dissertations--Molecular and Cellular Biochemistry
Human metapneumovirus (HMPV) is a respiratory pathogen in Paramyxovirus family that demonstrates extremely high morbidity in the population, with most individuals having been infected by the age of five. Despite the prevalence of this negative-sense RNA virus in the population for decades, it was only identified in 2001. As such, there is currently no specific treatment for HMPV and the potentially severe consequences of infection for elderly and immunocompromised individuals and particularly infants make development of antivirals targeting HMPV of high significance. HMPV constitutes a quarter of all respiratory hospitalizations among infants, placing it second only to RSV, in addition …
Exploitation Of The Bacteriophage-Derived Peptidase Chapk, Pierre-Mehdi Hadbi
Exploitation Of The Bacteriophage-Derived Peptidase Chapk, Pierre-Mehdi Hadbi
Theses
This project investigated an anti-staphylococcal bacteriophage-derived peptidoglycan hydrolase enzyme, namely a cysteine-histidine amydohydrolase/peptidase (CHAPk). The study focused firstly on optimizing the production of recombinant CHAPk, which was previously cloned in an E. coli expression system, and sets out the resulting optimal Standard Operating Procedures (SOPs) for production, purification and determination of concentration and activity of the resulting protein stock. A typical yield resulting from the investigation was 300pg of CHAPk from one litre of E.coli culture. The activity of the purified enzyme was typically in the region of 190U nmol ’. Secondly, the project investigated …
Expression And Characterization Of The Major Capsid Protein (Mcp) Of A Giant Marine Virus: Cafeteria Roenbergensis Virus, Sayan Chakraborty
Expression And Characterization Of The Major Capsid Protein (Mcp) Of A Giant Marine Virus: Cafeteria Roenbergensis Virus, Sayan Chakraborty
Open Access Theses & Dissertations
The oceans play significant roles in maintaining the climate on Earth and providing nutrients to the whole biosphere. Oceanic microbes produce approximately half of the Earth's oxygen. It has been shown that the populations of microbial communities in oceans are largely regulated by viral infection and thus affect the marine ecosystem. Cafeteria roenbergensis Virus (CroV) is a giant marine virus with a linear, double stranded, and AT-rich DNA genome. The genome of CroV has a size of 744kb and encodes for 544 predicted genes. CroV derived its name from its host, a unicellular marine zooplankton Cafeteria roenbergensis (Cro) that is …