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Full-Text Articles in Pathogenic Microbiology
Blastomyces: Why Be Dimorphic?, Dennis J. Baumgardner
Blastomyces: Why Be Dimorphic?, Dennis J. Baumgardner
Dennis J. Baumgardner, MD
In introducing the infectious disease focus for this edition of the Journal of Patient-Centered Research and Reviews, the author describes the unsolved mysteries surrounding the dimorphic fungus Blastomyces and the related pathogenesis of pulmonary blastomycosis.
Characterization Of The Ato Gene Family In Alternative Carbon Metabolism, Heather A. Danhof
Characterization Of The Ato Gene Family In Alternative Carbon Metabolism, Heather A. Danhof
Dissertations & Theses (Open Access)
As a commensal colonizer and opportunistic pathogen, Candida albicans is the most clinically important human associated fungus. Systemic infection carries an unacceptably high mortality rate of ~40% in the growing population of immunocompromised individuals. Macrophages are important innate immune cells that limit the niches in the human body in which C. albicans can persist through phagocytic removal. However, following phagocytosis C. albicans readily escapes from the immune cell by differentiating into filamentous hyphae, a process that should be inhibited in the normally acidic phagolysosome. We have shown that C. albicans induces germination by neutralizing the phagolysosome. To better understand this …
Blastomyces: Why Be Dimorphic?, Dennis J. Baumgardner
Blastomyces: Why Be Dimorphic?, Dennis J. Baumgardner
Journal of Patient-Centered Research and Reviews
In introducing the infectious disease focus for this edition of the Journal of Patient-Centered Research and Reviews, the author describes the unsolved mysteries surrounding the dimorphic fungus Blastomyces and the related pathogenesis of pulmonary blastomycosis.