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Full-Text Articles in Pathogenic Microbiology
Algr Directly Controls Rsma In Pseudomonas Aeruginosa, Tyler Speaks
Algr Directly Controls Rsma In Pseudomonas Aeruginosa, Tyler Speaks
Electronic Theses and Dissertations
Pseudomonas aeruginosa is a bacterial pathogen that can infect any human tissue. The lungs of cystic fibrosis patients become chronically infected with Pseudomonas aeruginosa. Virulence factor gene expression is under elaborate regulatory control that remains poorly characterized. Understanding the regulatory hierarchy involved during infection is essential for identifying novel drug targets. RsmA is a post-transcriptional regulatory protein that controls expression of several virulence factors. Previous studies demonstrated alginate regulatory components AlgU and AlgR as regulators of rsmA expression. The aim of this study was to determine how AlgR controls rsmA expression. Western blot analysis of HA-tagged RsmA confirmed lower …
Characterization Of The Poxab Operon Encoding A Class D Carbapenemase In Pseudomonas Aeruginosa,, Diansy Zincke
Characterization Of The Poxab Operon Encoding A Class D Carbapenemase In Pseudomonas Aeruginosa,, Diansy Zincke
FIU Electronic Theses and Dissertations
Pseudomonas aeruginosa is a dreaded opportunistic pathogen that causes severe and often intractable infections in immunocompromised and critically ill patients. This bacterium is also the primary cause of fatal lung infections in patients with cystic fibrosis and a leading nosocomial pathogen responsible for nearly 10% of all hospital-acquired infections. P. aeruginosa is intrinsically recalcitrant to most classes of antibiotics and has the ability to acquire additional resistance during treatment. In particular, resistance to the widely used β-lactam antibiotics is frequently mediated by the expression of AmpC, a chromosomally encoded β-lactamase that is ubiquitously found in P. aeruginosa strains. This dissertation …