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Full-Text Articles in Pathogenic Microbiology
Metalloregulation Of Helicobacter Pylori Physiology And Pathogenesis, Kathryn P. Haley, Jennifer A. Gaddy
Metalloregulation Of Helicobacter Pylori Physiology And Pathogenesis, Kathryn P. Haley, Jennifer A. Gaddy
Peer Reviewed Articles
Helicobacter pylori is a Gram-negative spiral-shaped bacterium that colonizes over half of the world's population. Chronic H. pylori infection is associated with increased risk for numerous disease outcomes including gastritis, dysplasia, neoplasia, B-cell lymphoma of mucosal-associated lymphoid tissue (MALT lymphoma), and invasive adenocarcinoma. The complex interactions that occur between pathogen and host are dynamic and exquisitely regulated, and the relationship between H. pylori and its human host are no exception. To successfully colonize, and subsequently persist, within the human stomach H. pylori must temporally regulate numerous genes to ensure localization to the gastric lumen and coordinated expression of virulence factors …
Absence Of Soda Increases The Levels Of Oxidation Of Key Metabolic Determinants Of Borrelia Burgdorferi, Maria D. Esteve-Gassent, Trever C. Smith Ii, Christina M. Small, Derek P. Thomas, J Seshu
Absence Of Soda Increases The Levels Of Oxidation Of Key Metabolic Determinants Of Borrelia Burgdorferi, Maria D. Esteve-Gassent, Trever C. Smith Ii, Christina M. Small, Derek P. Thomas, J Seshu
Peer Reviewed Articles
Borrelia burgdorferi, the causative agent of Lyme disease, alters its gene expression in response to environmental signals unique to its tick vector or vertebrate hosts. B. burgdorferi carries one superoxide dismutase gene (sodA) capable of controlling intracellular superoxide levels. Previously, sodA was shown to be essential for infection of B. burgdorferi in the C3H/HeN model of Lyme disease. We employed two-dimensional electrophoresis (2-DE) and immunoblot analysis with antibodies specific to carbonylated proteins to identify targets that were differentially oxidized in the soluble fractions of the sodA mutant compared to its isogenic parental control strain following …
Helicobacter Pylori: Genomic Insight Into The Host-Pathogen Interaction, Kathryn P. Haley, Jennifer A. Gaddy
Helicobacter Pylori: Genomic Insight Into The Host-Pathogen Interaction, Kathryn P. Haley, Jennifer A. Gaddy
Peer Reviewed Articles
The advent of genomic analyses has revolutionized the study of human health. Infectious disease research in particular has experienced an explosion of bacterial genomic, transcriptomic, and proteomic data complementing the phenotypic methods employed in traditional bacteriology. Together, these techniques have revealed novel virulence determinants in numerous pathogens and have provided information for potential chemotherapeutics. The bacterial pathogen, Helicobacter pylori, has been recognized as a class 1 carcinogen and contributes to chronic inflammation within the gastric niche. Genomic analyses have uncovered remarkable coevolution between the human host and H. pylori. Perturbation of this coevolution results in dysregulation of the …