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Full-Text Articles in Pathogenic Microbiology
Pas Signaling Mechanisms In Aer And Aer2, Darysbel Garcia
Pas Signaling Mechanisms In Aer And Aer2, Darysbel Garcia
Loma Linda University Electronic Theses, Dissertations & Projects
PAS domains are widespread signal sensors that share a conserved three-dimensional αβ fold that consists of a central β-sheet flanked by several α- helices. The aerotaxis receptor Aer from Escherichia coli and the Aer2 chemoreceptor from Pseudomonas aeruginosa both contain PAS domains. Aer senses oxygen (O2) indirectly via an FAD cofactor bound to its PAS domain, while Aer2 directly binds O2 to its PAS b-type heme cofactor. The Aer and Aer2 PAS domains both interact with a signal transduction domain known as a HAMP domain. The PAS-HAMP arrangement differs between Aer and Aer2, with Aer- PAS residing adjacent to its …
Mechanisms Of Virulence Regulation In Porphyromonas Gingivalis W83, Elaine Ann-Marie Vanterpool
Mechanisms Of Virulence Regulation In Porphyromonas Gingivalis W83, Elaine Ann-Marie Vanterpool
Loma Linda University Electronic Theses, Dissertations & Projects
The expression of extracellular proteolytic activities is highly regulated in both prokaryotic and eukaryotic systems. This regulation can occur at multiple levels including expression of the protease genes, secretion, processing of an inactive secreted precursor to its active form and/or the posttranslational glycosylation of the proteins. These regulatory mechanisms are vital to ensure that expression is tightly controlled. Porphyromonas gingivalis has been associated with adult periodontitis and in the development of many systematic diseases. The major virulence factors of P. gingivalis, the gingipains, are responsible for pathogenesis including degradation of complement and immunoglobulin, inactivation of cytokines and their receptors, …
Effects Of Corticosteroids And Of Cyclosporin A On Trypanosoma Musculi In Mice And In Culture, Philip Stephen Schuyler
Effects Of Corticosteroids And Of Cyclosporin A On Trypanosoma Musculi In Mice And In Culture, Philip Stephen Schuyler
Loma Linda University Electronic Theses, Dissertations & Projects
The in vivo and in vitro effects of cyclosporin A and corticosteroids on Trypanosoma musculi were examined. Mice that received continuous administration of 6 mg/liter/day of dexamethasone in drinking water and 200 mg/kg hydrocortisone acetate as a single dose 24 hrs prior to injection with T. musculi had significantly higher and longer parasitemias, than controls. Body and spleen weights and B cell responsiveness were lower in test animals and there were some deaths. Mice injected with T. musculi that received 100 mg/kg/day cyclosporin A had longer, but not higher, parasitemias than controls. Corticosteroids appear to partially inactive antibody production (i.e. …
A Study Of Door Pulls On Isolation Carts In A General Hospital For Evidence Of Contamination, Mary Alice Harper
A Study Of Door Pulls On Isolation Carts In A General Hospital For Evidence Of Contamination, Mary Alice Harper
Loma Linda University Electronic Theses, Dissertations & Projects
The purpose of the study was to find out if isolation carts were serving as a means of cross infection. Literature pertaining to sources of possible contamination on hospital units written in the past five years were reviewed.
Using the descriptive survey as the method of study, effort was made to find out if isolation carts were a means of cross infection on the hospital unit. Two laboratory cultures were obtained from both door pulls on all isolation carts used by nursing units. This was done over a three month period from December 12, 1963 to March 11, 1964. The …