Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Pathogenic Microbiology
Stress Response Mechanisms Of Listeria Monocytogenes, Oindrila Paul
Stress Response Mechanisms Of Listeria Monocytogenes, Oindrila Paul
Dissertations
Listeria monocytogenes is a Gram-positive, facultative intracellular food-borne pathogen that causes the disease listeriosis. In order to establish an infection, L. monocytogenes must survive multiple stressors encountered within the gastrointestinal tract, including alterations in pH, bile, salt, and oxygen availability. This dissertation focused on understanding the stress response of L. monocytogenes to bile. Bile acts as a bactericidal agent by disrupting the membrane integrity and causing instability to macromolecules like DNA. Thus, a bacterium must be able to maintain its membrane architecture, composition and integrity.
Often times, bacteria will modulate their fatty acid composition in the membrane to cope with …