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Full-Text Articles in Pathogenic Microbiology
Defining Environmental Stresses That Activate The Rna Repair Operon In Salmonella Typhimurium, Caleb M. Gulledge
Defining Environmental Stresses That Activate The Rna Repair Operon In Salmonella Typhimurium, Caleb M. Gulledge
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Background
RNA polymerase holoenzyme (Eσ) mediates transcription in eubacteria, and is composed of five constant subunits (α2ββ’ω) and a variable sigma (σ) subunit that is responsible for promoter recognition and initiation of transcription. An alternative sigma factor in Salmonella Typhimurium, σ54 (also called RpoN), is mechanistically different than classical σ70-type sigmas, requiring a different promoter consensus sequence, an activator, and ATP hydrolysis. The Rtc RNA repair operon lies within the regulon of RpoN in S. Typhimurium, but has no known physiological function. Previous work characterized similar systems in archaea and humans, which were determined to …