Open Access. Powered by Scholars. Published by Universities.®
- Institution
- Keyword
-
- Microbiology (2)
- AIEC NC101 (1)
- Antibiotic tolerance (1)
- Biofilms (1)
- Cell wall (1)
-
- Crohn's Disease (1)
- Gene expression (1)
- Gene regulation (1)
- Genome comparison (1)
- Gut microbiome (1)
- Host-pathogen interactions (1)
- IL-10 KO Mouse Model (1)
- Infectious Diseases (1)
- Mycobacteria (1)
- Mycobacterium abscessus (1)
- Mycobacterium smegmatis (1)
- Mycobacterium tuberculosis (1)
- Mycology (1)
- PCR (1)
- Peptidoglycan (1)
- Persisters (1)
- Phosphorylation (1)
- Plant Pathology (1)
- Public Health (1)
- Ribosome Hibernation (1)
- Rickettsia (1)
- Stress response (1)
- Transcriptome analysis (1)
- Tuberculosis (1)
Articles 1 - 5 of 5
Full-Text Articles in Pathogenic Microbiology
The Molecular Detection Of Sphaerulina Vaccinii: A Leaf Spot Pathogen Of Lowbush Blueberry, Zoe Colwell
The Molecular Detection Of Sphaerulina Vaccinii: A Leaf Spot Pathogen Of Lowbush Blueberry, Zoe Colwell
Electronic Theses and Dissertations
Sphaerulina vaccinii is a fungal leaf spot pathogen of lowbush blueberry, Vaccinium angustifolium, causing Sphaerulina leaf spot. Infection by this pathogen results in symptoms of dark lesions on the leaves and stems in either of the crop cycle years. Severe infection by this pathogen is thought to result in decreased fruit retention and yield. As wild blueberries are central to Maine’s economy, reliable disease identification is essential for using suitable management strategies to control disease. Molecular-based methods for pathogen differentiation have been used efficiently to identify fungal pathogens in economically important crops. To develop a molecular-based method to identify …
Adherent-Invasive Escherichia Coli (Aiec) Promotes Mild Colitis In The C57bl/6 Il-10 Ko Mouse Model Of Crohn's Disease, Sarah Sm Zaw
Adherent-Invasive Escherichia Coli (Aiec) Promotes Mild Colitis In The C57bl/6 Il-10 Ko Mouse Model Of Crohn's Disease, Sarah Sm Zaw
Senior Theses
Crohn's disease (CD) is a chronic inflammatory bowel disease. Interleukin-10 knockout (IL-10 KO) mice are crucial in CD research. Adherent-invasive Escherichia coli (AIEC) is a subgroup of E. coli. In one study, IL-10 KO mice colonized with AIEC developed colitis in the distal colon compared to wild-type (WT) mice. I investigated how AIEC NC101 WT affects colitis severity in IL-10 KO mice of the C57BL/6 genetic background. Similar results in both genotypes would enhance mouse strain accessibility. Germ-free C57BL6 IL-10 KO mice were divided into groups: colonized with AIEC NC101 for 12, 15, or 18 weeks, or kept germ-free. Histopathological …
Managing Stress: A Study Of Stress Response Mechanisms In Mycobacteria, Augusto C. Hunt Serracin
Managing Stress: A Study Of Stress Response Mechanisms In Mycobacteria, Augusto C. Hunt Serracin
Biology Dissertations
Mycobacteria encompass many pathogenic species known to cause severe disease in humans. A well-known example is Mycobacterium tuberculosis (Mtb), the causative agent of the lung disease tuberculosis, which kills millions of humans worldwide yearly. Pathogenic mycobacteria like Mtb are challenging to treat because of their innate ability to adapt to environmental stress. Their unique cell physiology and conserved stress responses allow them to combat biological insults, regulate growth, and regulate genes involved in stress; all these responses increase tolerance to antibiotics. The current therapies to treat mycobacterial infections are lengthy and, at times, unsuccessful, partly due to antibiotic tolerance. A …
Characterization Of Host Cell Specific Interactions During Spotted Fever Group Rickettsiae Infection, Emerson Towey
Characterization Of Host Cell Specific Interactions During Spotted Fever Group Rickettsiae Infection, Emerson Towey
Graduate Theses, Dissertations, and Problem Reports
Vector-borne diseases have been increasing over the past few years due to changes in climate and disturbances in the vectors’ natural environment. To mitigate the risks of these diseases, it is necessary to understand pathogen biology and how it interacts with a host to cause disease. Here we focus our attention on the tick-borne pathogen, Rickettsia rickettsii. R. rickettsii is a member of the spotted fever group (SFG) Rickettsiae and is the etiological agent of Rocky Mountain spotted fever (RMSF), a fatal human disease that is lacking an effective vaccine. Members of the bacterial genus Rickettsia are obligate intracellular endoparasites …
Ribosome Hibernation Factor Induces Antibiotic Persisters Of Mycobacterium Tuberculosis In Neutrophil-Rich Lung Lesions, Jamie Corro
Electronic Theses & Dissertations (2024 - present)
Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis, is a prescient global health threat and the leading cause of death by an infectious agent. Treatment of Mtb infection involves administering 2-4 antibiotics for a minimum of 6 months. This extended drug regimen is required to target a subpopulation of persistent bacilli. As their name implies, these bacteria can “persist” by acquiring nonhereditary and transient antibiotic tolerance. Although the precise mechanism is unknown, it’s often attributed to slowing cellular growth and metabolic processes. During zinc deprivation, bacteria can remodel their ribosomes by replacing their zinc-binding paralogues containing the CXXC motif (C+) …