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Multiple Posttranscriptional Regulatory Features Control Expression Of Ethanolamine Utilization Genes In Enterococcus Faecalis, Kristina A. Fox
Multiple Posttranscriptional Regulatory Features Control Expression Of Ethanolamine Utilization Genes In Enterococcus Faecalis, Kristina A. Fox
Dissertations & Theses (Open Access)
Enterococcus faecalis is a Gram-positive bacterium that lives as a commensal organism in the mammalian gastrointestinal tract, but can behave as an opportunistic pathogen. Our lab discovered that mutation of the eutK gene attenuates virulence of E. faecalis in the C. elegans model host. eutK is part of the ethanolamine metabolic pathway which was previously unknown in E. faecalis. I discovered the presence of two unique posttranscriptional regulatory features that control expression of eut locus genes. The first feature I found is an AdoCBL riboswitch, a cis-acting RNA regulatory element that acts as a positive regulator of gene …