Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Bacteriology (4)
- Medicine and Health Sciences (3)
- Bacteria (2)
- Bacterial Infections and Mycoses (2)
- Diseases (2)
-
- Genetics and Genomics (2)
- Molecular Genetics (2)
- Organisms (2)
- Pathogenic Microbiology (2)
- Amino Acids, Peptides, and Proteins (1)
- Biochemistry, Biophysics, and Structural Biology (1)
- Biology (1)
- Chemicals and Drugs (1)
- Enzymes and Coenzymes (1)
- Epidemiology (1)
- Integrative Biology (1)
- Lipids (1)
- Molecular Biology (1)
- Public Health (1)
- Institution
Articles 1 - 6 of 6
Full-Text Articles in Microbial Physiology
Managing Stress: A Study Of Stress Response Mechanisms In Mycobacteria, Augusto C. Hunt Serracin
Managing Stress: A Study Of Stress Response Mechanisms In Mycobacteria, Augusto C. Hunt Serracin
Biology Dissertations - Archive
Mycobacteria encompass many pathogenic species known to cause severe disease in humans. A well-known example is Mycobacterium tuberculosis (Mtb), the causative agent of the lung disease tuberculosis, which kills millions of humans worldwide yearly. Pathogenic mycobacteria like Mtb are challenging to treat because of their innate ability to adapt to environmental stress. Their unique cell physiology and conserved stress responses allow them to combat biological insults, regulate growth, and regulate genes involved in stress; all these responses increase tolerance to antibiotics. The current therapies to treat mycobacterial infections are lengthy and, at times, unsuccessful, partly due to antibiotic tolerance. A …
Contributions Of The Replication Initiator Protein Dnaa To Physiology And Virulence Of The Lyme Disease Spirochete, Andrew Krusenstjerna
Contributions Of The Replication Initiator Protein Dnaa To Physiology And Virulence Of The Lyme Disease Spirochete, Andrew Krusenstjerna
Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics
Borrelia burgdorferi, the etiological agent of Lyme disease, is the most prevalent vector-borne disease in the United States. The spirochetal population is naturally maintained by consistently cycling between Ixodid ticks and small vertebrates. To survive within these diverse niches, B. burgdorferi has evolved a unique physiology and regulatory network to sense and respond to environmental fluxes. Replication is a hallmark of the Lyme spirochete’s enzootic life cycle, specifically at the nymphal tick-to-vertebrate interface. The mechanisms and regulatory schema for the basic cellular processes in B. burgdorferi, or indeed any member of the phylum spirochaetota, are largely unknown. The central hypothesis …
Functional Analyses Of The Dna- And Rna-Binding Protein Spovg In Borrelia Burgdorferi, Christina R. Savage
Functional Analyses Of The Dna- And Rna-Binding Protein Spovg In Borrelia Burgdorferi, Christina R. Savage
Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics
Borrelia burgdorferi, the causative agent of Lyme disease, exists in a defined enzootic cycle involving Ixodes scapularis ticks and various vertebrates. Humans can serve as an accidental host, if a tick colonized with B. burgdorferi happens to feed on a human. B. burgdorferi are also accidental pathogens: they do not make toxins, or destroy host tissue by other mechanisms. They merely transmit between vector and host to survive. In order to do this, they must effectively sense their current environment, and appropriately alter cellular processes. Understanding the regulatory mechanisms of how B. burgdorferi manages to do this has been …
The Role Of Cody In Hydrogen Peroxide Tolerance And Biofilm Formation Of Streptococcus Mutans, Kaitlin M. Rioux, Brandaliz Santiago-Narvaez
The Role Of Cody In Hydrogen Peroxide Tolerance And Biofilm Formation Of Streptococcus Mutans, Kaitlin M. Rioux, Brandaliz Santiago-Narvaez
Honors Program Theses
Streptococcus mutans is the major cariogenic bacterium in the oral cavity. S. mutans causes disease by three main virulence factors: acid production, acid tolerance, and biofilm formation. S. mutans outcompetes various other species in the oral cavity, however it is affected by hydrogen peroxide production by these species. Based on previous findings and this research, hydrogen peroxide is shown to extend the lag phase of S. mutans but does not kill it unless present in extremely high amounts that are generally not produced by commensal species like S. sanguinis and S. gordonii in the oral cavity. CodY is a global …
Insights Into The Reactivation, Regulation And Essentiality Of Oxidative Protein Folding Pathways In Actinobacteria, Belkys Sanchez
Insights Into The Reactivation, Regulation And Essentiality Of Oxidative Protein Folding Pathways In Actinobacteria, Belkys Sanchez
Dissertations and Theses (Open Access)
Accurate disulfide bond formation is important for proper folding, stability and function of exported proteins. The process of disulfide bond formation, termed oxidative protein folding, is catalyzed by thiol-disulfide oxidoreductase enzymes. Oxidative protein folding pathways influence processes essential for bacterial physiology and pathogenicity. In the Gram-positive actinobacterial pathogens Actinomyces oris and Corynebacterium diphtheriae oxidative protein folding is catalyzed by the primary thiol-disulfide oxidoreductase MdbA. MdbA is required for assembly of adhesive pilus, which mediate receptor-dependent bacterial interactions, or coaggregation, in A. oris. In the first part of this dissertation, I identify components of the electron transport chain (ETC) required for …
Insights Into Key Gene Regulatory Networks In Borrelia Burgdorferi, William Kenneth Arnold
Insights Into Key Gene Regulatory Networks In Borrelia Burgdorferi, William Kenneth Arnold
Theses and Dissertations--Microbiology, Immunology, and Molecular Genetics
Gene regulatory networks are composed of interconnected regulatory nodes created by regulatory factors of multiple types. All organisms finely tune gene expression in order to adapt to and survive within their current niche. Obligate parasitic bacteria are under extreme pressure to quickly and appropriately adapt their gene regulatory programs in order to survive within their given host. Borrelia burgdorferi is one such organism and persists in nature by alternating between two hosts; Ixodes spp. ticks and small vertebrate animals. These two hosts represent drastically different environments; requiring a unique gene regulatory program to survive and transmit between them. Microbiologists have …