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Full-Text Articles in Microbial Physiology
Repurposing Cyclin-Dependent Kinase Inhibitors For The Discovery Of Novel Antiplasmodial Compounds, Ritam Bhowmik
Repurposing Cyclin-Dependent Kinase Inhibitors For The Discovery Of Novel Antiplasmodial Compounds, Ritam Bhowmik
Honors Undergraduate Theses
Malaria remains a major global health burden with over 282 million cases annually and rising resistance to artemisinin-based combination therapies. Plasmodium falciparum, the most lethal malaria parasite species in humans, relies on tightly regulated cell cycle progression during replication within red blood cells. Cyclin-dependent kinases (CDKs) are central regulators of eukaryotic cell division and transcription, and several CDK-like enzymes in P. falciparum, including Pfmrk and PfPK6, are essential for parasite growth and structurally distinct from human kinases. This study evaluated whether commercially available human CDK inhibitors (CDKIs) targeting cancer pathways could be repurposed as novel antimalarial compounds. A library of …
Analysis Of The Prevention Of Biocorrosion Caused By Desulfovibrio Alaskensis G20, Michael Boring
Analysis Of The Prevention Of Biocorrosion Caused By Desulfovibrio Alaskensis G20, Michael Boring
Honors Undergraduate Theses
Desulfovibrio alaskensis G20 and other sulfate-reducing bacteria cause significant damage to metal pipelines and other infrastructure through a metabolic pathway that releases toxic hydrogen sulfide into their surroundings. The biocorrosion that results from the release of hydrogen sulfide creates significant economic burden, and can pose health risks for those exposed to this chemical. They are commonly present in the form of biofilms, an extracellular matrix composed of bacterial cells, polysaccharides, proteins, nucleic acids, and other materials. These biofilms are difficult to remove, and they provide protection to the bacteria within from anti-bacterial treatments. Desulfovibrio alaskensis G20 is a strain derived …