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Serum Myostatin And Igf-1 As Biomarkers Of Sarcopenia: A Proof-Of-Concept Design, Ashley Binns Dec 2019

Serum Myostatin And Igf-1 As Biomarkers Of Sarcopenia: A Proof-Of-Concept Design, Ashley Binns

Graduate Theses and Dissertations

The population comprising older adults is growing exponentially, as are healthcare related costs. Nearly $20 billion is annually expensed by older adults for health-related issues affiliated with age-related decline in skeletal muscle mass. Yet, diagnostic criteria are not readily utilized in clinical practice. PURPOSE: Therefore, the purpose of this study was to provide evidence for use of blood biomarkers (myostatin, IGF-1) to predict appendicular skeletal muscle mass (ASM) among middle-aged and older adults. METHODS: A cross-sectional study was conducted among 106 individuals (n = 68 females; n = 38 males) aged ≥ 40 years of age (60.1 ± 11.1 y) …


The Effect Of Dehydration On Metabolism And Energy Substrate Utilization, Zachary Robert Lewis Dec 2018

The Effect Of Dehydration On Metabolism And Energy Substrate Utilization, Zachary Robert Lewis

Graduate Theses and Dissertations

The purpose of this study was to measure hormonal and metabolic markers in humans to see if simulating dehydration would emulate measures that are seen in prediabetic humans. 60 volunteers were divided into equal categories by sex and body mass index of normal or overweight. Participants completed two oral glucose tolerance tests (OGTT) after being intravenously infused with a isotonic or hypertonic saline solution for 120 minutes in a counter balanced order. All trials began with a euhydrated subject with a urine specific gravity (USG)


Dehydration, Muscle Damage, And Exercise In The Heat: Impacts On Renal Stress, Thermoregulation, And Muscular Damage Recovery, Cory L. Butts Aug 2018

Dehydration, Muscle Damage, And Exercise In The Heat: Impacts On Renal Stress, Thermoregulation, And Muscular Damage Recovery, Cory L. Butts

Graduate Theses and Dissertations

Purpose: The purpose was to identify the combined influence of dehydration, muscle damage, and exertional hyperthermia on biological markers of acute kidney injury and renal function. We also investigated the effects of performing muscle damaging exercise during mild hypohydration on muscle damage biomarkers and muscular strength recovery. Methods: Eighteen recreationally-active males (age 24 ± 5 y, body fat 17.3 ± 6.2%) completed a familiarization visit and two experimental trials separated by ≥28 days. The two experimental conditions consisted of either euhydration (EU; maintaining hydration, -1.2 ± 0.8%) or hypohydration (HY; restricting fluid consumption for 24 hours prior to and during …


The Validity Of Urine Color Self-Assessment As An Index Of Hydration In Males, Daniel Layne Nixon Dec 2015

The Validity Of Urine Color Self-Assessment As An Index Of Hydration In Males, Daniel Layne Nixon

Graduate Theses and Dissertations

While water intake is so important, there are few practical hydration assessment techniques for the general population to use on a daily basis. The present study examined the accuracy of self-assessed urine color (Ucol) as a potential hydration assessment tool. Male college aged subjects provided a urine sample into a custom built urinal (n=76; 1.79±0.76 m, 83.9±16.0 kg). The urinal contained a picture of the 1-8 color scale and a light and dark urine color scale. Subjects were asked to give their urine color estimation as a whole number integer and to estimate if their urine was light or dark. …


The Longitudinal Effects Of Beta-Alanine Supplementation On Isometric Strength, Time To Exhaustion, And Lower-Body Isometric Torque In Female Masters Athlete Cyclists, Jordan Mckenzie Glenn Jul 2015

The Longitudinal Effects Of Beta-Alanine Supplementation On Isometric Strength, Time To Exhaustion, And Lower-Body Isometric Torque In Female Masters Athlete Cyclists, Jordan Mckenzie Glenn

Graduate Theses and Dissertations

Within the population of aging individuals exists a subset of competitive seniors or masters athletes (MA). As masters-level competition increases in popularity, MA must find methods to enhance individual athletic performance. Beta-alanine (BA) is an amino acid used to enhance physical capability based on ability increase intramuscular carnosine concentrations. Older adults and females have naturally lower carnosine levels compared to age- and gender-matched counterparts and may experience enhanced benefits from BA supplementation. Purpose: Therefore, the purpose of this investigation was to examine the longitudinal effects of BA supplementation on isometric handgrip strength (HG), time to exhaustion (TTE), total work completed …


The Comparative Effects Of Hot Yoga And Thermoneutral Yoga On Flexibility, Heart Rate, Sweat Rate, And Mood, Hannah Kirkland Campbell Jul 2015

The Comparative Effects Of Hot Yoga And Thermoneutral Yoga On Flexibility, Heart Rate, Sweat Rate, And Mood, Hannah Kirkland Campbell

Graduate Theses and Dissertations

Yoga is an ancient Indian philosophy, described as a therapeutic intervention and health maintenance practice that unites the mind and body to aid healing through the combination of physical postures, breathing techniques, and meditation. There is ample research regarding yoga practiced in an environment that is thermoneutral, or in an environment that does not alter the metabolic heat production or evaporative heat loss of people. However, minimal research exists on the increasingly popular form of yoga known as hot yoga, or yoga practiced in an environment that is often humidified and 95° F or warmer. This exploratory study compared the …


Perceptual Differences In Children Learning To Play Golf With Traditional Or Modified (Scaled) Equipment, Lindsey Dawn Sams May 2015

Perceptual Differences In Children Learning To Play Golf With Traditional Or Modified (Scaled) Equipment, Lindsey Dawn Sams

Graduate Theses and Dissertations

The purpose of the present study was to examine perception differences of competence and enjoyment between learners using modified and traditional equipment, and the potential effects these factors could have on intent for future participation. The participants in this study were 123 children (65 girls, 58 boys) aged 7 to 17 years. Through a convenience sampling method, data was obtained through surveys measuring golf participation and self-perceptions concerning perceived competence, enjoyment and intention to continue participation. To avoid an age confound, the dataset was limited to 2nd through 5th grade children (24 traditional/ 75 modified) for secondary analyses (MANOVA and …


The Effect Of Physical Activity Levels On Hydration Markers In Non-Athletic Free-Living Individuals, Mikell Lucas Hammer May 2015

The Effect Of Physical Activity Levels On Hydration Markers In Non-Athletic Free-Living Individuals, Mikell Lucas Hammer

Graduate Theses and Dissertations

Higher levels of physical activity requires increased fluid intake due to increased water losses via sweating. PURPOSE: To determine the effect of physical activity on hydration status and water intake. METHODS: This study involved 8 visits to the Human Performance Laboratory over 22 days. Body weight and urine measurements were taken every visit. Physical activity was assessed by the International Physical Activity Questionnaire (IPAQ), water intake by the Water Frequency Questionnaire (WFQ), and hydration status by urine osmolality (UOsm), urine specific gravity (USG), and urine color (UC). From the IPAQ subjects were classified as low, moderate and high physical activity …


The Effects Of Apoe Knock Out On Skeletal Muscle Regeneration: A Look Into Markers Of Protein Synthesis And Satellite Cell Function, Joshua Eden Ragland May 2014

The Effects Of Apoe Knock Out On Skeletal Muscle Regeneration: A Look Into Markers Of Protein Synthesis And Satellite Cell Function, Joshua Eden Ragland

Graduate Theses and Dissertations

ApoE helps regulate serum cholesterol levels by adding in transport of cholesterol into the cells, as well as, to the liver. ApoE knockout mice (ApoE KO) present a model that demonstrates the effects of hypercholesterolemia. Damage to muscle stimulates a complex regenerative response. The effects of high cholesterol on this regenerative response are not known. PURPOSE: To determine if skeletal muscle regeneration is altered in apoE KO mice by measuring protein synthesis regulator IGF-1, Akt, mTOR, and p70S6K, cell cycle regulator cyclin D1, and myogenic regulatory factors myoD and myogenin. METHODS: Female C57/BL6 (WT) and apoE KO were assigned to …


An Analysis Of Firearms Training Performance Among Active Law Enforcement Officers, John Thomasson May 2013

An Analysis Of Firearms Training Performance Among Active Law Enforcement Officers, John Thomasson

Graduate Theses and Dissertations

Firearms proficiency is an implicit expectation, held by the public of police officers, due to presumption that the required firearm training is an adequate preparation for a deadly force encounter. However, anecdotal evidence and available data on police shootings suggest that conventional, unrealistic training methods are wholly inadequate. To present stress into firearms training, some departments have opted for exercises such as physical exertion and shoot-house training as a substitute for realistic simulation of force-on-force confrontations.

To determine whether such exercises are comparable, an observation of performance and heart rate levels was conducted on a group of eight police officers, …